Micro/Nano Technology and Molecular Engineering

Micro- and nano-technology and molecular engineering research are concerned with the design and testing of microdevices which can affect the behavior of individual molecules or systems of molecules to perform specific functions. The nature of molecular interactions allows for an innumerable amount of potential applications.

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Researchers

Carlos Aguilar

Engineering
Marco Bottino

Dentistry
Eugene Chen

Medicine
Mario Fabiilli

Medicine
Jianping Fu

Engineering
Katherine Gallagher

Medicine
Jinsang Kim

Engineering
David Kohn

Dentistry
Matthias Kretzler

Medicine
Mark Kushner

Engineering
Joerg Lahann

Engineering
Allen Liu

Engineering
Geeta Mehta

Engineering
James Moon

Pharmacy
Max Shtein

Engineering
Gary D. Smith

Medicine
James Weiland

Medicine

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Select Publications

Aguilar CA et al. Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma. Stem Cell Reports. 2016.
Aguilar CA et al. Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury. Cell Death Discov. 2018.
Aguilar CA et al. Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. J Immunology. 2020.
Aguilar CA et al. Dissecting murine muscle stem cell aging through integrative genomic analysis. Cell Rep. 2020.
Aguilar CA et al. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight. 2020.
Aguilar CA et al. Engineered Tools to Study Intercellular Communication. Adv Sci (Weinh). 2021.
Aguilar CA et al. Metabolipidomic profiling reveals an age-related deficiency of skeletal muscle pro-resolving mediators that contributes to maladaptive tissue remodeling. Aging Cell. 2021.
Aguilar CA et al. Sestrins regulate muscle stem cell metabolic homeostasis. Stem Cell Reports. 2021.
Aguilar et al. Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Commun Biol. 2020.
Aguilar et al. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci U S A. 2022.
Aguilar et al. Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma. Ann Surg. 2023.
Aguilar et al. Three-dimensional chromatin re-organization during muscle stem cell aging. Aging Cell. 2023.
Aguilar et al. Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss. JCI Insight. 2023.
Aguilar et al. Tracking of Nascent Matrix Deposition during Muscle Stem Cell Activation across Lifespan Using Engineered Hydrogels. Adv Biol (Weinh). 2024.
Bottino et al. Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction. Dent Mater. 2022.
Bottino et al. Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies. Clin Oral Investig. 2021.
Bottino et al. A Highly Ordered, Nanostructured Fluorinated CaP-Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration. Adv Healthc Mater. 2021.
Bottino et al. Dental education 2026: A scenario exploration. J Dent Educ. 2022.
Bottino et al. Scenario IV: Under-resourced but resilient and transformative. J Dent Educ. 2022.
Bottino et al. Do resin cement viscosity and ceramic surface etching influence the fatigue performance of bonded lithium disilicate glass-ceramic crowns?. Dent Mater. 2022.
Bottino et al. Unveiling the potential of melt electrowriting in regenerative dental medicine. Acta Biomater. 2023.
Bottino et al. Novel cinnamon-laden nanofibers as a potential antifungal coating for poly(methyl methacrylate) denture base materials. Clin Oral Investig. 2022.
Bottino et al. Engineering of Injectable Antibiotic-Laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation. Int J Mol Sci. 2022.
Bottino et al. Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review. Int Endod J. 2022.
Bottino et al. Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues. Bioact Mater. 2023.
Bottino et al. Natural monoterpenes-laden electrospun fibrous scaffolds for endodontic infection eradication. Odontology. 2023.
Bottino et al. Photocrosslinkable methacrylated gelatin hydrogel as a cell-friendly injectable delivery system for chlorhexidine in regenerative endodontics. Dent Mater. 2022.
Bottino et al. Thickness and internal adjustment of monolithic resin composite milled crowns: Effect on the load-bearing capacity under fatigue. J Mech Behav Biomed Mater. 2022.
Bottino et al. Advanced biomaterials for periodontal tissue regeneration. Genesis. 2022.
Bottino et al. Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration. Dent Mater. 2022.
Bottino et al. Development of functional fillers as a self-healing system for dental resin composite. J Dent. 2022.
Bottino et al. Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interface. ACS Appl Mater Interfaces. 2023.
Bottino et al. Next-generation biomaterials for dental pulp tissue immunomodulation. Dent Mater. 2023.
Bottino et al. Synthesis and characterization of calcium-releasing elastomeric resin-based endodontic sealers. Clin Oral Investig. 2023.
Bottino et al. Multifunctional and biodegradable methacrylated gelatin/Aloe vera nanofibers for endodontic disinfection and immunomodulation. Biomater Adv. 2023.
Bottino et al. Effect of desensitizing agents on the resin bond strength to sound dentin. Odontology. 2024.
Bottino et al. GelMA/TCP nanocomposite scaffold for vital pulp therapy. Acta Biomater. 2024.
Bottino et al. Citric Acid Conditioning as an Alternative to EDTA for Growth Factors Release and Stem Cell Response in Regenerative Endodontics: A Systematic Review of In Vitro Studies. J Endod. 2024.
Bottino et al. The rhythms of histones in regeneration: The epigenetic modifications determined by clock genes. Exp Dermatol. 2024.
Bottino et al. Recent advances in additive manufacturing of patient-specific devices for dental and maxillofacial rehabilitation. Dent Mater. 2024.
Bottino et al. Injectable Tissue-Specific Hydrogel System for Pulp–Dentin Regeneration. J Dent Res. 2024.
Bottino et al. Functionalization of PCL-Based Fiber Scaffolds with Different Sources of Calcium and Phosphate and Odontogenic Potential on Human Dental Pulp Cells. J Funct Biomater. 2024.
Bottino et al. Strontium-Doped Bioglass-Laden Gelatin Methacryloyl Hydrogels for Vital Pulp Therapy. J Funct Biomater. 2024.
Bottino et al. Biodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering. J Biomed Mater Res B Appl Biomater. 2024.
Bottino et al. Amino Acid-Based Poly(ester urea) Biodegradable Membrane for Guided Bone Regeneration. ACS Appl Mater Interfaces. 2024.
Bottino et al. Adhesion to a new CAD/CAM resin composite: Effects of the machining roughness simulation, surface treatments, and long-term aging. Int J Adhes Adhes. 2022.
Bottino et al. Effect of Co, Cu, and Zn ions on the bioactivity and antibacterial properties of a borate bioactive glass. J Non-Cryst Solids. 2023.
Bottino MC et al. A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics. J Biomed Mater Res B Appl Biomater. 2019.
Bottino MC et al. Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration. Acta Biomater. 2020.
Bottino MC et al. Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection Ablation. Biomacromolecules. 2020.
Bottino MC et al. The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers. Clin Oral Investig. 2021.
Bottino MC et al. Development and properties of endodontic resin sealers with natural oils. J Dent. 2021.
Bottino MC et al. Metformin-loaded nanospheres-laden photocrosslinkable gelatin hydrogel for bone tissue engineering. J Mech Behav Biomed Mater. 2021.
Bottino MC et al. Alumina particle air-abrasion and aging effects: Fatigue behavior of CAD/CAM resin composite crowns and flexural strength evaluations. J Mech Behav Biomed Mater. 2021.
Chen et al. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovasc Drugs Ther. 2021.
Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.
Chen et al. Impact of donor blood type on outcomes after prolonged allograft ischemic times. J Thorac Cardiovasc Surg. 2022.
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen et al. Risk factors for heart transplant survival with greater than 5 h of donor heart ischemic time. J Card Surg. 2021.
Chen et al. Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31/FIH1/HIF-1α pathway. J Mol Cell Cardiol. 2022.
Chen et al. RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II. Pharmacol Res. 2022.
Chen et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. Redox Biol. 2022.
Chen et al. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. J Clin Invest. 2022.
Chen et al. Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis. Cells. 2022.
Chen et al. Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Adv Sci (Weinh). 2023.
Chen et al. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates. Cell Metab. 2023.
Chen et al. PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm. JCI Insight. 2023.
Chen et al. Circular RNA as Therapeutic Targets in Atherosclerosis: Are We Running in Circles?. J Clin Med. 2023.
Chen et al. SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies. Cells. 2024.
Chen et al. Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis. Nat Metab. 2024.
Chen YE et al. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration. Biomaterials. 2015.
Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.
Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.
Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.
Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.
Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Chen YE et al. Translating Cardiovascular Genomics to Clinical Practice. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Improving the genome assembly of rabbits with long-read sequencing. Genomics. 2021.
Chen YE et al. Biomimetic tubular scaffold with heparin conjugation for rapid degradation in in situ regeneration of a small diameter neoartery. Biomaterials. 2021.
Chen YE et al. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021.
Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Cohen et al. A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro. Surgery. 2021.
Cohen et al. Early biochemical response to parathyroidectomy for primary hyperparathyroidism and its predictive value for recurrent hypercalcemia and recurrent primary hyperparathyroidism. Surgery. 2021.
Cohen et al. Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics. Ann Surg. 2021.
Cohen et al. LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. Nat Cell Biol. 2021.
Cohen et al. Identification of novel lipid metabolic biomarkers associated with poor adrenocortical carcinoma prognosis using integrated bioinformatics. Surgery. 2022.
Cohen et al. Re-evaluation of combinational efficacy and synergy of the italian protocol in vitro: Are we truly optimizing benefit or permitting unwanted toxicity?. Biomedicines. 2021.
Fabiili et al. Real-time spatiotemporal characterization of mechanics and sonoporation of acoustic droplet vaporization in acoustically responsive scaffolds. Appl Phys Lett. 2023.
Fabiilli et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.
Fabiilli et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.
Fabiilli et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Fabiilli et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.
Fabiilli et al. Slow-Flow Ultrasound Localization Microscopy Using Recondensation of Perfluoropentane Nanodroplets. Ultrasound Med Biol. 2022.
Fabiilli et al. Multi-time scale characterization of acoustic droplet vaporization and payload release of phase-shift emulsions using high-speed microscopy. Ultrason Sonochem. 2022.
Fabiilli et al. Pressure Measurement in a Bladder Phantom Using Contrast-Enhanced Ultrasonography – A Path to a Catheter-Free Voiding Cystometrogram. Invest Radiol. 2023.
Fabiilli et al. Ultrasound Contrast Stability for Urinary Bladder Pressure Measurement. Ultrasound Med Biol. 2023.
Fabiilli et al. Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber Model In Vivo. Tissue Eng Part C Methods. 2024.
Fabiilli et al. The radial dynamics and acoustic emissions of phase-shift droplets are impacted by mechanical properties of tissue-mimicking hydrogels. Ultrason Sonochem. 2024.
Fabiilli et al. Acoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery. J Control Release. 2024.
Fabiilli ML et al. Spatiotemporally-controlled transgene expression in hydroxyapatite-fibrin composite scaffolds using high intensity focused ultrasound. Biomaterials. 2019.
Fabiilli ML et al. Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation. Acta Biomater. 2019.
Fabiilli ML et al. Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds. Ultrason Sonochem. 2020.
Fabiilli ML et al. Spatially-directed cell migration in acoustically-responsive scaffolds via the controlled delivery of basic fibroblast growth factor. Acta Biomater. 2020.
Fabiilli ML et al. Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization. Soft Matter. 2020.
Fabiilli ML et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.
Fabilli et al. Ultra-high-speed dynamics of acoustic droplet vaporization in soft biomaterials: Effects of viscoelasticity, frequency, and bulk boiling point. Ultrason Sonochem. 2024.
Fu et al. Branching development of early post-implantation human embryonic-like tissues in 3D stem cell culture. Biomaterials. 2021.
Fu et al. Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation. Nano Today. 2021.
Fu et al. Elucidating the behavior of trophectoderm derivatives in mouse implantation. Dev Cell. 2022.
Fu et al. Engineering multiscale structural orders for high-fidelity embryoids and organoids. Cell Stem Cell. 2022.
Fu et al. In vitro germ cell induction from fertile and infertile monozygotic twin research participants. Cell Rep Med. 2022.
Fu et al. Modeling development using microfluidics: bridging gaps to foster fundamental and translational research. Curr Opin Genet Dev. 2023.
Fu et al. Why researchers should use human embryo models with caution. Nature. 2023.
Fu et al. A Definition of Neuromodulation and Classification of Implantable Electrical Modulation for Chronic Pain. Neuromodulation. 2024.
Fu et al. Changing the public perception of human embryology. Nat Cell Bio. 2023.
Fu et al. The role of copy number variants in the genetic architecture of common familial epilepsies. Epilepsia. 2024.
Fu et al. A patterned human neural tube model using microfluidic gradients. Nature. 2024.
Fu et al. Metabolic-Glycoengineering-Enabled Molecularly Specific Acoustic Tweezing Cytometry for Targeted Mechanical Stimulation of Cell Surface Sialoglycans. Angew Chem Int Ed Engl. 2024.
Fu et al. Toward developing human organs via embryo models and chimeras. Cell. 2024.
Fu et al. Criteria for the standardization of stem-cell-based embryo models. Nat Cell Biol. 2024.
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Fu J et al. Stem-cell-based embryo models for fundamental research and translation. Nat Mater. 2021.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Kim et al. Heavy atom oriented orbital angular momentum manipulation in metal-free organic phosphors. Chem Sci. 2022.
Kim et al. Observation of magneto-electric rectification at non-relativistic intensities. Nat Commun. 2020.
Kim et al. Chaotic Organic Crystal Phosphorescent Patterns for Physical Unclonable Functions. Adv Mater. 2021.
Kim et al. Highly sensitive and quantitative biodetection with lipid-polymer hybrid nanoparticles having organic room-temperature phosphorescence. Biosens Bioelectron. 2022.
Kim et al. Dihydroxy Indole-free Poly(catecholamine) for Smooth Surface Coating with Amine Functionality. ACS Appl Polym Mater. 2023.
Kohn DH et al. Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A. 2009.
Kohn DH et al. Gene delivery via DNA incorporation within a biomimetic apatite coating. Biomaterials. 2009.
Kohn DH et al. PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol. 2016.
Kohn DH et al. Dual-functioning peptides discovered by phage display increase the magnitude and specificity of BMSC attachment to mineralized biomaterials. Biomaterials. 2017.
Kohn DH et al. Cell and material-specific phage display peptides increase iPS-MSC mediated bone and vasculature formation in vivo. Adv Healthc Mater. 2019.
Kohn DH et al. Translating Dental, Oral, and Craniofacial Regenerative Medicine Innovations to the Clinic through Interdisciplinary Commercial Translation Architecture. J Dent Res. 2021.
Kohn et al. Region-specific associations among tissue-level mechanical properties, porosity, and composition in human male femora. J Biomech. 2022.
Kohn et al. Divergent mechanical properties of older human male femora reveal unique combinations of morphological and compositional traits contributing to low strength. Bone. 2022.
Kohn et al. Sex and External Size Specific Limitations in Assessing Bone Health From Adult Hand Radiographs. JBMR Plus. 2022.
Kohn et al. The Contribution of Perilacunar Composition and Mechanical Properties to Whole-Bone Mechanical Outcomes in Streptozotocin-Induced Diabetes. Calcif Tissue Int. 2023.
Kohn et al. Beyond bone volume: Understanding tissue-level quality in healing of maxillary vs. femoral defects. Acta Biomater. 2024.
Kretzler et al Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease. Diabetologia. 2022.
Kretzler et al. The clinical application of urine soluble CD163 in ANCA-associated vasculitis. J Am Soc Nephrol. 2021.
Kretzler et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat Commun. 2020.
Kretzler et al. A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. Physiol Genomics. 2021.
Kretzler et al. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Lab Invest. 2021.
Kretzler et al. Nephrotic syndrome disease activity is proportional to its associated hypercoagulopathy. Thromb Res. 2021.
Kretzler et al. Patient perspectives and involvement in precision medicine research. Kidney Int. 2021.
Kretzler et al. Innovating and invigorating the clinical trial infrastructure for glomerular diseases. Kidney Int. 2021.
Kretzler et al. APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis. Pediatr Nephrol. 2021.
Kretzler et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 2021.
Kretzler et al. IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes. Diabetologia. 2021.
Kretzler et al. Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice. Clin Sci (Lond). 2021.
Kretzler et al. Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021.
Kretzler et al. Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building Meeting. Front Pharmacol. 2021.
Kretzler et al. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis. Kidney Int. 2021.
Kretzler et al. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. J Clin Invest. 2021.
Kretzler et al. Comprehensive search for novel circulating mirnas and axon guidance pathway proteins associated with risk of eskd in diabetes. J Am Soc Nephrol. 2021.
Kretzler et al. Renin-angiotensin system inhibition reverses the altered triacylglycerol metabolic network in diabetic kidney disease. Metabolomics. 2021.
Kretzler et al. Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy. JCI Insight. 2021.
Kretzler et al. Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes. Am J Kidney Dis. 2022.
Kretzler et al. Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney. Am J Transplant. 2022.
Kretzler et al. Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome. Am J Kidney Dis. 2022.
Kretzler et al. A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project. Am J Kidney Dis. 2022.
Kretzler et al. A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis. Kidney Int. 2022.
Kretzler et al. Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants. Kidney Int. 2022.
Kretzler et al. Unsupervised machine learning for identifying important visual features through bag-of-words using histopathology data from chronic kidney disease. Sci Rep. 2022.
Kretzler et al. Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation. Kidney Int. 2022.
Kretzler et al. Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes. Diabetes Care. 2022.
Kretzler et al. Micro-dissection and integration of long and short reads to create a robust catalog of kidney compartment-specific isoforms. PLoS Comput Biol. 2022.
Kretzler et al. Molecular Characterization of Membranous Nephropathy. J Am Soc Nephrol. 2022.
Kretzler et al. Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis. J Am Soc Nephrol. 2022.
Kretzler et al. A reference tissue atlas for the human kidney. Sci Adv. 2022.
Kretzler et al. The Michigan O’Brien Kidney Research Center: transforming translational kidney research through systems biology. Am J Physiol Renal Physiol. 2022.
Kretzler et al. Molecular programs associated with glomerular hyperfiltration in early diabetic kidney disease. Kidney Int. 2022.
Kretzler et al. Authors’ Reply: In Silico–Based Approach to the Discovery of New Antigens in Membranous Nephropathy. J Am Soc Nephrol. 2022.
Kretzler et al. Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease. Am J Kidney Dis. 2023.
Kretzler et al. Activation of Stimulator of IFN Genes (STING) Causes Proteinuria and Contributes to Glomerular Diseases. J Am Soc Nephrol. 2022.
Kretzler et al. Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease. Diabetes. 2022.
Kretzler et al. Viral associations with kidney disease diagnosis and altered kidney metatranscriptome by kidney function. Kidney Int. 2023.
Kretzler et al. Present and future directions in diabetic kidney disease. J Diabetes Complications. 2022.
Kretzler et al. Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis. Kidney Int. 2023.
Kretzler et al. Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease. Nat Commun. 2022.
Kretzler et al. Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network. Am J Kidney Dis. 2023.
Kretzler et al. SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes. J Clin Invest. 2023.
Kretzler et al. The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease. J Biol Chem. 2023.
Kretzler et al. Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes. Clin J Am Soc Nephrol. 2023.
Kretzler et al. The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome—a NEPTUNE cohort study. Pediatr Nephrol. 2023.
Kretzler et al. ARF6 is a host factor for SARS-CoV-2 infection in vitro. J Gen Virol. 2023.
Kretzler et al. An atlas of healthy and injured cell states and niches in the human kidney. Nature. 2023.
Kretzler et al. Dietary interventions improve diabetic kidney disease, but not peripheral neuropathy, in a db/db mouse model of type 2 diabetes. FASEB J. 2023.
Kretzler et al. Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes. Kidney Int. 2023.
Kretzler et al. Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients. J Clin Invest. 2023.
Kretzler et al. Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study. Am J Kidney Dis. 2024.
Kretzler et al. Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project. Am J Kidney Dis. 2024.
Kretzler et al. Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease. Am J Physiol Renal Physiol. 2024.
Kretzler et al. Interactive Effects of Empagliflozin and Hyperglycemia on Urinary Amino Acids in Individuals With Type 1 Diabetes. Diabetes. 2024.
Kretzler et al. TRPC6 Inhibitor BI 764198 in Focal Segmental Glomerulosclerosis: Phase 2 Study Design. Kidney Int Rep. 2023.
Kretzler et al. Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today. Kidney Int. 2024.
Kretzler et al. Multi-omics data integration shines a light on the renal medulla. Kidney Int. 2024.
Kretzler et al. Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine. Kidney Int. 2024.
Kretzler et al. The authors reply. Kidney Int. 2024.
Kretzler et al. Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury. Cell Rep. 2024.
Kretzler et al. Identification of kidney cell types in scRNA-seq and snRNA-seq data using machine learning algorithms. Heliyon. 2024.
Kretzler et al. Development and evaluation of deep learning–based segmentation of histologic structures in the kidney cortex with multiple histologic stains. Kidney Int. 2021.
Kretzler et al. Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. Nat Genet. 2021.
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