Medical Devices/Artificial Organs
Research in medical devices and artificial organs range from basic research to understand molecular and cellular mechanisms to the development of off-the-shelf implantable devices to restore physiological function or to promote the regeneration of the patient’s own tissues.
Bottino et al. Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction. Dent Mater. 2022.
Bottino et al. Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies. Clin Oral Investig. 2021.
Bottino et al. A Highly Ordered, Nanostructured Fluorinated CaP-Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration. Adv Healthc Mater. 2021.
Bottino et al. Dental education 2026: A scenario exploration. J Dent Educ. 2022.
Bottino et al. Scenario IV: Under-resourced but resilient and transformative. J Dent Educ. 2022.
Bottino et al. Novel cinnamon-laden nanofibers as a potential antifungal coating for poly(methyl methacrylate) denture base materials. Clin Oral Investig. 2022.
Bottino et al. Engineering of Injectable Antibiotic-Laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation. Int J Mol Sci. 2022.
Bottino et al. Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review. Int Endod J. 2022.
Bottino MC et al. A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics. J Biomed Mater Res B Appl Biomater. 2019.
Bottino MC et al. Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration. Acta Biomater. 2020.
Bottino MC et al. Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection Ablation. Biomacromolecules. 2020.
Bottino MC et al. The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers. Clin Oral Investig. 2021.
Bottino MC et al. Development and properties of endodontic resin sealers with natural oils. J Dent. 2021.
Bottino MC et al. Metformin-loaded nanospheres-laden photocrosslinkable gelatin hydrogel for bone tissue engineering. J Mech Behav Biomed Mater. 2021.
Bottino MC et al. Alumina particle air-abrasion and aging effects: Fatigue behavior of CAD/CAM resin composite crowns and flexural strength evaluations. J Mech Behav Biomed Mater. 2021.
Buchman et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Buchman et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Chen et al. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovasc Drugs Ther. 2021.
Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen et al. Risk factors for heart transplant survival with greater than 5 h of donor heart ischemic time. J Card Surg. 2021.
Chen et al. Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31/FIH1/HIF-1α pathway. J Mol Cell Cardiol. 2022.
Chen et al. RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II. Pharmacol Res. 2022.
Chen et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. Redox Biol. 2022.
Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.
Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.
Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.
Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.
Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Chen YE et al. Translating Cardiovascular Genomics to Clinical Practice. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Improving the genome assembly of rabbits with long-read sequencing. Genomics. 2021.
Chen YE et al. Biomimetic tubular scaffold with heparin conjugation for rapid degradation in in situ regeneration of a small diameter neoartery. Biomaterials. 2021.
Chen YE et al. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021.
Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Cohen et al. A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro. Surgery. 2021.
Cohen et al. Early biochemical response to parathyroidectomy for primary hyperparathyroidism and its predictive value for recurrent hypercalcemia and recurrent primary hyperparathyroidism. Surgery. 2021.
Cohen et al. Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics. Ann Surg. 2021.
Cohen et al. LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. Nat Cell Biol. 2021.
Edwards et al. Dental students’ OMFS-related experiences and interest in OMFS careers: An exploration. J Dent Educ. 2021.
Edwards et al. Squamous Cell Carcinoma of the Tongue in Young Patients: A Case Series and Literature Review. J Oral Maxillofac Surg. 2021.
Edwards et al. Comparisons of orthodontic residents’ performance and attitudes using 2D, 3D, and virtual reality surgical simulation methods. J Dent Educ. 2021.
Edwards et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Edwards et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Edwards et al. Clinical Practice Trends and Postoperative Outcomes in Primary Cleft Rhinoplasty. Cleft Palate Craniofac J. 2022.
Feinberg SE et al. Tissue engineering of lips and muco-cutaneous junctions: in vitro development of tissue engineered constructs of oral mucosa and skin for lip reconstruction. Tissue Eng Part C Methods. 2012.
Feinberg SE et al. Intraoral grafting of tissue-engineered human oral mucosa. Int J Oral Maxillofac Implants. 2013.
Feinberg SE et al. Fabrication of Large Size Ex Vivo-Produced Oral Mucosal Equivalents for Clinical Application. Tissue Eng Part C Methods. 2015.
Feinberg SE et al. In Vitro Development of a Mucocutaneous Junction for Lip Reconstruction. J Oral Maxillofac Surg. 2016.
Feinberg SE et al. Soft Tissue Engineering. Oral Maxillofac Surg Clin North Am. 2017.
Green et al. Tracheal agenesis: Esophageal airway support with a 3-dimensional–printed bioresorbable splint. JTCVS Tech. 2021.
Green et al. Addressing the Pandemic Training Deficiency: Filling the Void with Simulation in Facial Reconstruction. Laryngoscope. 2021.
Green GE et al. Bioresorbable Airway Splint Created with a Three-Dimensional Printer. N Engl J Med. 2013.
Green GE et al. Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients. Sci Transl Med. 2015.
Green GE et al. Regulatory Considerations in the Design and Manufacturing of Implantable 3D-Printed Medical Devices. Clin Transl Sci. 2015.
Green GE et al. A 3D-printed Lateral Skull Base Implant for Repair of Tegmen Defects. Otol Neurotol. 2020.
Green GE et al. Co-culture of adipose-derived stem cells and chondrocytes on three-dimensionally printed bioscaffolds for craniofacial cartilage engineering. Laryngoscope. 2018.
Green GE et al. Modified Minerva Cervical Thoracic Orthosis for Postoperative Management of Cricotracheal Resection. Ear Nose Throat J. 2021.
Green GE et al. Competency-Based Assessment Tool for Pediatric Esophagoscopy: International Modified Delphi Consensus. Laryngoscope. 2021.
Green GE et al. Characterization of noise exposure in places of worship. Appl Acoust. 2021.
Kemp et al. The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals. J Vis Exp. 2022.
Kemp et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Kemp et al. “Decreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)”. Ann Vasc Surg. 2022.
Kemp SWP et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Kruger et al. Acupressure for cancer-fatigue in ovarian cancer survivor (The AcuOva Study): A community-based clinical trial study protocol examining the impact of self-acupressure on persistent cancer related fatigue in ovarian cancer survivors. Contemp Clin Trials. 2021.
Kruger et al. Reply by Authors. J Urol. 2022.
Lempka et al. The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation. Neuromodulation. 2021.
Lempka et al. Quantitative Sensory Testing of Spinal Cord and Dorsal Root Ganglion Stimulation in Chronic Pain Patients. Neuromodulation. 2021.
Lempka et al. Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action. J Pain. 2022.
Lempka et al. Neural Recruitment During Conventional, Burst, and 10-kHz Spinal Cord Stimulation for Pain. J Pain. 2022.
Lempka et al. Augmented Transcutaneous Stimulation Using an Injectable Electrode: A Computational Study. Front Bioeng Biotechnol. 2021.
Love et al. Swellable catheters based on a dynamic expanding inner diameter. J Mater Sci Mater Med. 2021.
Love et al. Development of a Microcontroller-Based, Small-Scale Rotational Fiber Collection Device. J Chem Educ. 2021.
Love et al. Dewatering of super absorbent polymers: Alternatives to thermal desorption by liquid phase extraction using dimethyl ether. Resour Conserv Recy. 2021.
Mehta et al. Atovaquone: An Inhibitor of Oxidative Phosphorylation as Studied in Gynecologic Cancers. Cancers (Basel). 2022.
Mehta et al. The MEK1/2 pathway as a therapeutic target in high-grade serous ovarian carcinoma. Cancers (Basel). 2021.
Mehta et al. Injectable three-dimensional tumor microenvironments to study mechanobiology in ovarian cancer. Acta Biomater. 2022.
Mehta G et al. Personalized Medicine–Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids. Clin Cancer Res. 2017.
Mehta G et al. Integrated cancer tissue engineering models for precision medicine. PLoS One. 2019.
Mehta G et al. Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance. Neoplasia. 2019.
Mehta G et al. Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments. J Immunother Cancer. 2019.
Mehta G et al. Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor. Cancers (Basel). 2020.
Mehta G et al. Personalized models of heterogeneous 3D epithelial tumor microenvironments: Ovarian cancer as a model. Acta Biomater. 2021.
Mehta G et al. Design and applications of surfaces that control the accretion of matter. Sci. 2021.
Shea et al. Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering. Lancet Diabetes Endocrinol. 2021.
Shea et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea et al. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci U S A. 2022.
Shea LD et al. Microporous scaffolds support assembly and differentiation of pancreatic progenitors into ß-cell clusters. Acta Biomater. 2019.
Shea LD et al. Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2019.
Shea LD et al. Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. Tissue Eng Part A. 2020.
Shea LD et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea LD et al. An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides. J Control Release. 2021.
Shea LD et al. Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials. 2021.
Shea LD et al. Cargo-free immunomodulatory nanoparticles combined with anti-PD-1 antibody for treating metastatic breast cancer. Biomaterials. 2021.
Shea LD et al. IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury. Biotechnol Bioeng. 2021.
Shikanov A et al. Synthetic hydrogel supports the function and regeneration of artificial ovarian tissue in mice. NPJ Regen Med. 2016.
Shikanov A et al. Adipose-derived stem cell-secreted promote survival, growth and maturation of early-stage murine follicles. Stem Cell Res Ther. 2019.
Shikanov A et al. A mouse model to investigate the impact of testosterone therapy on reproduction in transgender men. Hum Reprod. 2019.
Shikanov A et al. Synergy of Paracrine Signaling During Early-Stage Mouse Ovarian Follicle Development In Vitro. Cell Mol Bioeng. 2018.
Shikanov A et al. A View from the past into our collective future: the oncofertility consortium vision statement. J Assist Reprod Genet. 2021.
Shikanov A et al. Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation. Acta Biomater. 2021.
Shikanov A et al. Swellable catheters based on a dynamic expanding inner diameter. J Mater Sci Mater Med. 2021.
Shikanov A et al. TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells. JCI Insight. 2021.
Shikanov et al. Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq. Dev Cell. 2022.
Shtein et al. Kirigami-Based Compliant Mechanism for Multiaxis Optical Tracking and Energy-Harvesting Applications. Adv Eng Mat. 2021.
Shtein M et al. Developable Rotationally Symmetric Kirigami-Based Structures as Sensor Platforms. Adv Mater. 2019.
Shtein M et al. Dynamic kirigami structures for integrated solar tracking. Nat Comm. 2017.
Shtein M et al. Printing of small molecular medicines from the vapor phase. Nat Comm. 2017.
Shtein M et al. An electric-eel-inspired soft power source from stacked hydrogels. Nature. 2017.
Shtein M et al. Chemical Vapor Jet Deposition of Parylene Polymer Films in Air. Macromolecules. 2015.
Stegemann et al. Aseptic and septic prosthetic joint loosening: Impact of biomaterial wear on immune cell function, inflammation, and infection. Biomaterials. 2021.
Stegemann et al. Fabrication and characterization of osteogenic function of progenitor cell-laden gelatin microcarriers. J Biomed Mater Res B Appl Biomater. 2022.
Stegemann JP et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
Stegemann JP et al. Resonant acoustic rheometry for non-contact characterization of viscoelastic biomaterials. Biomaterials. 2021.
Weiland et al. Spatial Transcriptomics as a Novel Approach to Redefine Electrical Stimulation Safety. Front Neurosci. 2022.
Weiland et al. Retinal ganglion cell desensitization is mitigated by varying parameter constant excitation pulse trains. Front Cell Neurosci. 2022.
Zopf DA et al. Bioresorbable airway splint created with a three-dimensional printer. N Engl J Med. 2013.
Zopf DA et al. Computer aided-designed, 3-dimensionally printed porous tissue bioscaffolds for craniofacial soft tissue reconstruction. Otolaryngol Head Neck Surg. 2014.
Zopf DA et al. A multidisciplinary international collaborative implementing low cost, high fidelity 3D printed airway models to enhance Ethiopian anesthesia resident emergency cricothyroidotomy skills. Int J Pediatr Otorhinolaryngol. 2018.
Zopf DA et al. Anatomic-Based Design, Manufacturing, and Preclinical Assessment of a Novel 3D-Printed Bioscaffold for Total Nasal Reconstruction. Facial Plast Surg Aesthet Med. 2020.
Zopf DA et al. Multi-institutional Comparison of Temporal Bone Models: A Collaboration of the AAO-HNSF 3D-Printed Temporal Bone Working Group. Otolaryngol Head Neck Surg. 2021.
Zopf DA et al. Hybrid Three-Dimensional-Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications. Laryngoscope. 2020.
Zopf et al. Preclinical assessment of clinically streamlined, 3D-printed, biocompatible single- and two-stage tissue scaffolds for ear reconstruction. J Biomed Mater Res B Appl Biomater. 2021.
Zopf et al. Development of a novel mandibular distraction osteogenesis simulator using Computer Aided Design and 3D printing. Int J Pediatr Otorhinolaryngol. 2021.
Zopf et al. Adoption of Telemedicine for Multidisciplinary Care in Pediatric Otolaryngology. Ann Otol Rhinol Laryngol. 2021.
Zopf et al. Early preclinical evaluation of a novel, computer aided designed, 3D printed, bioresorbable posterior cricoid scaffold. Int J Pediatr Otorhinolaryngol. 2021.
Zopf et al. Starting a medical 3D printing lab for otolaryngology-head and neck surgery collaboration. Am J Otolaryngol. 2022.
Zopf et al. Neurobehavioral morbidity of pediatric mild sleep-disordered breathing and obstructive sleep apnea. Sleep. 2022.