Stem Cells/Organoids

From understanding the fundamental biology of stem cells to the development of structually organized functional organoids, researchers seek to reveal the mechanism and pathophysiology of disease, enabling exploitation of such knowledge to promote tissue regeneration.

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Aguilar CA et al. Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma. Stem Cell Reports. 2016.
Aguilar CA et al. Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury. Cell Death Discov. 2018.
Aguilar CA et al. Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. J Immunology. 2020.
Aguilar CA et al. Dissecting murine muscle stem cell aging through integrative genomic analysis. Cell Rep. 2020.
Aguilar CA et al. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight. 2020.
Aguilar CA et al. Engineered Tools to Study Intercellular Communication. Adv Sci (Weinh). 2021.
Aguilar CA et al. Metabolipidomic profiling reveals an age-related deficiency of skeletal muscle pro-resolving mediators that contributes to maladaptive tissue remodeling. Aging Cell. 2021.
Aguilar CA et al. Sestrins regulate muscle stem cell metabolic homeostasis. Stem Cell Reports. 2021.
Aguilar et al. Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Commun Biol. 2020.
Aguilar et al. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci U S A. 2022.
Aguilar et al. Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma. Ann Surg. 2023.
Aguilar et al. Three-dimensional chromatin re-organization during muscle stem cell aging. Aging Cell. 2023.
Aguilar et al. Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss. JCI Insight. 2023.
Aguilar et al. Tracking of Nascent Matrix Deposition during Muscle Stem Cell Activation across Lifespan Using Engineered Hydrogels. Adv Biol (Weinh). 2024.
Allen BL et al. Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 2014.
Allen BL et al. Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Biol Chem. 2015.
Allen BL et al. Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif. J Biol Chem. 2017.
Allen BL et al. Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib. Proc Natl Acad Sci U S A. 2017.
Allen BL et al. The Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. Development. 2020.
Allen BL et al. Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer. Clin Cancer Res. 2021.
Allen et al. Unique lingual expression of the Hedgehog pathway antagonist Hedgehog-interacting protein in filiform papillae during homeostasis and ectopic expression in fungiform papillae during Hedgehog signaling inhibition. Dev Dyn. 2022.
Allen et al. C-X-C motif chemokine ligand 1 induced by Hedgehog signaling promotes mouse extrahepatic bile duct repair after acute injury. Hepatology. 2022.
Allen et al. Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer. PLoS Genet. 2022.
Allen et al. CDON contributes to Hedgehog-dependent patterning and growth of the developing limb. Dev Biol. 2023.
Allen et al. Developing Future Biologists: developmental biology for undergraduates from underserved communities. Development. 2023.
Allen et al. Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis. PLoS One. 2024.
Allen et al. Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth. Cancer Discov. 2024.
Baker BM et al. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017.
Baker BM et al. Cell force-mediated matrix reorganization underlies multicellular network assembly. Sci Rep. 2019.
Baker BM et al. Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration. Nat Commun. 2019.
Baker BM et al. Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Lab Chip. 2020.
Baker BM et al. Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis. Sci Adv. 2020.
Baker BM et al. Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices. Biomater Sci. 2021.
Baker BM et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.
Baker BM et al. Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform. Lab Chip. 2021.
Baker BM et al. New directions and dimensions for bioengineered models of fibrosis. Nat Review Mater. 2021.
Baker BM et al. Quantification and immunoprofiling of bladder cancer cell-derived extracellular vesicles with microfluidic chemiluminescent ELISA. Biosens Bioelectron: X. 2021.
Baker et al. Physical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels. Adv Funct Mater. 2022.
Baker et al. Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation. Acta Biomater. 2021.
Baker et al. Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology. Adv Mater. 2021.
Baker et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Baker et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.
Baker et al. Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D. Adv Sci (weinh). 2022.
Baker et al. The living interface between synthetic biology and biomaterial design. Nat Mater. 2022.
Baker et al. Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel. Acta Biomater. 2023.
Baker et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022.
Baker et al. A data-driven computational model for engineered cardiac microtissues. Acta Biomater. 2023.
Baker et al. Mechanical Intercellular Communication via Matrix-Borne Cell Force Transmission During Vascular Network Formation. Adv Sci (Weinh). 2024.
Baker et al. Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease. iScience. 2023.
Baker et al. Sulfide oxidation promotes hypoxic angiogenesis and neovascularization. Nat Chem Biol. 2024.
Baker et al. MicroBundleCompute: Automated segmentation, tracking, and analysis of subdomain deformation in cardiac microbundles. PLoS One. 2024.
Baker et al. A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses. Adv Funct Mater. 2024.
Baker et al. Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites. Adv Healthc Mater. 2024.
Bottino et al. Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction. Dent Mater. 2022.
Bottino et al. Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies. Clin Oral Investig. 2021.
Bottino et al. A Highly Ordered, Nanostructured Fluorinated CaP-Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration. Adv Healthc Mater. 2021.
Bottino et al. Dental education 2026: A scenario exploration. J Dent Educ. 2022.
Bottino et al. Scenario IV: Under-resourced but resilient and transformative. J Dent Educ. 2022.
Bottino et al. Do resin cement viscosity and ceramic surface etching influence the fatigue performance of bonded lithium disilicate glass-ceramic crowns?. Dent Mater. 2022.
Bottino et al. Unveiling the potential of melt electrowriting in regenerative dental medicine. Acta Biomater. 2023.
Bottino et al. Novel cinnamon-laden nanofibers as a potential antifungal coating for poly(methyl methacrylate) denture base materials. Clin Oral Investig. 2022.
Bottino et al. Engineering of Injectable Antibiotic-Laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation. Int J Mol Sci. 2022.
Bottino et al. Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review. Int Endod J. 2022.
Bottino et al. Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues. Bioact Mater. 2023.
Bottino et al. Natural monoterpenes-laden electrospun fibrous scaffolds for endodontic infection eradication. Odontology. 2023.
Bottino et al. Photocrosslinkable methacrylated gelatin hydrogel as a cell-friendly injectable delivery system for chlorhexidine in regenerative endodontics. Dent Mater. 2022.
Bottino et al. Thickness and internal adjustment of monolithic resin composite milled crowns: Effect on the load-bearing capacity under fatigue. J Mech Behav Biomed Mater. 2022.
Bottino et al. Advanced biomaterials for periodontal tissue regeneration. Genesis. 2022.
Bottino et al. Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration. Dent Mater. 2022.
Bottino et al. Development of functional fillers as a self-healing system for dental resin composite. J Dent. 2022.
Bottino et al. Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interface. ACS Appl Mater Interfaces. 2023.
Bottino et al. Next-generation biomaterials for dental pulp tissue immunomodulation. Dent Mater. 2023.
Bottino et al. Synthesis and characterization of calcium-releasing elastomeric resin-based endodontic sealers. Clin Oral Investig. 2023.
Bottino et al. Multifunctional and biodegradable methacrylated gelatin/Aloe vera nanofibers for endodontic disinfection and immunomodulation. Biomater Adv. 2023.
Bottino et al. Effect of desensitizing agents on the resin bond strength to sound dentin. Odontology. 2024.
Bottino et al. GelMA/TCP nanocomposite scaffold for vital pulp therapy. Acta Biomater. 2024.
Bottino et al. Citric Acid Conditioning as an Alternative to EDTA for Growth Factors Release and Stem Cell Response in Regenerative Endodontics: A Systematic Review of In Vitro Studies. J Endod. 2024.
Bottino et al. The rhythms of histones in regeneration: The epigenetic modifications determined by clock genes. Exp Dermatol. 2024.
Bottino et al. Recent advances in additive manufacturing of patient-specific devices for dental and maxillofacial rehabilitation. Dent Mater. 2024.
Bottino et al. Injectable Tissue-Specific Hydrogel System for Pulp–Dentin Regeneration. J Dent Res. 2024.
Bottino et al. Functionalization of PCL-Based Fiber Scaffolds with Different Sources of Calcium and Phosphate and Odontogenic Potential on Human Dental Pulp Cells. J Funct Biomater. 2024.
Bottino et al. Strontium-Doped Bioglass-Laden Gelatin Methacryloyl Hydrogels for Vital Pulp Therapy. J Funct Biomater. 2024.
Bottino et al. Biodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering. J Biomed Mater Res B Appl Biomater. 2024.
Bottino et al. Guidance on the assessment of biocompatibility of biomaterials: Fundamentals and testing considerations. Dent Mater. 2024.
Bottino et al. Sol-gel-derived calcium silicate cement incorporating collagen and mesoporous bioglass nanoparticles for dental pulp therapy. Dent Mater. 2024.
Bottino et al. Amino Acid-Based Poly(ester urea) Biodegradable Membrane for Guided Bone Regeneration. ACS Appl Mater Interfaces. 2024.
Bottino et al. Adhesion to a new CAD/CAM resin composite: Effects of the machining roughness simulation, surface treatments, and long-term aging. Int J Adhes Adhes. 2022.
Bottino et al. Effect of Co, Cu, and Zn ions on the bioactivity and antibacterial properties of a borate bioactive glass. J Non-Cryst Solids. 2023.
Bottino MC et al. A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics. J Biomed Mater Res B Appl Biomater. 2019.
Bottino MC et al. Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration. Acta Biomater. 2020.
Bottino MC et al. Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection Ablation. Biomacromolecules. 2020.
Bottino MC et al. Development and properties of endodontic resin sealers with natural oils. J Dent. 2021.
Bottino MC et al. Metformin-loaded nanospheres-laden photocrosslinkable gelatin hydrogel for bone tissue engineering. J Mech Behav Biomed Mater. 2021.
Bottino MC et al. Alumina particle air-abrasion and aging effects: Fatigue behavior of CAD/CAM resin composite crowns and flexural strength evaluations. J Mech Behav Biomed Mater. 2021.
Buchman et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Buchman et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Buchman et al. Institutional trends in opioid prescribing and utilization after primary cleft lip and palate repair. Plast Reconstr Surg. 2022.
Buchman et al. Reply: Management of Calcified Cephalohematoma of Infancy: The University of Michigan 25-Year Experience. Plast Reconstr Surg. 2022.
Buchman et al. Surgical Timing and Neurocognitive Development among Patients with Craniosynostosis: Analysis of Confounders. Plast Reconstr Surg. 2023.
Buchman et al. Managing the Soft-Tissue Envelope in Facial Feminization Surgery: Filling and Tightening Surgical Approaches. Plast Reconstr Surg. 2023.
Buchman et al. Longitudinal Assessment of Neurodevelopment in Patients With Nonsyndromic Single-Suture Craniosynostosis: A Retrospective Review of 66 Patients. J Craniofac Surg. 2023.
Buchman et al. Adipose-Derived Stem Cells Enhance Graft Incorporation and Mineralization in a Murine Model of Irradiated Mandibular Nonvascularized Bone Grafting. Ann Plast Surg. 2023.
Buchman et al. Reasons for Removal of Rigid Internal Fixation Devices in Craniofacial Surgery: A 20-year Update. J Craniofac Surg. 2024.
Buchman et al. H vessel formation as a marker for enhanced bone healing in irradiated distraction osteogenesis. Semin Plast Surg. 2024.
Buchman et al. Low Prevalence of Clinically Significant Hyponatremia following Cranial Vault Reconstruction for Single-Suture Craniosynostosis. Plast Reconstr Surg. 2024.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Camper et al. Comprehensive Identification of Pathogenic Gene Variants in Patients With Neuroendocrine Disorders. J Clin Endocrinol Metab. 2021.
Camper et al. The phenotypic spectrum associated with OTX2 mutations in humans. Eur J Endocrinol. 2021.
Camper et al. Novel mechanism of pituitary hormone deficiency: genetic variants shift splicing to produce a dominant negative transcription factor isoform. Eur J Endocrinol. 2021.
Camper et al. Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. Hum Mol Genet. 2023.
Camper et al. Novel genes and variants associated with congenital pituitary hormone deficiency in the era of next-generation sequencing. Front Endocrinol (Lausanne). 2022.
Camper et al. Disruption of RNA Splicing Is an Important Contributor to Congenital Hypopituitarism and Other Human Genetic Diseases. Endocrinology. 2023.
Camper et al. Pituitary stem cells: past, present and future perspectives. Nat Rev Endocrinol. 2024.
Camper SA et al. Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era. Endocr Rev. 2016.
Camper SA et al. Next generation sequencing panel based on single molecule molecular inversion probes for detecting genetic variants in children with hypopituitarism. Mol Genet Genomic Med. 2018.
Camper SA et al. PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression. Endocrinology. 2020.
Camper SA et al. Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease. Hum Mol Genet. 2020.
Camper SA et al. Rathke’s cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors. J Clin Invest. 2020.
Camper SA et al. Pituitary Tumors and Immortalized Cell Lines Generated by Cre-Inducible Expression of SV40 T Antigen. Endocrinology. 2021.
Camper SA et al. High-throughput splicing assays identify missense and silent splice-disruptive POU1F1 variants underlying pituitary hormone deficiency. Am J Hum Genet. 2021.
Chandrasekaran et al. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020.
Chandrasekaran et al. The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics. J Clin Invest. 2021.
Chandrasekaran et al. Metabolic remodelling during early mouse embryo development. Nat Metab. 2021.
Chandrasekaran et al. Metabolic signatures of regulation by phosphorylation and acetylation. iScience. 2022.
Chandrasekaran et al. Machine learning to design antimicrobial combination therapies: Promises and pitfalls. Drug Discov Today. 2022.
Chandrasekaran et al. TaxiBGC: a Taxonomy-Guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters and Secondary Metabolite Production Potential in Metagenomes. mSystems. 2022.
Chandrasekaran et al. Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance. iScience. 2023.
Chandrasekaran et al. Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis. iScience. 2024.
Chandrasekaran S et al. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016.
Chandrasekaran S et al. Comprehensive mapping of pluripotent stem cell metabolism using dynamic genome-scale network modeling. Cell Rep. 2017.
Chandrasekaran S et al. Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors. Genome Biol. 2019.
Chandrasekaran S et al. Dynamic Network Modeling of Stem Cell Metabolism, Methods in Molecular Biology: Computational Stem Cell Biology. Methods Mol Biol. 2019.
Chandrasekaran S et al. Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling. Bioessays. 2020.
Chandrasekaran S et al. Next-generation genome-scale metabolic modeling through integration of regulatory mechanisms. Metabolites. 2021.
Chandrasekran et al. Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer. Clin Exp Metastasis. 2022.
Chen et al. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovasc Drugs Ther. 2021.
Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.
Chen et al. Impact of donor blood type on outcomes after prolonged allograft ischemic times. J Thorac Cardiovasc Surg. 2022.
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen et al. Risk factors for heart transplant survival with greater than 5 h of donor heart ischemic time. J Card Surg. 2021.
Chen et al. Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31/FIH1/HIF-1α pathway. J Mol Cell Cardiol. 2022.
Chen et al. RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II. Pharmacol Res. 2022.
Chen et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. Redox Biol. 2022.
Chen et al. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. J Clin Invest. 2022.
Chen et al. Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis. Cells. 2022.
Chen et al. Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Adv Sci (Weinh). 2023.
Chen et al. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates. Cell Metab. 2023.
Chen et al. PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm. JCI Insight. 2023.
Chen et al. Circular RNA as Therapeutic Targets in Atherosclerosis: Are We Running in Circles?. J Clin Med. 2023.
Chen et al. SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies. Cells. 2024.
Chen et al. Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects. Sci Transl Med. 2024.
Chen et al. Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis. Nat Metab. 2024.
Chen YE et al. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration. Biomaterials. 2015.
Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.
Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.
Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.
Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.
Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Chen YE et al. Translating Cardiovascular Genomics to Clinical Practice. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Improving the genome assembly of rabbits with long-read sequencing. Genomics. 2021.
Chen YE et al. Biomimetic tubular scaffold with heparin conjugation for rapid degradation in in situ regeneration of a small diameter neoartery. Biomaterials. 2021.
Chen YE et al. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021.
Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Cohen et al. A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro. Surgery. 2021.
Cohen et al. Early biochemical response to parathyroidectomy for primary hyperparathyroidism and its predictive value for recurrent hypercalcemia and recurrent primary hyperparathyroidism. Surgery. 2021.
Cohen et al. Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics. Ann Surg. 2021.
Cohen et al. LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. Nat Cell Biol. 2021.
Cohen et al. Identification of novel lipid metabolic biomarkers associated with poor adrenocortical carcinoma prognosis using integrated bioinformatics. Surgery. 2022.
Cohen et al. Re-evaluation of combinational efficacy and synergy of the italian protocol in vitro: Are we truly optimizing benefit or permitting unwanted toxicity?. Biomedicines. 2021.
Coleman et al. Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies. Curr Rheumatol Rep. 2022.
Coleman et al. Cartilage thickness mismatches in patellar osteochondral allograft transplants affect local cartilage stresses. J Orthop Res. 2023.
Coleman et al. Osteoporosis GWAS-implicated DNM3 locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels. JBMR Plus. 2024.
Dressler et al. Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021.
Dressler et al. Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation. Cell Chem Biol. 2022.
Dressler et al. Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease. Kidney Int. 2024.
Dressler et al. Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury. Am J Physiol Renal Physiol. 2024.
Duncan et al. The nematode C. elegans senses airborne sound. Neuron. 2021.
Duncan et al. Measurements From Ears With Endolymphatic Hydrops and 2-Hydroxypropyl-Beta-Cyclodextrin Provide Evidence That Loudness Recruitment Can Have a Cochlear Origin. Front Surg. 2021.
Duncan et al. Mapping the developmental potential of mouse inner ear organoids at single-cell resolution. iScience. 2024.
Duncan RK et al. The intrinsic electrophysiological properties of neurons derived from mouse embryonic stem cells overexpressing neurogenin-1. Am J Physiol Cell Physiol. 2010.
Duncan RK et al. Combining topographical and genetic cues to promote neuronal fate specification in stem cells. Biomacromolecules. 2012.
Duncan RK et al. Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium. Sci Rep. 2017.
Duncan RK et al. Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration. PLoS One. 2017.
Duncan RK et al. From Otic Induction to Hair Cell Production: Pax2-EGFP Cell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model. Stem Cell Dev. 2018.
Duncan RK et al. Matrigel is required for efficient differentiation of isolated, stem cell-derived otic vesicles into inner ear organoids. Stem Cell Res. 2021.
Feldman EL et al. Human neural stem cell transplantation into the corpus callosum of Alzheimer’s mice. Ann Clin Transl Neurol. 2017.
Feldman EL et al. Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS. Ann Clin Transl Neurol. 2018.
Feldman EL et al. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep. 2018.
Feldman EL et al. Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials. Expert Opin Investig Drugs. 2019.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2020.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2021.
Feldman EL et al. Diabetic neuropathy in children and youth: New and emerging risk factors. Pediatr Diabetes. 2021.
Feldman EL et al. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron. 2021.
Feldman EL et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Feldman EL et al. Immune-mediated vincristine-induced neuropathy: Unlocking therapies. J Exp Med. 2021.
Feldman EL et al. Lessons for clinical trial design in Friedreich’s ataxia. Lancet Neurol. 2021.
Feldman EL et al. High dietary fat consumption impairs axonal mitochondrial function in Vivo. J Neurosci. 2021.
Feldman EL et al. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. Faseb J. 2021.
Feldman EL et al. Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes. Ann Clin Transl Neurol. 2021.
Feldman EL et al. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight 2021.
Feldman EL et al. The determinants of complication trajectories in American Indians with type 2 diabetes. JCI Insight. 2021.
Feldman EL et al. Inclusion body myositis: small steps towards future advances. Lanc Rheum. 2021.
Feldman et al. Untargeted metabolomics yields insight into ALS disease mechanisms. J Neurol Neurosurg Psychiatry. 2020.
Feldman et al. Covid-19 and diabetes: A collision and collusion of two diseases. Diabetes. 2020.
Feldman et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Feldman et al. Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact. Neurosci Biobehav Rev. 2021.
Feldman et al. Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis. JAMA Neurol. 2021.
Feldman et al. Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology. Obesity (Silver Spring). 2021.
Feldman et al. Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy. Dis Model Mech. 2021.
Feldman et al. Nox, Nox, Are You There? the Role of NADPH Oxidases in the Peripheral Nervous System. Antioxid Redox Signal. 2022.
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Yang et al. Gait speed is a preoperative indicator of postoperative events after elective proximal aortic surgery. J Thorac Cardiovasc Surg. 2022.
Yang et al. Higher admission rates and in-hospital mortality for acute type A aortic dissection during Influenza season: a single center experience. Sci Rep. 2020.
Yang et al. Aortic progression and reintervention in patients with pathogenic variants after a thoracic aortic dissection. J Thorac Cardiovasc Surg. 2021.
Yang et al. Commentary: Does the STABILISE technique stabilize the aneurysm in chronic dissection?. J Thorac Cardiovasc Surg. 2021.
Yang et al. Commentary: Expanded options for dialysis-dependent patients requiring valve replacement in the transcatheter era. J Thorac Cardiovasc Surg. 2022.
Yang et al. Commentary: How aggressive should we be in a prophylactic surgery for patients with Loeys–Dietz or Marfan syndrome?. J Thorac Cardiovasc Surg. 2022.
Yang et al. Treatment of aortic valve endocarditis with stented or stentless valve. J Thorac Cardiovasc Surg. 2022.
Yang et al. Surgical Explantation of Transcatheter Aortic Bioprostheses: Balloon vs Self-Expandable Devices. Ann Thorac Surg. 2022.
Yang et al. The Clinical Impact of Implementation of a Multidisciplinary Endocarditis Team. Ann Thorac Surg. 2022.
Yang et al. Open Repair of Aortic Arch Mycotic Pseudoaneurysms With Distal Perfusion. Ann Thorac Surg. 2022.
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Yang et al. Aortic septotomy to optimize landing zones during thoracic endovascular aortic repair for chronic type B aortic dissection. J Thorac Cardiovasc Surg. 2023.
Yang et al. Y-incision Aortic Root Enlargement With Modified Aortotomy Upsizing the Annulus by 5 Valve Sizes. Ann Thorac Surg. 2022.
Yang et al. Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2022.
Yang et al. Early outcomes of the Y-incision technique to enlarge the aortic annulus 3 to 4 valve sizes. J Thorac Cardiovasc Surg. 2024.
Yang et al. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. J Clin Invest. 2022.
Yang et al. Poor long-term outcomes of intravenous drug users with infectious endocarditis. JTCVS Open. 2022.
Yang et al. Cardiac Reoperations in Patients With Transcatheter Aortic Bioprosthesis. Ann Thorac Surg. 2023.
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Yang et al. Bicuspid Aortic Valve-Associated Regulatory Regions Reveal GATA4 Regulation and Function during Human-Induced Pluripotent Stem Cell-Based Endothelial-Mesenchymal Transition – Brief Report. Arterioscler Thromb Vasc Biol. 2023.
Yang et al. Does Acute Type A Aortic Dissection Equal Emergency Aortic Surgery?. Ann Thorac Surg. 2023.
Yang et al. Registry of Aortic Diseases to Model Adverse Events and Progression (ROADMAP) in Uncomplicated Type B Aortic Dissection: Study Design and Rationale. Radiol Cardiothorac Imaging. 2022.
Yang et al. Aortic Valve Replacement vs Aortic Valve Replacement + Annular Enlargement: Apples to Oranges?. Ann Thorac Surg. 2024.
Yang et al. KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity. Int J Cancer. 2023.
Yang et al. Single-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT -Expressing Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2023.
Yang et al. Aortic valve replacement with Y-incision/rectangular patch aortic annular enlargement. Indian J Thorac Cardiovasc Surg. 2023.
Yang et al. Renal Dysfunction at Discharge and Long-Term Survival in Acute Type A Aortic Dissection. J Surg Res. 2024.
Yang et al. Reply from authors: Surgery follows mother nature. J Thorac Cardiovasc Surg. 2024.
Yang et al. Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects. Sci Transl Med. 2024.
Yang et al. Progression of distal aorta after endovascular fenestration/stenting in acute type A aortic dissection with malperfusion syndrome. JTCVS Open. 2023.

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