Medical Devices/Artificial Organs

Research in medical devices and artificial organs range from basic research to understand molecular and cellular mechanisms to the development of off-the-shelf implantable devices to restore physiological function or to promote the regeneration of the patient’s own tissues.

Join Our Research

Researchers

Marco Bottino

Dentistry
Steven Buchman

Medicine
Eugene Chen

Medicine
Sean Edwards

Dentistry
Stephen Feinberg

Dentistry
Glenn Green

Medicine
Stephen Kemp

Medicine
Grant Kruger

Engineering
Brian Love

Engineering
Geeta Mehta

Engineering
Lonnie Shea

Engineering
Ariella Shikanov

Engineering
Max Shtein

Engineering
James Weiland

Medicine
David Zopf

Medicine

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Select Publications

Bottino et al. Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction. Dent Mater. 2022.
Bottino et al. Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies. Clin Oral Investig. 2021.
Bottino et al. A Highly Ordered, Nanostructured Fluorinated CaP-Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration. Adv Healthc Mater. 2021.
Bottino et al. Dental education 2026: A scenario exploration. J Dent Educ. 2022.
Bottino et al. Scenario IV: Under-resourced but resilient and transformative. J Dent Educ. 2022.
Bottino et al. Do resin cement viscosity and ceramic surface etching influence the fatigue performance of bonded lithium disilicate glass-ceramic crowns?. Dent Mater. 2022.
Bottino et al. Unveiling the potential of melt electrowriting in regenerative dental medicine. Acta Biomater. 2023.
Bottino et al. Novel cinnamon-laden nanofibers as a potential antifungal coating for poly(methyl methacrylate) denture base materials. Clin Oral Investig. 2022.
Bottino et al. Engineering of Injectable Antibiotic-Laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation. Int J Mol Sci. 2022.
Bottino et al. Influence of ethylenediaminetetraacetic acid on regenerative endodontics: A systematic review. Int Endod J. 2022.
Bottino et al. Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues. Bioact Mater. 2023.
Bottino et al. Natural monoterpenes-laden electrospun fibrous scaffolds for endodontic infection eradication. Odontology. 2023.
Bottino et al. Photocrosslinkable methacrylated gelatin hydrogel as a cell-friendly injectable delivery system for chlorhexidine in regenerative endodontics. Dent Mater. 2022.
Bottino et al. Thickness and internal adjustment of monolithic resin composite milled crowns: Effect on the load-bearing capacity under fatigue. J Mech Behav Biomed Mater. 2022.
Bottino et al. Advanced biomaterials for periodontal tissue regeneration. Genesis. 2022.
Bottino et al. Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration. Dent Mater. 2022.
Bottino et al. Development of functional fillers as a self-healing system for dental resin composite. J Dent. 2022.
Bottino et al. Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interface. ACS Appl Mater Interfaces. 2023.
Bottino et al. Next-generation biomaterials for dental pulp tissue immunomodulation. Dent Mater. 2023.
Bottino et al. Synthesis and characterization of calcium-releasing elastomeric resin-based endodontic sealers. Clin Oral Investig. 2023.
Bottino et al. Multifunctional and biodegradable methacrylated gelatin/Aloe vera nanofibers for endodontic disinfection and immunomodulation. Biomater Adv. 2023.
Bottino et al. GelMA/TCP nanocomposite scaffold for vital pulp therapy. Acta Biomater. 2024.
Bottino et al. Citric Acid Conditioning as an Alternative to EDTA for Growth Factors Release and Stem Cell Response in Regenerative Endodontics: A Systematic Review of In Vitro Studies. J Endod. 2024.
Bottino et al. The rhythms of histones in regeneration: The epigenetic modifications determined by clock genes. Exp Dermatol. 2024.
Bottino et al. Adhesion to a new CAD/CAM resin composite: Effects of the machining roughness simulation, surface treatments, and long-term aging. Int J Adhes Adhes. 2022.
Bottino et al. Effect of Co, Cu, and Zn ions on the bioactivity and antibacterial properties of a borate bioactive glass. J Non-Cryst Solids. 2023.
Bottino MC et al. A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics. J Biomed Mater Res B Appl Biomater. 2019.
Bottino MC et al. Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration. Acta Biomater. 2020.
Bottino MC et al. Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection Ablation. Biomacromolecules. 2020.
Bottino MC et al. The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers. Clin Oral Investig. 2021.
Bottino MC et al. Development and properties of endodontic resin sealers with natural oils. J Dent. 2021.
Bottino MC et al. Metformin-loaded nanospheres-laden photocrosslinkable gelatin hydrogel for bone tissue engineering. J Mech Behav Biomed Mater. 2021.
Bottino MC et al. Alumina particle air-abrasion and aging effects: Fatigue behavior of CAD/CAM resin composite crowns and flexural strength evaluations. J Mech Behav Biomed Mater. 2021.
Buchman et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Buchman et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Buchman et al. Institutional trends in opioid prescribing and utilization after primary cleft lip and palate repair. Plast Reconstr Surg. 2022.
Buchman et al. Reply: Management of Calcified Cephalohematoma of Infancy: The University of Michigan 25-Year Experience. Plast Reconstr Surg. 2022.
Buchman et al. Surgical Timing and Neurocognitive Development among Patients with Craniosynostosis: Analysis of Confounders. Plast Reconstr Surg. 2023.
Buchman et al. Managing the Soft-Tissue Envelope in Facial Feminization Surgery: Filling and Tightening Surgical Approaches. Plast Reconstr Surg. 2023.
Buchman et al. Longitudinal Assessment of Neurodevelopment in Patients With Nonsyndromic Single-Suture Craniosynostosis: A Retrospective Review of 66 Patients. J Craniofac Surg. 2023.
Buchman et al. Adipose-Derived Stem Cells Enhance Graft Incorporation and Mineralization in a Murine Model of Irradiated Mandibular Nonvascularized Bone Grafting. Ann Plast Surg. 2023.
Buchman et al. H vessel formation as a marker for enhanced bone healing in irradiated distraction osteogenesis. Semin Plast Surg. 2024.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Chen et al. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovasc Drugs Ther. 2021.
Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.
Chen et al. Impact of donor blood type on outcomes after prolonged allograft ischemic times. J Thorac Cardiovasc Surg. 2022.
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen et al. Risk factors for heart transplant survival with greater than 5 h of donor heart ischemic time. J Card Surg. 2021.
Chen et al. Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31/FIH1/HIF-1α pathway. J Mol Cell Cardiol. 2022.
Chen et al. RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II. Pharmacol Res. 2022.
Chen et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. Redox Biol. 2022.
Chen et al. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. J Clin Invest. 2022.
Chen et al. Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis. Cells. 2022.
Chen et al. Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Adv Sci (Weinh). 2023.
Chen et al. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates. Cell Metab. 2023.
Chen et al. PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm. JCI Insight. 2023.
Chen et al. Circular RNA as Therapeutic Targets in Atherosclerosis: Are We Running in Circles?. J Clin Med. 2023.
Chen et al. SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies. Cells. 2024.
Chen YE et al. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration. Biomaterials. 2015.
Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.
Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.
Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.
Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.
Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Chen YE et al. Translating Cardiovascular Genomics to Clinical Practice. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Improving the genome assembly of rabbits with long-read sequencing. Genomics. 2021.
Chen YE et al. Biomimetic tubular scaffold with heparin conjugation for rapid degradation in in situ regeneration of a small diameter neoartery. Biomaterials. 2021.
Chen YE et al. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021.
Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Cohen et al. A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro. Surgery. 2021.
Cohen et al. Early biochemical response to parathyroidectomy for primary hyperparathyroidism and its predictive value for recurrent hypercalcemia and recurrent primary hyperparathyroidism. Surgery. 2021.
Cohen et al. Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics. Ann Surg. 2021.
Cohen et al. LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. Nat Cell Biol. 2021.
Cohen et al. Identification of novel lipid metabolic biomarkers associated with poor adrenocortical carcinoma prognosis using integrated bioinformatics. Surgery. 2022.
Cohen et al. Re-evaluation of combinational efficacy and synergy of the italian protocol in vitro: Are we truly optimizing benefit or permitting unwanted toxicity?. Biomedicines. 2021.
Edwards et al. Dental students’ OMFS-related experiences and interest in OMFS careers: An exploration. J Dent Educ. 2021.
Edwards et al. Squamous Cell Carcinoma of the Tongue in Young Patients: A Case Series and Literature Review. J Oral Maxillofac Surg. 2021.
Edwards et al. Comparisons of orthodontic residents’ performance and attitudes using 2D, 3D, and virtual reality surgical simulation methods. J Dent Educ. 2021.
Edwards et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Edwards et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Edwards et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Edwards et al. Clinical Practice Trends and Postoperative Outcomes in Primary Cleft Rhinoplasty. Cleft Palate Craniofac J. 2022.
Edwards et al. Resolution of mandibular fibrous dysplasia following imatinib therapy in Noonan syndrome. Pediatr Blood Cancer. 2023.
Edwards et al. Oral maxillofacial surgery resident, faculty and practitioner role models and dental students’ interest in oral maxillofacial surgery careers: Does gender matter?. J Dent Educ. 2023.
Edwards et al. Pediatric Mandibular Reconstruction. Atlas Oral Maxillofac Surg Clin North Am. 2023.
Fabiilli et al. Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber Model In Vivo. Tissue Eng Part C Methods. 2024.
Feinberg SE et al. Tissue engineering of lips and muco-cutaneous junctions: in vitro development of tissue engineered constructs of oral mucosa and skin for lip reconstruction. Tissue Eng Part C Methods. 2012.
Feinberg SE et al. Intraoral grafting of tissue-engineered human oral mucosa. Int J Oral Maxillofac Implants. 2013.
Feinberg SE et al. Fabrication of Large Size Ex Vivo-Produced Oral Mucosal Equivalents for Clinical Application. Tissue Eng Part C Methods. 2015.
Feinberg SE et al. In Vitro Development of a Mucocutaneous Junction for Lip Reconstruction. J Oral Maxillofac Surg. 2016.
Feinberg SE et al. Soft Tissue Engineering. Oral Maxillofac Surg Clin North Am. 2017.
Green et al. Tracheal agenesis: Esophageal airway support with a 3-dimensional–printed bioresorbable splint. JTCVS Tech. 2021.
Green et al. Modified Minerva Orthosis for Postoperative Management of Cricotracheal Resection in Children. Ear Nose Throat J. 2023.
Green et al. Addressing the Pandemic Training Deficiency: Filling the Void with Simulation in Facial Reconstruction. Laryngoscope. 2021.
Green et al. A national pediatric otolaryngology fellowship virtual dissection course using 3D printed simulators. Int J Pediatr Otorhinolaryngol. 2022.
Green et al. Difficult airway management in children with trisomy 18: a retrospective single-centre study of incidence, outcomes, and complications. Br J Anaesth. 2023.
Green et al. Pediatric Tracheostomy Emergency Readiness Assessment Tool: International Consensus Recommendations. Laryngoscope. 2023.
Green GE et al. Bioresorbable Airway Splint Created with a Three-Dimensional Printer. N Engl J Med. 2013.
Green GE et al. Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients. Sci Transl Med. 2015.
Green GE et al. Regulatory Considerations in the Design and Manufacturing of Implantable 3D-Printed Medical Devices. Clin Transl Sci. 2015.
Green GE et al. A 3D-printed Lateral Skull Base Implant for Repair of Tegmen Defects. Otol Neurotol. 2020.
Green GE et al. Co-culture of adipose-derived stem cells and chondrocytes on three-dimensionally printed bioscaffolds for craniofacial cartilage engineering. Laryngoscope. 2018.
Green GE et al. Modified Minerva Cervical Thoracic Orthosis for Postoperative Management of Cricotracheal Resection. Ear Nose Throat J. 2021.
Green GE et al. Competency-Based Assessment Tool for Pediatric Esophagoscopy: International Modified Delphi Consensus. Laryngoscope. 2021.
Green GE et al. Evaluating Directional Dependency of Selective Laser Sintered Patient Specific Biodegradable Devices to Improve Predictive Modeling and Design Verification. Ann Biomed Eng. 2021.
Green GE et al. Characterization of noise exposure in places of worship. Appl Acoust. 2021.
Kemp et al. Comparison of Outcomes of Spinal Accessory to Suprascapular Nerve Transfer Versus Nerve Grafting for Neonatal Brachial Plexus Injury. Orthopedics. 2022.
Kemp et al. The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals. J Vis Exp. 2022.
Kemp et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Kemp et al. “Decreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)”. Ann Vasc Surg. 2022.
Kemp et al. Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-Dimension, Cuff-Less Microneedle Electrode Array. Small. 2022.
Kemp et al. Pathophysiological and Neuroplastic Changes in Postamputation and Neuropathic Pain: Review of the Literature. Plast Reconstr Surg Glob Open. 2022.
Kemp et al. Ultrasound appearance of regenerative peripheral nerve interface with clinical correlation. Skeletal Radiol. 2023.
Kemp et al. Dermal Sensory Regenerative Peripheral Nerve Interface for Reestablishing Sensory Nerve Feedback in Peripheral Afferents in the Rat. Plast Reconstr Surg. 2023.
Kemp et al. Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes. J Neural Eng. 2023.
Kemp et al. Michigan special issue: 60 years of Michigan plastic surgery. Semin Plast Surg. 2024.
Kemp et al. Merging humans and neuroprosthetics through regenerative peripheral nerve interfaces. Semin Plast Surg. 2024.
Kemp SWP et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Kruger et al. Acupressure for cancer-fatigue in ovarian cancer survivor (The AcuOva Study): A community-based clinical trial study protocol examining the impact of self-acupressure on persistent cancer related fatigue in ovarian cancer survivors. Contemp Clin Trials. 2021.
Kruger et al. Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study. J Urol. 2022.
Kruger et al. Reply by Authors. J Urol. 2022.
Lempka et al. The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation. Neuromodulation. 2021.
Lempka et al. Quantitative Sensory Testing of Spinal Cord and Dorsal Root Ganglion Stimulation in Chronic Pain Patients. Neuromodulation. 2021.
Lempka et al. Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action. J Pain. 2022.
Lempka et al. Neural Recruitment During Conventional, Burst, and 10-kHz Spinal Cord Stimulation for Pain. J Pain. 2022.
Lempka et al. Augmented Transcutaneous Stimulation Using an Injectable Electrode: A Computational Study. Front Bioeng Biotechnol. 2021.
Lempka et al. Glossary of Neurostimulation Terminology: A Collaborative Neuromodulation Foundation, Institute of Neuromodulation, and International Neuromodulation Society Project. Neuromodulation. 2022.
Lempka et al. A systematic review of computational models for the design of spinal cord stimulation therapies: from neural circuits to patient-specific simulations. J Physiol. 2023.
Lempka et al. Modeling extracellular stimulation of retinal ganglion cells: theoretical and practical aspects. J Neural Eng. 2023.
Lempka et al. Evoked compound action potentials during spinal cord stimulation: effects of posture and pulse width on signal features and neural activation within the spinal cord. J Neural Eng. 2023.
Lempka et al. An optimization framework for targeted spinal cord stimulation. J Neural Eng. 2023.
Lempka et al. Postural Changes in Spinal Cord Stimulation Thresholds: Current and Voltage Sources. Neuromodulation. 2024.
Lempka et al. Model-based analysis of subthreshold mechanisms of spinal cord stimulation for pain. J Neural Eng. 2023.
Lempka et al. A Definition of Neuromodulation and Classification of Implantable Electrical Modulation for Chronic Pain. Neuromodulation. 2024.
Lempka et al. Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: a computational modeling study. J Neurophysiol. 2024.
Lempka et al. Does high-frequency stimulation of sensory axons break the causal link between pain relief and paresthesia?. Neuron. 2024.
Love et al. Swellable catheters based on a dynamic expanding inner diameter. J Mater Sci Mater Med. 2021.
Love et al. Development of a Microcontroller-Based, Small-Scale Rotational Fiber Collection Device. J Chem Educ. 2021.
Love et al. Informing the Public about Microplastics through a University and Museum Partnership. J Chem Educ. 2024.
Love et al. Dewatering of super absorbent polymers: Alternatives to thermal desorption by liquid phase extraction using dimethyl ether. Resour Conserv Recy. 2021.
Mehta et al. Atovaquone: An Inhibitor of Oxidative Phosphorylation as Studied in Gynecologic Cancers. Cancers (Basel). 2022.
Mehta et al. The MEK1/2 pathway as a therapeutic target in high-grade serous ovarian carcinoma. Cancers (Basel). 2021.
Mehta et al. Injectable three-dimensional tumor microenvironments to study mechanobiology in ovarian cancer. Acta Biomater. 2022.
Mehta et al. Applications of Innovation Technologies for Personalized Cancer Medicine: Stem Cells and Gene-Editing Tools. ACS Pharmacol Transl Sci. 2023.
Mehta G et al. Personalized Medicine–Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids. Clin Cancer Res. 2017.
Mehta G et al. Integrated cancer tissue engineering models for precision medicine. PLoS One. 2019.
Mehta G et al. Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance. Neoplasia. 2019.
Mehta G et al. Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments. J Immunother Cancer. 2019.
Mehta G et al. Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor. Cancers (Basel). 2020.
Mehta G et al. Personalized models of heterogeneous 3D epithelial tumor microenvironments: Ovarian cancer as a model. Acta Biomater. 2021.
Mehta G et al. Design and applications of surfaces that control the accretion of matter. Sci. 2021.
Shea et al. Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering. Lancet Diabetes Endocrinol. 2021.
Shea et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea et al. Tolerance induced by antigen-loaded plg nanoparticles affects the phenotype and trafficking of transgenic cd4+ and cd8+ t cells. Cells. 2021.
Shea et al. Mechanistic contributions of Kupffer cells and liver sinusoidal endothelial cells in nanoparticle-induced antigen-specific immune tolerance. Biomaterials. 2022.
Shea et al. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci U S A. 2022.
Shea et al. Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer. Clin Exp Metastasis. 2022.
Shea et al. Human Lung Organoid Culture in Alginate With and Without Matrigel to Model Development and Disease. Tissue Eng Part A. 2022.
Shea et al. Follicle isolation methods reveal plasticity of granulosa cell steroidogenic capacity during mouse in vitro follicle growth. Mol Hum Reprod. 2022.
Shea et al. Nanoparticle dose and antigen loading attenuate antigen-specific T-cell responses. Biotechnol Bioeng. 2023.
Shea et al. Membrane-coated nanoparticles for direct recognition by T cells. Biotechnol Bioeng. 2023.
Shea et al. Biodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury. Pain. 2024.
Shea LD et al. Microporous scaffolds support assembly and differentiation of pancreatic progenitors into ß-cell clusters. Acta Biomater. 2019.
Shea LD et al. Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2019.
Shea LD et al. Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes. Cancer Res. 2020.
Shea LD et al. Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. Tissue Eng Part A. 2020.
Shea LD et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea LD et al. An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides. J Control Release. 2021.
Shea LD et al. Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials. 2021.
Shea LD et al. Cargo-free immunomodulatory nanoparticles combined with anti-PD-1 antibody for treating metastatic breast cancer. Biomaterials. 2021.
Shea LD et al. IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury. Biotechnol Bioeng. 2021.
Shikanov A et al. Synthetic hydrogel supports the function and regeneration of artificial ovarian tissue in mice. NPJ Regen Med. 2016.
Shikanov A et al. Adipose-derived stem cell-secreted promote survival, growth and maturation of early-stage murine follicles. Stem Cell Res Ther. 2019.
Shikanov A et al. A mouse model to investigate the impact of testosterone therapy on reproduction in transgender men. Hum Reprod. 2019.
Shikanov A et al. Encapsulation of ovarian allograft precludes immune rejection and promotes restoration of endocrine function in immune-competent ovariectomized mice. Sci Rep. 2019.
Shikanov A et al. Synergy of Paracrine Signaling During Early-Stage Mouse Ovarian Follicle Development In Vitro. Cell Mol Bioeng. 2018.
Shikanov A et al. A View from the past into our collective future: the oncofertility consortium vision statement. J Assist Reprod Genet. 2021.
Shikanov A et al. Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation. Acta Biomater. 2021.
Shikanov A et al. Swellable catheters based on a dynamic expanding inner diameter. J Mater Sci Mater Med. 2021.
Shikanov A et al. TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells. JCI Insight. 2021.
Shikanov et al. Physical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels. Adv Funct Mater. 2022.
Shikanov et al. Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq. Dev Cell. 2022.
Shikanov et al. Pharmacokinetic comparison of three delivery systems for subcutaneous testosterone administration in female mice. Gen Comp Endocrinol. 2022.
Shikanov et al. Single-cell RNA-sequencing of retrieved human oocytes and eggs in clinical practice and for human ovarian cell atlasing. Mol Reprod Dev. 2022.
Shikanov et al. A mouse model mimicking gender-affirming treatment with pubertal suppression followed by testosterone in transmasculine youth. Hum Reprod. 2023.
Shikanov et al. Presence of ovarian stromal aberrations after cessation of testosterone therapy in a transgender mouse model†. Biol Reprod. 2023.
Shikanov et al. Effect of Donor Age on Endocrine Function of and Immune Response to Ovarian Grafts. Int J Mol Sci. 2024.
Shikanov et la. Impaired in vitro fertilization outcomes following testosterone treatment improve with washout in a mouse model of gender-affirming hormone treatment. Am J Obstet Gynecol. 2023.
Shtein et al. Kirigami-Based Compliant Mechanism for Multiaxis Optical Tracking and Energy-Harvesting Applications. Adv Eng Mat. 2021.
Shtein M et al. Developable Rotationally Symmetric Kirigami-Based Structures as Sensor Platforms. Adv Mater. 2019.
Shtein M et al. Dynamic kirigami structures for integrated solar tracking. Nat Comm. 2017.
Shtein M et al. Printing of small molecular medicines from the vapor phase. Nat Comm. 2017.
Shtein M et al. An electric-eel-inspired soft power source from stacked hydrogels. Nature. 2017.
Shtein M et al. Chemical Vapor Jet Deposition of Parylene Polymer Films in Air. Macromolecules. 2015.
Stegeman et al. Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method. Semin Thromb Hemost. 2023.
Stegemann et al. Aseptic and septic prosthetic joint loosening: Impact of biomaterial wear on immune cell function, inflammation, and infection. Biomaterials. 2021.
Stegemann et al. Controlled growth factor delivery and cyclic stretch induces a smooth muscle cell-like phenotype in adipose-derived stem cells. Cells. 2021.
Stegemann et al. Fabrication and characterization of osteogenic function of progenitor cell-laden gelatin microcarriers. J Biomed Mater Res B Appl Biomater. 2022.
Stegemann et al. Multimodular vascularized bone construct comprised of vasculogenic and osteogenic microtissues. Biotechnol Bioeng. 2022.
Stegemann et al. A combination of matrix stiffness and degradability dictate microvascular network assembly and remodeling in cell-laden poly(ethylene glycol) hydrogels. Biomaterials. 2023.
Stegemann et al. The Year 2022 in biomaterials research: A perspective from the editors of six leading journals. J Biomed Mater Res A. 2023.
Stegemann et al. Crossover of surface waves and capillary-viscous-elastic transition in soft biomaterials detected by resonant acoustic rheometry. Biomaterials. 2023.
Stegemann JP et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
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