Resources & Opportunities
Assistant Professor in Mechanical Engineering- TISSUE ENGINEERING (F23)The Department of Mechanical Engineering (ME) invites applications for a tenure-track faculty position, starting August 28, 2023. Although candidates at the Assistant Professor rank are preferred, candidates with exceptional experience and qualifications may be considered for the rank of Associate Professor.Visit
Assistant Professor in Mechanical Engineering- BIOPROCESSING (F23)The Department of Mechanical Engineering (ME) invites applications for a tenure-track faculty position, starting August 28, 2023. Although candidates at the Assistant Professor rank are preferred, candidates with exceptional experience and qualifications may be considered for the rank of Associate Professor.Visit
Michigan – Pittsburgh – Wyss Regenerative Medicine Resource Center Interdisciplinary Translational Project (ITP) Program-Pre-Proposals due November 1, 2022The Michigan-Pittsburgh-Wyss Regenerative Medicine (MPWRM) Resource Center is one of the two national Resource Centers established by the National Institute of Dental and Craniofacial Research (NIDCR)’s Dental Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC) initiative. With the overarching goal of developing clinical trial-ready tissue engineering/ regenerative medicine products and protocols, the DOCTRC initiative is providing funding and resources through the Interdisciplinary Translational Project (ITP) program administered by the two national Resource Centers.Visit
Tenure Track Research Faculty Position-Department of Orthopaedic SurgeryThe Department of Orthopaedic Surgery at the University of Michigan Medical School is recruiting for a tenure-track faculty member at the level of Assistant Professor as part of the campus-wide Biosciences Initiative focused on Programmable Biomaterials for Regenerative Medicine. A candidate with experience and interest in biomaterial-based regenerative strategies and a focus on musculoskeletal research, particularly joint health and disease is desired. Further, the candidate should have a proven track record in publishing and acquiring extramural funding.Visit
Scientist - Tissue SystemsUnited Therapeutics Corporation focuses on the strength of a balanced, value-creating biotechnology model. We are confident in our future thanks to our fundamental attributes, namely our commitment to quality and innovation, the power of our brands, our entrepreneurial culture and our bioinformatics leadership. We also believe that our determination to be responsible citizens — having a positive impact on patients, the environment and society — will sustain our success in the long term.Visit
UC Irvine Full-time Position Lab Assistant IIThe job will be working on a Tran-1 grant, Stem Cell transplantation for Cervical Spinal cord injury. The duties include animal surgery, animal care, behavior tasks, behavior analysis, histology, stereology, and may include cell culture, western blots, other assays. If you apply to this position, please send Cait (email@example.com) an email letting her know of your submitted application.Visit
Call for Applications: BI Innovation Fellowship-Applications due October 15, 2021The Biointerfaces Institute is seeking applications for an inaugural cohort of BI Innovation Fellows. The Innovation Fellowship is a full-time position for up to two years at a competitive $60,000 salary with full benefits. The program offers a unique opportunity for Fellows to be embedded within the BI research and translational ecosystem to explore research commercialization.Visit
Activate Cohort 2022 RecruitmentActivate empowers scientists to reinvent the world by bringing their research to market. The two-year Activate Fellowship provides the most promising science entrepreneurs the funding, technical support, networking, community, and time they need at the outset of their entrepreneurial journey. And Activate does not take a stake in their startups.Visit
OHSU Research Associate- Biomaterials and Biomechanics DepartmentThe Biomaterials and Biomechanics Department is seeking an enthusiastic research associate to begin immediately. The successful candidate will be joining a dynamic multi-disciplinary group, including material scientists, polymer chemists, mechanical engineers and microbiologists. This position requires research performance consistent with the goals of the principal investigator, Carmem Pfeifer PhD. The lab is very active, with opportunities to publish papers, submit grant proposals, present at technical meetings, and work with partners in industry and university / government. Many of our lab members have been listed as co-authors in patents, and have later found senior positions in industry and academia.Visit
Johns Hopkins University-Postdoctoral Researcher for National Institute of Standards and Technology (NIST)In vitro and acellular assays can play an important role in determining the biocompatibility of biomedical products such as dental materials. These assays used in conjunction with a decision framework such as Adverse Outcome Pathways (AOPs) can provide biologically relevant information for predicting biocompatibility effects in physiological systems. To ensure these assays perform as expected and provide high-quality test results, evaluation of the precision and robustness of these assay measurements is required. This postdoctoral opportunity will feature comprehensive examination of in vitro or other assays relevant to the biocompatibility of dental materials to improve the repeatability, comparability and interlaboratory agreement of the assay results. This could entail comparison of assay technologies, using cause-and-effect analysis to understand sources of variability in the assay, designing new assay plate layouts that include key process control measurements, identification and selection of reference materials and utilizing appropriate statistical analyses to understand the assay results and their uncertainties. This program will allow the selected candidate to lead assay development activities with a focus on improving the comparability and reproducibility of biocompatibility assay results within and between laboratories.Visit
RNA Faculty Positions- Applications due September 15, 2021The Center for RNA Biomedicine at the University of Michigan invites applications for a tenure-track position in RNA Biomedicine (including In vivo analysis of long non-coding RNA function, RNA drug targeting or medicine, RNA protein interaction profiling, RNA structural in vivo profiling, Structural biology of RNA nanomachines) with an anticipated start date of September 1, 2022 or January 1, 2023. The position is expected to be filled at the assistant professor level. The faculty position will be tenure track with a university year appointment.Visit
U-M Concussion Center faculty position opportunities-beginning August 15, 2021 until filledThree tenure track faculty positions available, including 1 senior concussion faculty member (currently associate or full professor), and 2 junior concussion faculty members (currently PhD student, post-doc, medical resident/fellow, or assistant professor)Visit
Assistant/Associate or Professor, Tenure-Track Faculty Position(s), College(s) of Engineering, Pharmacy, and Medicine, University of Michigan, Ann Arbor-October 1, 2021The University of Michigan Biosciences Initiative and collaborating units recently awarded a combined intramural grant of $15M to the BioInnovations in Brain Cancer (BIBC) Program. This multi-disciplinary group is rooted in collaborations between brain cancer experts, clinicians, and technologists to drive innovation and translation that will deliver technological breakthroughs that impact brain cancer patients’ lives. The BIBC is currently soliciting applications for tenure track faculty positions at any level.Visit
Activate Science 2023 Fellowship- Deadline October 31, 2022Activate helps scientists develop as leaders, mature their ideas, and learn what it takes to build a viable, scalable business. We’ve learned a lot from helping dozens of scientists become entrepreneurs. And we want to share it with any scientist who dreams of bigger things.Visit
FFMI Innovation Studio- 3rd Tuesday of Every MonthThe new FFMI Innovation Studio provides life science innovators of all levels with individual consulting to address project needs, challenges, or questions. Participants will get the chance to engage and consult with experts from Fast Forward Medical Innovation and the broader University of Michigan entrepreneurship network, including the Office of Tech Transfer, the Ross School of Business Zell Lurie Institute for Entrepreneurial Studies, and the College of Engineering’s Center for Entrepreneurship.Visit
U-M Regenerative Medicine Translational Research Post-Doctoral Fellowship ProgramThe program provides a structured training opportunity to prepare post-doctoral fellows for a career as an independent entrepreneurial research investigator or for a translationally-oriented career in non-academic sectors. It is designed to enable an existing post-doctoral fellow at U-M to spend 50% effort continuing to pursue their current independent laboratory research, and the other 50% engaging in translational research/ commercialization training, with the costs to be split between the mentoring faculty/ principal investigator and the program. The fellow will have an opportunity to explore the commercial potential of a project on which he/she is working, or another one from your laboratory.Visit
MICHR Summer 2022MICHR offers a summer research program for pre-doctoral students in health-related professional degree programs at U-M as well as at other U.S. institutions studying in these fields. The three-month full-time program is designed to introduce students to research early in their courses of study, and provides hands-on research experiences in health disparities, precision health, regulatory science, or clinical research. Students will learn the fundamentals of research methods through individualized and team-based learning experiences. The program may serve as an internship for students who need to fulfill such requirements.Visit
FFMI fastPACEFFMI fastPACE is a 4-week biomedical innovation and commercialization course designed for life science innovators with an early-stage project. The fastPACE Course helps participants prepare a successful business case for funding and development partnerships.Visit
UROP Applications-July 31UROP is now accepting research project submissions for the next academic year. Mentoring an undergraduate in research can help you shape the future of your discipline and attract new researchers to your field. UROP is here to help you do that in a structured way.Visit
Precision Health Graduate Certificate Program- Application due: August 1, 2021The new U-M Precision Health Graduate Certificate Program has arrived to educate current and future practitioners and researchers in this emerging field so they can become better equipped to customize patient care. Only 12 credits of graduate coursework required Great opportunity for graduate students to design their own plan Network with other precision health students and faculty at seminars and professional development workshops Mentoring with faculty The certificate is open to all graduate students enrolled at U-M. Application deadline is August 1.Visit
Prepare to write successful new ARPA-H grants by Drs. Christian Macedonia, Indika Rajapakse, and Rachel WallaceTo address the concerns from bipartisan Congressional pressure to Science agencies, which include potential loss of American leadership in critical areas and increasingly limited patience for the low translation of basic research, Congress and Biden administration have established an independent new science agency ARPA-H: The Advanced Research Projects Agency for Health (https://arpa-h.gov/). The mission of ARPA-H is “to benefit the health of all Americans by catalyzing health breakthroughs that cannot readily be accomplished through traditional research (e.g. NIH) or commercial activity (e.g. Pharmaceutical industry).” Attached please find a summary of ARPA-H from UM OVPR and ARPA-H FAQ.Visit
FFMI Innovation Studio- every third Tuesday of each monthParticipants will get the chance to engage and consult with experts from Fast Forward Medical Innovation and the broader University of Michigan entrepreneurship network, including the Office of Tech Transfer, the Ross School of Business Zell Lurie Institute for Entrepreneurial Studies, and the College of Engineering’s Center for Entrepreneurship. All are available to advise on innovation concepts, opportunities for commercialization education, funding resources, or any other innovation concerns that faculty, staff, or trainees may have.Visit
- FFMI fastPACE (a 4-week biomedical innovation and commercialization course designed for the busy medical academician with an early stage project)
- Education and Training programs available from MICHR
- SBIR/STTR Training from BBC Entrepreneurial Training & Consulting
- Tissue Engineering and Regeneration Grant (training grant) Tissue Engineering and Regeneration (TEAM) is an interdisciplinary research-intensive training program for individuals who wish to pursue careers in the oral sciences with a focus in the area of restoration of oral-craniofacial tissues.
- Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center
- California Institute of Regenerative Medicine
- McGowan Institute for Regenerative Medicine
- Wake Forest Institute for Regenerative Medicine
- Regenerative Medicine Foundation
- Tissue Engineering and Regenerative Medicine International Society
- American Academy and Board of Regenerative Medicine
- The Transplantation Society
- International Society for Stem Cell Research
- Biomedical Engineering Society
- Society for Biomaterials
- Materials Research Society
- Osteology Foundation
- Advanced Regenerative Manufacturing Institute
- Navigating the Manufacturing Process and Ensuring the Quality of Regenerative Medicine Therapies – Proceedings of a Workshop
- The Regenerative Medicine Standards Landscape: This report provides a snapshot of the current landscape for regenerative medicine standards. It outlines existing and in-development standards, providing a reference that individual organizations can use to identify available standards to improve their operations.
- Needed Standards in Regenerative Medicine: Community Perspectives: Needed Standards in Regenerative Medicine report. The objective of the report is to outline standards needs identified by the community that could have the greatest benefit to the field and improve the safety and quality of regenerative medicine products.
Good Laboratory Practice (GLP)
- 21 CFR Part 58: Good Laboratory Practice for Nonclinical Laboratory Studies
- FDA Guidance: Questions and Answers on Good Laboratory Practice (March 1998)
- FDA Compliance Program Guidance Manual 7348.808 Good Laboratory Practice (May 2018)
- 21 CFR Part 812: Investigational Device Exemptions
- 21 CFR Part 814: Premarket Approval of Medical Device
- 21 CFR Part 820: Quality System Regulation
- FDA Guidance: Use of International Standard ISO 10993-1, “Biological Evaluation of Medical Devices – Part: Evaluation and Testing within a Risk Management Process” (June 2016)
- FDA Guidance: General Considerations for Animal Studies for Medical Devices (Oct 2015)
- FDA Guidance: The 510(k) Program: Evaluating Substantial Equivalence in Premarket Notifications [510 (k)] (Jul 2014)
- FDA Guidance: Evaluation of Devices Used with Regenerative Medicine Advanced Therapies (Feb 2019)
Meeting with the FDA
- FDA Compliance Program Guidance Manual 7348.808 Good Laboratory Practice
- FDA Guidance: Requests for Feedback and Meetings for Medical Device Submissions: The Q-Submission Program (May 2019)
Cellular and Gene Therapy products
- FDA Guidance: Preclinical Assessment of Investigational Cellular and Gene Therapy Products (Nov 2013)
- FDA Guidance: Current Good Tissue Practice (CGTP) and Additional Requirements for Manufacturers of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) (Dec 2011)
- FDA Guidance: Regulatory Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous Use (Dec 20, 2017)
Other FDA Guidance
The scientific goals of this SRI are to catalyze regenerative medicine (RM) at UM through a materials-centric approach by: identifying patterns and signatures in tissues in spatially and temporally; incorporating this information into materials design; and engineering tissues based on materials with sensing, diagnostic and therapeutic abilities. Equally important is the creation of an enabling environment for the RM community at UM. We’d like to take this opportunity to communicate some of the enabling activities we have implemented and benefits of being involved in our BSI program. These activities sync with our philosophy that teams out-compete individuals and are geared toward integrating RM expertise across campus to better engage people and create an environment to foster new ideas and make “big” things happen.
We had a successful initial Grand Challenge earlier this year with the theme of how to regenerate tissues/organs to optimally integrate with the host. We brought together clinicians, scientists, and engineers to explore new ideas and catalyze new collaborations to address key barriers to the translation of RM technologies. Following talks defining clinical problems and emerging technologies as potential solutions, breakouts led to the definition of key barriers, which informed RFA centered around incorporating programmable materials to control the key biological elements inhibiting clinical success of tissue engineered medical products (TEMPs). We funded 3 proposals/new partnerships in the areas of programmable materials for monitoring inflammation and regeneration (Aaron Morris, BME, Katherine Gallagher, Surgery & Peter Tessier, Pharmacy); host integration of cell-dense, microvascularized grafts using in situ programmable hydrogel composites (Brendon Baker, BME & Mario Fabiilli, Radiology); and engineered IL-2 muteins for immunotherapy against inflammation and autoimmune diseases (James Moon, Pharmacy & Isabelle Lombaert, Dentistry). Plans are underway in Spring 2023, tentatively centered around aspects of translation unique to regenerative medicine.
Drs. Brendon Baker and Ariella Shikanov launched two groups that meet monthly to brainstorm: a PI group and a student group, Biomaterials in Regenerative Medicine (BIRM). Both groups bring researchers with shared interests together on a regular basis. PI meetings facilitate collaborations and focus on formulating and critiquing specific aims to improve grant success. The student-focused meetings offer opportunities for trainees to present their research and stay current with the literature 2nd Wednesday of the month. Both meetings are open to all – please contact Brendon, Ariella or Cait for more information.
Our SRI helped support UM’s membership in the Advanced Regenerative Manufacturing Institute (ARMI), which enables anyone at UM to access ARMI’s services, including funding opportunities exclusive to members; access to shared facilities, equipment and discounts on materials; BioFab and regulatory consulting and access to a regulatory library. Several PIs at UM, including Lisa Larkin, Ariella Shikanov and Steve Feinberg, have taken advantage of ARMI’s services as their technologies get closer to FDA submissions.
In addition to these ongoing activities, we surveyed the RM community at UM for additional activities of interest. Responses were bracketed into 5 areas: 1) funding opportunities, 2) translational guidance, 3) team building; 4) networking; 5) specific scientific expertise needed. We are prioritizing activities to be responsive to these needs of the community, but here are a few ideas. The monthly meetings have created an ecosystem for collaboration. To date we have focused on informal guidance in specific aims, but are happy to expand to more formal grant reviews. The interactions also position us to form research interest groups and position UM to be proactively responsive to RFAs.
Leveraging the structure and expertise developed as part of the Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center, we are in position to offer translational RM guidance to UM investigators as related to the development of a technology via the Translational Research Consult Program. Example topics include: how might the envisioned product be classified by the FDA, what elements affect this classification, and what are the pathways associated with that classification? What are some Good Laboratory Practice (GLP) protocol requirements that might be relevant to the envisioned product? What factors should be considered as first target indication is defined?
We will re-launch a RM translational fellowship in 2023. This fellowship will provide a structured program to prepare trainees for a career as an entrepreneurial investigator or for a translationally oriented career in non-academic sectors. Trainees will split effort pursuing independent laboratory research and engaging in translational research/commercialization training.
Please also visit our website, which we hope to evolve into a one-stop gateway to promote and enhance research and educational activities in RM at UM and serve as a resource for UM researchers. The website is updated weekly with events and funding opportunities.