Micro/Nano Technology and Molecular Engineering
Micro- and nano-technology and molecular engineering research are concerned with the design and testing of microdevices which can affect the behavior of individual molecules or systems of molecules to perform specific functions. The nature of molecular interactions allows for an innumerable amount of potential applications.
Gary D. SmithMedicine
Aguilar CA et al. Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma. Stem Cell Reports. 2016.
Aguilar CA et al. Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury. Cell Death Discov. 2018.
Aguilar CA et al. Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. J Immunology. 2020.
Aguilar CA et al. Dissecting murine muscle stem cell aging through integrative genomic analysis. Cell Rep. 2020.
Aguilar CA et al. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight. 2020.
Aguilar CA et al. Engineered Tools to Study Intercellular Communication. Adv Sci (Weinh). 2021.
Aguilar et al. Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Commun Biol. 2020.
Bottino MC et al. A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics. J Biomed Mater Res B Appl Biomater. 2019.
Bottino MC et al. Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration. Acta Biomater. 2020.
Bottino MC et al. Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection Ablation. Biomacromolecules. 2020.
Bottino MC et al. The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers. Clin Oral Investig. 2021.
Bottino MC et al. Development and properties of endodontic resin sealers with natural oils. J Dent. 2021.
Bottino MC et al. Metformin-loaded nanospheres-laden photocrosslinkable gelatin hydrogel for bone tissue engineering. J Mech Behav Biomed Mater. 2021.
Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.
Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.
Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.
Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.
Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Chen YE et al. Translating Cardiovascular Genomics to Clinical Practice. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Biomimetic tubular scaffold with heparin conjugation for rapid degradation in in situ regeneration of a small diameter neoartery. Biomaterials. 2021.
Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Cohen et al. A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro. Surgery. 2021.
Cohen et al. Early biochemical response to parathyroidectomy for primary hyperparathyroidism and its predictive value for recurrent hypercalcemia and recurrent primary hyperparathyroidism. Surgery. 2021.
Cohen et al. Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics. Ann Surg. 2021.
Cohen et al. LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. Nat Cell Biol. 2021.
Fabiilli et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.
Fabiilli ML et al. Spatiotemporally-controlled transgene expression in hydroxyapatite-fibrin composite scaffolds using high intensity focused ultrasound. Biomaterials. 2019.
Fabiilli ML et al. Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation. Acta Biomater. 2019.
Fabiilli ML et al. Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds. Ultrason Sonochem. 2020.
Fabiilli ML et al. Spatially-directed cell migration in acoustically-responsive scaffolds via the controlled delivery of basic fibroblast growth factor. Acta Biomater. 2020.
Fabiilli ML et al. Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization. Soft Matter. 2020.
Fabiilli ML et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Stem-cell-based embryo models for fundamental research and translation. Nat Mater. 2021.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Kim et al. Observation of magneto-electric rectification at non-relativistic intensities. Nat Commun. 2020.
Kohn DH et al. Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A. 2009.
Kohn DH et al. Gene delivery via DNA incorporation within a biomimetic apatite coating. Biomaterials. 2009.
Kohn DH et al. PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol. 2016.
Kohn DH et al. Dual-functioning peptides discovered by phage display increase the magnitude and specificity of BMSC attachment to mineralized biomaterials. Biomaterials. 2017.
Kohn DH et al. Cell and material-specific phage display peptides increase iPS-MSC mediated bone and vasculature formation in vivo. Adv Healthc Mater. 2019.
Kretzler et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat Commun. 2020.
Kretzler et al. A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. Physiol Genomics. 2021.
Kretzler et al. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Lab Invest. 2021.
Kretzler et al. Nephrotic syndrome disease activity is proportional to its associated hypercoagulopathy. Thromb Res. 2021.
Kretzler et al. Patient perspectives and involvement in precision medicine research. Kidney Int. 2021.
Kretzler et al. Innovating and invigorating the clinical trial infrastructure for glomerular diseases. Kidney Int. 2021.
Kretzler et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 2021.
Kretzler et al. IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes. Diabetologia. 2021.
Kretzler et al. Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice. Clin Sci (Lond). 2021.
Kretzler et al. Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021.
Kretzler et al. Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building Meeting. Front Pharmacol. 2021.
Kretzler et al. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. J Clin Invest. 2021.
Kretzler et al. Renin-angiotensin system inhibition reverses the altered triacylglycerol metabolic network in diabetic kidney disease. Metabolomics. 2021.
Kretzler et al. Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. Nat Genet. 2021.
Kretzler et al.Transcriptome analysis of primary podocytes reveals novel calcium regulated regulatory networks. FASEB J. 2020
Kushner et al. Scaling of atomic layer etching of SiO2in fluorocarbon plasmas: Transient etching and surface roughness. J. Vac. Sci. Technol. 2021.
Kushner et al. Interactions between atmospheric pressure plasmas and metallic catalyst particles in packed bed reactors. J. Phys. D: Appl. Phys. 2021.
Kushner et al. Propagation of positive discharges in an air bubble having an embedded water droplet. Plasma Sources Sci. 2021.
Kushner et al. Propagation of atmospheric pressure plasmas through interconnected pores in dielectric materials. J Appl Phys. 2021.
Lahann et al. Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy. Nat Commun. 2020.
Lahann J et al. Nanoparticle Tracking Analysis of Polymer Nanoparticles in Blood Plasma. Part Part Syst Charact. 2021.
Lahann J et al. Cooperative Switching in Large‐Area Assemblies of Magnetic Janus Particles. Adv Funct Mater. 2020.
Lahann J et al. 3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures. Adv Mater. 2018.
Lahann J et al. Templated nanofiber synthesis via chemical vapor polymerization into liquid crystalline films. Science. 2018.
Lahann J et al. Engineered Fibrillar Fibronectin Networks as Three Dimensional Tissue Scaffolds. Adv Mater. 2019.
Lahann J et al. Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting. Macromol Rapid Commun. 2020.
Lahann J et al. Performance Fabrics Obtained by In Situ Growth of Metal-Organic Frameworks in Electrospun Fibers. ACS Appl Mater Interfaces. 2021.
Lahann J et al. 3D jet writing of mechanically actuated tandem scaffolds. Sci Adv. 2021.
Liu AP et al. A microfluidic pipette array for mechanophenotyping of cancer cells and mechanical gating of mechanosensitive channels. Lab Chip. 2015.
Liu AP et al. Cell spreading area regulates clathrin-coated pit dynamics on micropatterned substrate. Integr Biol (Camb). 2015.
Liu AP et al. New advances in probing cell-extracellular matrix interactions. Integr Biol (Camb). 2017.
Liu AP et al. The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration. APL Bioeng. 2018.
Liu AP et al. An adaptive synthetic cell based on mechanosensing, biosensing, and inducible gene circuits. ACS Synth Biol. 2019.
Liu AP et al. Engineering spatiotemporal organization and dynamics in synthetic cells. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021.
Liu AP et al. Myofibrillar Structural Variability Underlies Contractile Function in Stem Cell-Derived Cardiomyocytes. Stem Cell Reports. 2021.
Liu et al.Confinement Geometry Tunes Fascin-Actin Bundle Structures and Consequently the Shape of a Lipid Bilayer Vesicle. Front Mol Biosci. 2020
Mehta G et al. Personalized Medicine–Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids. Clin Cancer Res. 2017.
Mehta G et al. Integrated cancer tissue engineering models for precision medicine. PLoS One. 2019.
Mehta G et al. Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance. Neoplasia. 2019.
Mehta G et al. Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments. J Immunother Cancer. 2019.
Mehta G et al. Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor. Cancers (Basel). 2020.
Mehta G et al. Design and applications of surfaces that control the accretion of matter. Sci. 2021.
Moon JJ et al. Modularly Programmable Nanoparticle Vaccine Based on Polyethyleneimine for Personalized Cancer Immunotherapy. Adv Sci. 2021.
Moon JJ et al. Designer vaccine nanodiscs for personalized cancer immunotherapy. Nat Mater. 2017.
Moon JJ et al. Engineering strategies for personalized cancer immunotherapy: a paradigm shift. Nat Biomed Eng. 2019.
Moon JJ et al. Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice. J Clin Invest. 2021.
Moon JJ et al. Non-viral COVID-19 vaccine delivery systems. Adv Drug Deliv Rev. 2021.
Moon JJ et al. Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2. J Control Release. 2021.
Moon JJ et al. Modularly Programmable Nanoparticle Vaccine Based on Polyethyleneimine for Personalized Cancer Immunotherapy. Adv Sci (Weinh). 2021.
Moon JJ et al. Personalized combination nano-immunotherapy for robust induction and tumor infiltration of CD8+ T cells. Biomaterials. 2021.
Moon JJ et al. Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments. Front Pharmacol. 2021.
Moon JJ et al. Cancer nanomedicine for combination cancer immunotherapy. Nat Rev Mater. 2019.
Moon JJ et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Shikanov A et al. A View from the past into our collective future: the oncofertility consortium vision statement. J Assist Reprod Genet. 2021.
Shtein et al. Kirigami-Based Compliant Mechanism for Multiaxis Optical Tracking and Energy-Harvesting Applications. Adv Eng Mat. 2021.
Shtein M et al. Developable Rotationally Symmetric Kirigami-Based Structures as Sensor Platforms. Adv Mater. 2019.
Shtein M et al. Dynamic kirigami structures for integrated solar tracking. Nat Comm. 2017.
Shtein M et al. Printing of small molecular medicines from the vapor phase. Nat Comm. 2017.
Shtein M et al. An electric-eel-inspired soft power source from stacked hydrogels. Nature. 2017.
Shtein M et al. Chemical Vapor Jet Deposition of Parylene Polymer Films in Air. Macromolecules. 2015.
Smith et al. Lipidomic markers of sperm cryotolerance in cattle. Sci Rep. 2020.
Smith GD et al. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes. J Mol Cell Cardiol. 2016.
Smith GD et al. Targeted reactivation of FMR1 transcription in fragile X syndrome embryonic stem cells. Front Mol Neurosci. 2018.
Smith GD et al. Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line. Stem Cell Res. 2019.
Smith GD et al. Histone acetyltransferase MOF regulates fatty acid oxidation and cellular metabolism in cell fate determination. Cell Stem Cell. 2020.
Smith GD et al. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020.