Developmental Biology
Developmental biology research seeks to understand the mechanisms by which an organism develops in a concerted manner. This information can be utilized to design interventions to support regeneration and restoration of tissues.
Researchers
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Mohammed AkaabouneLSA -
Benjamin AllenMedicine -
Steven BuchmanMedicine -
Laura ButtittaLSA -
Sally CamperMedicine -
Greg ClinesMedicine -
Rhima ColemanEngineering -
Catherine CollinsLSA -
Gregory DresslerMedicine -
Cunming DuanLSA -
Renny FranceschiDentistry -
Jianping FuEngineering -
Katherine GallagherMedicine -
Roman GigerMedicine -
Dan GoldmanMedicine -
Gary HammerMedicine -
Sue HammoudMedicine -
Kurt HankensonMedicine -
Jennifer HarderMedicine -
Nan HatchDentistry -
Idse HeemskerkMedicine -
Todd HerronMedicine -
Peter HitchcockMedicine -
Lori IsomMedicine -
Shigeki IwaseMedicine -
Evan KellerMedicine -
Megan KillianMedicine -
Matthias KretzlerMedicine -
Liu LiuMedicine -
Isabelle LombaertDentistry -
Yuji MishinaDentistry -
Jack ParentMedicine -
Antonia PopovaMedicine -
Rajesh RaoMedicine -
Liangyou RuiMedicine -
Gary D. SmithMedicine -
Jason SpenceMedicine -
Tomer SternDentistry -
Lauren SurfaceDentistry -
Zhong WangMedicine
Select Publications
Akaaboune et al. Distinct roles of the dystrophin-glycoprotein complex: α-dystrobrevin and α-syntrophin in the maintenance of the postsynaptic apparatus of the neuromuscular synapse. Hum Mol Genet. 2022.
Akaaboune M et al. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science. 1999.
Akaaboune M et al. Neurotransmitter Receptor Dynamics Studied in vivo by Reversible Photo-Unbinding of Fluorescent Ligands. Neuron. 2002.
Akaaboune M et al. Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin. J Cell Biol. 2011.
Akaaboune M et al. AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic Membrane of NMJs in Living Mice. J Neurosci. 2016.
Akaaboune M et al. The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice. Mol Metab. 2020.
Allen BL et al. Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 2014.
Allen BL et al. Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Biol Chem. 2015.
Allen BL et al. Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif. J Biol Chem. 2017.
Allen BL et al. Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib. Proc Natl Acad Sci U S A. 2017.
Allen BL et al. The Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. Development. 2020.
Allen BL et al. Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer. Clin Cancer Res. 2021.
Allen et al. Unique lingual expression of the Hedgehog pathway antagonist Hedgehog-interacting protein in filiform papillae during homeostasis and ectopic expression in fungiform papillae during Hedgehog signaling inhibition. Dev Dyn. 2022.
Allen et al. C-X-C motif chemokine ligand 1 induced by Hedgehog signaling promotes mouse extrahepatic bile duct repair after acute injury. Hepatology. 2022.
Allen et al. Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer. PLoS Genet. 2022.
Allen et al. CDON contributes to Hedgehog-dependent patterning and growth of the developing limb. Dev Biol. 2023.
Allen et al. Developing Future Biologists: developmental biology for undergraduates from underserved communities. Development. 2023.
Allen et al. Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis. PLoS One. 2024.
Allen et al. Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth. Cancer Discov. 2024.
Allen et al.Pancreatic Fibroblast Heterogeneity: From Development to Cancer. Cells. 2020
Buchman et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Buchman et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Buchman et al. Institutional trends in opioid prescribing and utilization after primary cleft lip and palate repair. Plast Reconstr Surg. 2022.
Buchman et al. Reply: Management of Calcified Cephalohematoma of Infancy: The University of Michigan 25-Year Experience. Plast Reconstr Surg. 2022.
Buchman et al. Surgical Timing and Neurocognitive Development among Patients with Craniosynostosis: Analysis of Confounders. Plast Reconstr Surg. 2023.
Buchman et al. Managing the Soft-Tissue Envelope in Facial Feminization Surgery: Filling and Tightening Surgical Approaches. Plast Reconstr Surg. 2023.
Buchman et al. Longitudinal Assessment of Neurodevelopment in Patients With Nonsyndromic Single-Suture Craniosynostosis: A Retrospective Review of 66 Patients. J Craniofac Surg. 2023.
Buchman et al. Adipose-Derived Stem Cells Enhance Graft Incorporation and Mineralization in a Murine Model of Irradiated Mandibular Nonvascularized Bone Grafting. Ann Plast Surg. 2023.
Buchman et al. Reasons for Removal of Rigid Internal Fixation Devices in Craniofacial Surgery: A 20-year Update. J Craniofac Surg. 2024.
Buchman et al. H vessel formation as a marker for enhanced bone healing in irradiated distraction osteogenesis. Semin Plast Surg. 2024.
Buchman et al. Low Prevalence of Clinically Significant Hyponatremia following Cranial Vault Reconstruction for Single-Suture Craniosynostosis. Plast Reconstr Surg. 2024.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Buttitta et al. Monitoring Spontaneous Quiescence and Asynchronous Proliferation-Quiescence Decisions in Prostate Cancer Cells. Front Cell Dev Biol. 2021.
Buttitta et al. Developing Future Biologists: developmental biology for undergraduates from underserved communities. Development. 2023.
Buttitta et al. HER2 as a potential therapeutic target on quiescent prostate cancer cells. Transl Oncol. 2023.
Buttitta et al. Transcriptional repression and enhancer decommissioning silence cell cycle genes in postmitotic tissues. G3 (Bethesda). 2024.
Buttitta LA et al. Protein Phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015.
Buttitta LA et al. Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Biol Open. 2016.
Buttitta LA et al. Chromatin organization changes during the establishment and maintenance of the postmitotic state. Epigenetics Chromatin. 2017.
Buttitta LA et al. Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells. PLoS Biol. 2019.
Buttitta LA et al. Polyploidy in the adult Drosophila brain. Elife. 2020.
Buttitta LA et al. Abscisic acid regulates dormancy of prostate cancer disseminated tumor cells in the bone marrow. Neoplasia. 2021.
Buttitta LA et al. The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1. Proc Natl Acad Sci U S A. 2021.
Camper et al. Comprehensive Identification of Pathogenic Gene Variants in Patients With Neuroendocrine Disorders. J Clin Endocrinol Metab. 2021.
Camper et al. The phenotypic spectrum associated with OTX2 mutations in humans. Eur J Endocrinol. 2021.
Camper et al. Novel mechanism of pituitary hormone deficiency: genetic variants shift splicing to produce a dominant negative transcription factor isoform. Eur J Endocrinol. 2021.
Camper et al. Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. Hum Mol Genet. 2023.
Camper et al. Novel genes and variants associated with congenital pituitary hormone deficiency in the era of next-generation sequencing. Front Endocrinol (Lausanne). 2022.
Camper et al. Disruption of RNA Splicing Is an Important Contributor to Congenital Hypopituitarism and Other Human Genetic Diseases. Endocrinology. 2023.
Camper et al. Pituitary stem cells: past, present and future perspectives. Nat Rev Endocrinol. 2024.
Camper SA et al. Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era. Endocr Rev. 2016.
Camper SA et al. Next generation sequencing panel based on single molecule molecular inversion probes for detecting genetic variants in children with hypopituitarism. Mol Genet Genomic Med. 2018.
Camper SA et al. PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression. Endocrinology. 2020.
Camper SA et al. Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease. Hum Mol Genet. 2020.
Camper SA et al. Rathke’s cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors. J Clin Invest. 2020.
Camper SA et al. Pituitary Tumors and Immortalized Cell Lines Generated by Cre-Inducible Expression of SV40 T Antigen. Endocrinology. 2021.
Camper SA et al. High-throughput splicing assays identify missense and silent splice-disruptive POU1F1 variants underlying pituitary hormone deficiency. Am J Hum Genet. 2021.
Clines et al. Osteoblasts Generate Testosterone From DHEA and Activate Androgen Signaling in Prostate Cancer Cells. J Bone Miner Res. 2021.
Clines et al. Clinical bone health among adults with cerebral palsy: moving beyond assessing bone mineral density alone. Dev Med Child Neurol. 2022.
Clines et al. Ca2+-independent phospholipase A2β-derived PGE2 contributes to osteogenesis. Prostaglandins Other Lipid Mediat. 2022.
Clines et al. Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2023.
Clines et al. Perspective: A multi-trait integrative approach to understanding the structural basis of bone fragility for pediatric conditions associated with abnormal bone development. Bone. 2023.
Clines GA et al. Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor. J Bone Miner Res. 2011.
Clines GA et al. Dural Cells Release Factors Which Promote Cancer Cell Malignancy and Induce Immunosuppressive Markers in Bone Marrow Myeloid Cells. Neurosurgery. 2018.
Clines GA et al. DKK1 and Kremen Expression Predicts the Osteoblastic Response to Bone Metastasis. Transl Oncol. 2018.
Clines GA et al. The challenges of diagnosing osteoporosis and the limitations of currently available tools. Clin Diabetes Endocrinol. 2018.
Clines GA et al. Castration Determines the Efficacy of ETAR Blockade in a Mouse Model of Prostate Cancer Bone Metastasis. Endocrinology. 2019.
Coleman et al. Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies. Curr Rheumatol Rep. 2022.
Coleman et al. Cartilage thickness mismatches in patellar osteochondral allograft transplants affect local cartilage stresses. J Orthop Res. 2023.
Coleman et al. Osteoporosis GWAS-implicated DNM3 locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels. JBMR Plus. 2024.
Collins CA et al. Mitochondrial fission, integrity and clearance require separable functions of Vps13D in Drosophila neurons. bioRxiv. 2020.
Collins CA et al. Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J Cell Biol. 2010.
Collins CA et al. The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol. 2012.
Collins CA et al. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. eLife. 2016.
Collins CA et al. Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104. Elife. 2017.
Collins CA et al. Regulation of longevity by depolarization-induced activation of PLC-β-IP 3 R signaling in neurons. Proc Natl Acad Sci U S A. 2021.
Collins CA et al. An NAD+/NMN balancing act by SARM1 and NMNAT2 controls axonal degeneration. J Neuron. 2021.
Collins et al. DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses. Cell Rep. 2024.
Dressler et al. Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021.
Dressler et al. Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation. Cell Chem Biol. 2022.
Dressler et al. Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease. Kidney Int. 2024.
Dressler et al. Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury. Am J Physiol Renal Physiol. 2024.
Duan C et al. Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc Natl Acad Sci U S A. 2010.
Duan C et al. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 2014.
Duan C et al. Ca2+ concentration-dependent premature death of igfbp5a mutant zebrafish reveals a critical role of IGF signaling in adaptive epithelial growth. Sci Signal. 2018.
Duan C et al. Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. Elife. 2019.
Duan C et al. The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. Elife. 2020.
Duan et al. Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Front Cell Dev Biol. 2021.
Duan et al. IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. Gen Comp Endocrinol. 2021.
Duan et al. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Proc Natl Acad Sci U S A. 2023.
Feldman et al. High-Intensity Interval Training, Caloric Restriction, or Their Combination Have Beneficial Effects on Metabolically Acquired Peripheral Neuropathy. Diabetes. 2024.
Franceschi et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.
Franceschi et al. Role of Runx2 in prostate development and stem cell function. Prostate. 2021.
Franceschi et al. Role of Discoidin Domain Receptor 2 in Craniofacial Bone Regeneration. J Dent Res. 2021.
Franceschi et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Franceschi et al. Expression of Beta-Catenin, Cadherins and P-Runx2 in Fibro-Osseous Lesions of the Jaw: Tissue Microarray Study. Biomolecules. 2022.
Franceschi et al. Cranial Base Synchondrosis: Chondrocytes at the Hub. Int J Mol Sci. 2022.
Franceschi et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022.
Franceschi et al. Control of Craniofacial Development by the Collagen Receptor, Discoidin Domain Receptor 2. Elife. 2023.
Franceschi et al. Acoustic droplet vaporization for on-demand modulation of microporosity in smart hydrogels. Acta Biomater. 2023.
Franceschi et al. Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells. Acta Biomater. 2023.
Franceschi et al. Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis. J Pathol. 2024.
Franceschi RT et al. Advanced BMP gene therapies for temporal and spatial control of bone regeneration. J Dent Res. 2013.
Franceschi RT et al. Discoidin Domain Receptor 2 Controls Bone Formation and Marrow Adipogenesis. J Bone Miner Res. 2016.
Franceschi RT et al. Control of the osteoblast lineage by mitogen-activated protein kinase signaling. Curr Mol Biol Rep. 2017.
Franceschi RT et al. Selective Role of Discoidin Domain Receptor 2 in Murine Temporomandibular Joint Development and Aging. J Dent Res. 2018.
Franceschi RT et al. Genetic inhibition of PPAR-gamma S112 phosphorylation reduces bone formation and stimulates marrow adipogenesis. Bone. 2018.
Franceschi RT et al. Patient perceptions of SARS-CoV-2 exposure risk and association with continuity of ophthalmic care. JAMA Opthalmol. 2021.
Franceschi RT et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.
Fu et al. Branching development of early post-implantation human embryonic-like tissues in 3D stem cell culture. Biomaterials. 2021.
Fu et al. Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation. Nano Today. 2021.
Fu et al. Elucidating the behavior of trophectoderm derivatives in mouse implantation. Dev Cell. 2022.
Fu et al. Engineering multiscale structural orders for high-fidelity embryoids and organoids. Cell Stem Cell. 2022.
Fu et al. In vitro germ cell induction from fertile and infertile monozygotic twin research participants. Cell Rep Med. 2022.
Fu et al. Modeling development using microfluidics: bridging gaps to foster fundamental and translational research. Curr Opin Genet Dev. 2023.
Fu et al. Why researchers should use human embryo models with caution. Nature. 2023.
Fu et al. A Definition of Neuromodulation and Classification of Implantable Electrical Modulation for Chronic Pain. Neuromodulation. 2024.
Fu et al. Changing the public perception of human embryology. Nat Cell Bio. 2023.
Fu et al. The role of copy number variants in the genetic architecture of common familial epilepsies. Epilepsia. 2024.
Fu et al. A patterned human neural tube model using microfluidic gradients. Nature. 2024.
Fu et al. Metabolic-Glycoengineering-Enabled Molecularly Specific Acoustic Tweezing Cytometry for Targeted Mechanical Stimulation of Cell Surface Sialoglycans. Angew Chem Int Ed Engl. 2024.
Fu et al. Toward developing human organs via embryo models and chimeras. Cell. 2024.
Fu et al. Criteria for the standardization of stem-cell-based embryo models. Nat Cell Biol. 2024.
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Fu J et al. Stem-cell-based embryo models for fundamental research and translation. Nat Mater. 2021.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Giger et al. DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses. Cell Rep. 2024.
Giger et al. Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration. Cell Rep. 2024.
Giger RJ et al. Neuroinflammation triggered by ß-glucan/dectin-1 signaling enables CNS axon regeneration. Proc Natl Acad Sci U S A. 2015.
Giger RJ et al. A new neutrophil subset promotes CNS neuron survival and axon regeneration. Nat Immunol. 2020.
Giger RJ et al. THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes. Proc Natl Acad Sci USA. 2021.
Giger RJ et al. Analysis of the immune response to sciatic nerve injury identified efferocytosis as a key mechanism of nerve debridement. bioRxiv. 2020.
Goldman D et al. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci. 2006.
Goldman D et al. Ascl1a regulates Müller glia dedifferentiation and retina regeneration via a Lin-28-dependent, let-7 miRNA signaling pathway. Nat Cell Biol. 2010.
Goldman D et al. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012.
Goldman D et al. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Proc Natl Acad Sci U S A. 2013.
Goldman D et al. Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. Elife. 2020.
Goldman et al. Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury. Glia. 2021.
Goldman et al. Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proc Natl Acad Sci U S A. 2022.
Goldman et al. Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 2023.
Goldman et al. Parathyroid hormone and trabectedin have differing effects on macrophages and stress fracture repair. Bone. 2024.
Goldman et al. Giant magnetocaloric effect in spin supersolid candidate Na2BaCo(PO4)2. Nature. 2024.
Hammer et al. American Association of Endocrine Surgeons Guidelines for Adrenalectomy: Executive Summary. JAMA Surg. 2022.
Hammer et al. Targeting of a New Node in Lipid Metabolism as a Potential Treatment Strategy for ACC. Endocrinology. 2023.
Hammer et al. β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer. Cancer Res. 2023.
Hammer et al. Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner. Nat Aging. 2023.
Hammer et al. Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism. Mol Cell Endocrinol. 2024.
Hammer GD et al. Mouse models of adrenocortical tumors. Mol Cell Endocrinol. 2016.
Hammer GD et al. 5th International ACC Symposium: Introduction. Horm Cancer. 2016.
Hammer GD et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016.
Hammer GD et al. Molecular Heterogeneity in Aldosterone-Producing Adenomas. J Clin Endocrinol Metab. 2016.
Hammer GD et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016.
Hammer GD et al. Stem cell function and plasticity in the normal physiology of the adrenal cortex. Mol Cell Endocrinol. 2021.
Hammer GD et al. β-catenin in adrenal zonation and disease. Mol Cell Endocrinol. 2021.
Hammer GD et al. What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics. Endocr Pathol. 2021.
Hammoud et al. Regulation of meiotic progression by Sertoli-cell androgen signaling. Mol Biol Cell. 2020.
Hammoud et al. TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Nat Commun. 2021.
Hammoud et al. The solute carrier family 7 member 11 (SLC7A11) is regulated by LH/androgen and required for cystine/glutathione homeostasis in mouse Sertoli cells. Mol Cell Endocrinol. 2022.
Hammoud et al. Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germline cells. J Mol Cell Cardiol. 2023.
Hammoud et al. Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1. Nat Struct Mol Biol. 2023.
Hammoud et al. Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility. F S Sci. 2024.
Hammoud et al. Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women. Proc Natl Acad Sci U S A 2024.
Hankenson et al. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts. Bone. 2021.
Hankenson et al. Constitutive bone marrow adipocytes suppress local bone formation. JCI Insight. 2022.
Hankenson et al. Stereochemistry Determines Immune Cellular Responses to Polylactide Implants. ACS Biomater Sci Eng. 2023.
Hankenson et al. The multifaceted role of mast cells in joint inflammation and arthritis. Osteoarthritis Cartilage. 2023.
Hankenson et al. Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing. Bone. 2023.
Hankenson et al. Comparison of true blood loss between short and long cephalomedullary nail fixation of geriatric hip fractures, a retrospective cohort study. Eur J Orthop Surg Traumatol. 2023.
Hankenson et al. Thrombospondins modulate cell function and tissue structure in the skeleton. Semin Cell Dev Biol. 2024.
Hankenson et al. Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming. Adv Sci (Weinh). 2023.
Hankenson et al. Silver-releasing bioactive glass nanoparticles for infected tissue regeneration. Biomater Adv. 2023.
Hankenson et al. Tailored Coatings for Enhanced Performance of Zinc-Magnesium Alloys in Absorbable Implants. ACS Biomater Sci Eng. 2024.
Hankenson et al. Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements. EBioMedicine. 2024.
Hankenson et al. Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism. Bioact Mater. 2024.
Hankenson et al. Signaling pathways associated with Lgr6 to regulate osteogenesis. Bone. 2024.
Hankenson et al. Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials. Nat Biomed Eng. 2024.
Hankenson KD et al. Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regen Med. 2017.
Hankenson KD et al. R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Bone Res. 2018.
Hankenson KD et al. Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density. Nat Commun. 2019.
Hankenson KD et al. CTRP3 Regulates Endochondral Ossification and Bone Remodeling During Fracture Healing. J Orthop Res. 2020.
Hankenson KD et al. Thrombospondin-2 spatiotemporal expression in skeletal fractures. J Orthop Res. 2021.
Hankenson KD et al. Canonical Notch signaling is required for bone morphogenetic protein-mediated human osteoblast differentiation. Stem Cells. 2020.
Hankenson KD et al. Biological constraints on gwas snps at suggestive significance thresholds reveal additional bmi loci. Elife. 2021.
Hankenson KD et al. Silver-doped bioactive glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant Staphylococcus aureus (MRSA) inhibition. Mater Sci Eng C Mater Biol Appl. 2021.
Hankenson KD et al. CRISPR-Cas9–Mediated Genome Editing Confirms EPDR1 as an Effector Gene at the BMD GWAS-Implicated ‘STARD3NL’ Locus. JBMR Plus. 2021.
Hankerson et al. Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma. Ann Surg. 2023.
Harder et al. Molecular programs associated with glomerular hyperfiltration in early diabetic kidney disease. Kidney Int. 2022.
Harder et al. ARF6 is a host factor for SARS-CoV-2 infection in vitro. J Gen Virol. 2023.
Harder et al. Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease. Cell Rep. 2024.
Harder JL et al. High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Cell Stem Cell. 2018.
Harder JL et al. Organoid single cell profiling identifies a transcriptional signature of glomerular disease. JCI Insight. 2020.
Harder JL et al. Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker. JCI Insight. 2020.
Harder JL et al. SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease. Kidney Int. 2020.
Hatch et al. IGF-1 TMJ injections enhance mandibular growth and bone quality in juvenile rats. Orthod Craniofac Res. 2022.
Hatch et al. Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses. Bone. 2021.
Hatch et al. Anabolic actions of parathyroid hormone in a hypophosphatasia mouse model. Osteoporos Int. 2022.
Hatch et al. Commensal Microbiota Effects on Craniofacial Skeletal Growth and Morphology. JBMR Plus. 2023.
Hatch et al. Tissue nonspecific alkaline phosphatase deficiency impairs Purkinje cell development and survival in a mouse model of infantile hypophosphatasia. Neuroscience. 2024.
Hatch et al. Control of Orthodontic Tooth Movement by Nitric Oxide Releasing Nanoparticles in Sprague-Dawley Rats. Front Mater. 2022.
Hatch NE et al. Tissue-nonspecific Alkaline Phosphatase Deficiency Causes Abnormal Craniofacial Bone Development in the Alpl-/- Mouse Model of Infantile Hypophosphatasia. Bone. 2014.
Hatch NE et al. Microsphere controlled drug delivery for local control of tooth movement. Eur J Orthod. 2019.
Hatch NE et al. Tissue nonspecific alkaline phosphatase promotes calvarial progenitor cell cycle progression and cytokinesis via Erk1,2. Bone. 2019.
Hatch NE et al. Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2C342Y/+ mouse models of Crouzon syndrome. PLoS One. 2020.
Hatch NE et al. Genetic background dependent modifiers of craniosynostosis severity. J Struct Biol. 2020.
Hatch NE et al. Tissue nonspecific alkaline phosphatase function in bone and muscle progenitor cells: Control of mitochondrial respiration and ATP production. Int J Mol Sci. 2021.
Hatch NE et al. Macropore design of tissue engineering scaffolds regulates mesenchymal stem cell differentiation fate. Biomaterials. 2021.
Heemskerk et al. Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types. Development. 2022.
Heemskerk I Full of potential: Pluripotent stem cells for the systems biology of embryonic patterning. Dev Biol. 2020.
Heemskerk I et al. Tissue cartography: compressing bio-image data by dimensional reduction. Nat Methods. 2015.
Heemskerk I et al. Differential growth triggers mechanical feedback that elevates Hippo signaling. Proc Natl Acad Sci U S A. 2016.
Heemskerk I et al. Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells. Elife. 2019.
Heemskerk I et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Phys Biol. 2021.
Heemskert et al. The many dimensions of germline competence. Curr Opin Cell Biol. 2023.
Heemskert et al. Mapping morphogenesis and mechanics in embryo models. Nat Methods. 2023.
Herron et al. Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes. Sci Rep. 2020.
Herron et al. High-throughput longitudinal electrophysiology screening of mature chamber-specific hiPSC-CMs using optical mapping. iScience. 2023.
Herron et al. Bipolar Patient–Specific In Vitro Diagnostic Test Reveals Underlying Cardiac Arrhythmia Phenotype Caused by Calcium Channel Genetic Risk Factor. Biol Psychiatry Glob Open Sci. 2024.
Herron TJ Stiffness triggers non-coding RNA pathology. Nat Biomed Eng. 2019.
Herron TJ et al. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes. J Mol Cell Cardiol. 2016.
Herron TJ et al. hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen. Sci Rep. 2017.
Herron TJ et al. Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors. Nat Commun. 2019.
Herron TJ et al. Detection of Drug-Induced Torsades de Pointes Arrhythmia Mechanisms Using hiPSC-CM Syncytial Monolayers in a High-Throughput Screening Voltage Sensitive Dye Assay. Toxicol Sci. 2020.
Hitchcock et al. Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Mol Neurobiol. 2022.
Hitchcock et al. Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina. Nat Commun. 2023.
Hitchcock PF et al. The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling. Invest Ophthalmol Vis Sci. 2015.
Hitchcock PF et al. The MicroRNA, miR-18a, Regulates NeuroD and Photoreceptor Differentiation in the Retina of Zebrafish. Dev Neurobiol. 2019.
Hitchcock PF et al. Midkine-a Is Required for Cell Cycle Progression of Müller Glia during Neuronal Regeneration in the Vertebrate Retina. J Neurosci. 2020.
Hitchcock PF et al. Inflammation and matrix metalloproteinase 9 (Mmp-9) regulate photoreceptor regeneration in adult zebrafish. Glia. 2020.
Hitchcock PF et al. Reprogramming Mller Glia to Regenerate Retinal Neurons. Annu Rev Vis Sci. 2020.
Isom et al. Gastrointestinal Symptoms and Channelopathy-Associated Epilepsy. J Pediatr. 2021.
Isom et al. Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits. JCI Insight 2021.
Isom et al. Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress. Epilepsia. 2022.
Isom et al. Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit. J Biol Chem. 2022.
Isom et al. Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules. Pharmacol Rev. 2022.
Isom et al. DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models. PLoS Biol. 2023.
Isom et al. Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model. Brain. 2024.
Isom et al. Deriving early single-rosette brain organoids from human pluripotent stem cells. Stem Cell Reports. 2023.
Isom et al. William Albert Catterall (1946-2024). Nat Neurosci. 2024.
Isom et al.Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry. 2020
Isom et al.Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Ann Clin Transl Neurol. 2020
Isom LL et al. SCN1B-linked early infantile developmental and epileptic encephalopathy. Ann Clin Transl Neurol. 2019.
Isom LL et al. Voltage-gated sodium channel ß1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. J Biol Chem. 2020.
Isom LL et al. Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Sci Transl Med. 2020.
Isom LL et al. Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons. Brain. 2020.
Isom LL et al. Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Ann Clin Transl Neurol. 2020.
Iwase et al. Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nat Commun. 2022.
Iwase et al. Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation. Commun Biol. 2020.
Iwase et al. Soma-to-germline transformation in chromatin-linked neurodevelopmental disorders?. FEBS J. 2022.
Iwase et al. Sexually Dimorphic Alterations in the Transcriptome and Behavior with Loss of Histone Demethylase KDM5C. Cells. 2023.
Iwase et al. Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression. Biochem Soc Trans. 2023.
Iwase et al. Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity. J Cell Biol. 2023.
Iwase et al. Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A, prevents excessive synaptogenesis. J Biol Chem. 2024.
Iwase et al. Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis. JCI Insights. 2024.
Iwase et al.X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. J Clin Inveset. 2020
Iwase S et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylase. Cell. 2007.
Iwase S et al. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol. 2011.
Iwase S et al. Sequencing of first-strand cDNA library reveals full-length transcriptomes. Nat Commun. 2015.
Iwase S et al. RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling. Cell Rep. 2020.
Killian et al. Overload in a Rat In Vivo Model of Synergist Ablation Induces Tendon Multiscale Structural and Functional Degeneration. J Biomech Eng. 2023.
Killian et al. Physical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels. Adv Funct Mater. 2022.
Killian et al. Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments. Dev Dyn.
Killian et al. Growth and mechanobiology of the tendon-bone enthesis. Semin Cell Dev Biol. 2022.
Killian et al. Maize brace root mechanics vary by whorl, genotype and reproductive stage. Ann Bot. 2022.
Killian et al. Targeted deletion of Fgf9 in tendon disrupts mineralization of the developing enthesis. FASEB J. 2023.
Killian et al. Overload in a Rat In Vivo Model of Synergist Ablation Induces Tendon Multiscale Structural and Functional Degeneration. J Biomech Eng. 2023.
Killian et al. Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death. Dev Dyn. 2023.
Killian et al. Equitable hiring strategies towards a diversified faculty. Nat Biomed Eng. 2023.
Killian et al. Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle. FASEB J. 2024.
Killian et al. Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice. Sci Adv. 2023.
Killian ML et al. Effects of imbalanced muscle loading on hip joint development and maturation. J Orthop Res. 2017.
Killian ML et al. Partial-width injuries of the rat rotator cuff heal with fibrosis. Connect Tissue Res. 2018.
Killian ML et al. Novel model for the induction of postnatal murine hip deformity. J Orthop Res. 2019.
Killian ML et al. Photobiomodulation does not influence maturation and mildly improves functional healing of mouse achilles tendons. J Orthop Res. 2020.
Killian ML et al. Optogenetic activation of muscle contraction in vivo. Connect Tissue Res. 2020.
Killian ML et al. Optogenetic activation of muscle contraction in vivo. Connect Tissue Res. 2021.
Kretzler et al Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease. Diabetologia. 2022.
Kretzler et al. The clinical application of urine soluble CD163 in ANCA-associated vasculitis. J Am Soc Nephrol. 2021.
Kretzler et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat Commun. 2020.
Kretzler et al. A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. Physiol Genomics. 2021.
Kretzler et al. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Lab Invest. 2021.
Kretzler et al. Nephrotic syndrome disease activity is proportional to its associated hypercoagulopathy. Thromb Res. 2021.
Kretzler et al. Rationale and design of the Kidney Precision Medicine Project. Kidney Int. 2021.
Kretzler et al. Patient perspectives and involvement in precision medicine research. Kidney Int. 2021.
Kretzler et al. Innovating and invigorating the clinical trial infrastructure for glomerular diseases. Kidney Int. 2021.
Kretzler et al. APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis. Pediatr Nephrol. 2021.
Kretzler et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 2021.
Kretzler et al. IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes. Diabetologia. 2021.
Kretzler et al. Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice. Clin Sci (Lond). 2021.
Kretzler et al. Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021.
Kretzler et al. Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building Meeting. Front Pharmacol. 2021.
Kretzler et al. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis. Kidney Int. 2021.
Kretzler et al. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. J Clin Invest. 2021.
Kretzler et al. Comprehensive search for novel circulating mirnas and axon guidance pathway proteins associated with risk of eskd in diabetes. J Am Soc Nephrol. 2021.
Kretzler et al. Renin-angiotensin system inhibition reverses the altered triacylglycerol metabolic network in diabetic kidney disease. Metabolomics. 2021.
Kretzler et al. Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy. JCI Insight. 2021.
Kretzler et al. Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes. Am J Kidney Dis. 2022.
Kretzler et al. Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney. Am J Transplant. 2022.
Kretzler et al. Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome. Am J Kidney Dis. 2022.
Kretzler et al. A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project. Am J Kidney Dis. 2022.
Kretzler et al. A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis. Kidney Int. 2022.
Kretzler et al. Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants. Kidney Int. 2022.
Kretzler et al. Unsupervised machine learning for identifying important visual features through bag-of-words using histopathology data from chronic kidney disease. Sci Rep. 2022.
Kretzler et al. Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation. Kidney Int. 2022.
Kretzler et al. Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes. Diabetes Care. 2022.
Kretzler et al. Micro-dissection and integration of long and short reads to create a robust catalog of kidney compartment-specific isoforms. PLoS Comput Biol. 2022.
Kretzler et al. Molecular Characterization of Membranous Nephropathy. J Am Soc Nephrol. 2022.
Kretzler et al. Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis. J Am Soc Nephrol. 2022.
Kretzler et al. A reference tissue atlas for the human kidney. Sci Adv. 2022.
Kretzler et al. The Michigan O’Brien Kidney Research Center: transforming translational kidney research through systems biology. Am J Physiol Renal Physiol. 2022.
Kretzler et al. Molecular programs associated with glomerular hyperfiltration in early diabetic kidney disease. Kidney Int. 2022.
Kretzler et al. Authors’ Reply: In Silico–Based Approach to the Discovery of New Antigens in Membranous Nephropathy. J Am Soc Nephrol. 2022.
Kretzler et al. Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease. Am J Kidney Dis. 2023.
Kretzler et al. Activation of Stimulator of IFN Genes (STING) Causes Proteinuria and Contributes to Glomerular Diseases. J Am Soc Nephrol. 2022.
Kretzler et al. Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease. Diabetes. 2022.
Kretzler et al. Viral associations with kidney disease diagnosis and altered kidney metatranscriptome by kidney function. Kidney Int. 2023.
Kretzler et al. Present and future directions in diabetic kidney disease. J Diabetes Complications. 2022.
Kretzler et al. Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis. Kidney Int. 2023.
Kretzler et al. Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease. Nat Commun. 2022.
Kretzler et al. Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network. Am J Kidney Dis. 2023.
Kretzler et al. SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes. J Clin Invest. 2023.
Kretzler et al. The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease. J Biol Chem. 2023.
Kretzler et al. Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes. Clin J Am Soc Nephrol. 2023.
Kretzler et al. The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome—a NEPTUNE cohort study. Pediatr Nephrol. 2023.
Kretzler et al. ARF6 is a host factor for SARS-CoV-2 infection in vitro. J Gen Virol. 2023.
Kretzler et al. An atlas of healthy and injured cell states and niches in the human kidney. Nature. 2023.
Kretzler et al. Dietary interventions improve diabetic kidney disease, but not peripheral neuropathy, in a db/db mouse model of type 2 diabetes. FASEB J. 2023.
Kretzler et al. Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes. Kidney Int. 2023.
Kretzler et al. Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients. J Clin Invest. 2023.
Kretzler et al. Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study. Am J Kidney Dis. 2024.
Kretzler et al. Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project. Am J Kidney Dis. 2024.
Kretzler et al. Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease. Am J Physiol Renal Physiol. 2024.
Kretzler et al. Interactive Effects of Empagliflozin and Hyperglycemia on Urinary Amino Acids in Individuals With Type 1 Diabetes. Diabetes. 2024.
Kretzler et al. TRPC6 Inhibitor BI 764198 in Focal Segmental Glomerulosclerosis: Phase 2 Study Design. Kidney Int Rep. 2023.
Kretzler et al. Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today. Kidney Int. 2024.
Kretzler et al. Multi-omics data integration shines a light on the renal medulla. Kidney Int. 2024.
Kretzler et al. Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine. Kidney Int. 2024.
Kretzler et al. The authors reply. Kidney Int. 2024.
Kretzler et al. Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury. Cell Rep. 2024.
Kretzler et al. Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response. Arthritis Rheumatol. 2024.
Kretzler et al. Identification of kidney cell types in scRNA-seq and snRNA-seq data using machine learning algorithms. Heliyon. 2024.
Kretzler et al. Development and evaluation of deep learning–based segmentation of histologic structures in the kidney cortex with multiple histologic stains. Kidney Int. 2021.
Kretzler et al. Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. Nat Genet. 2021.
Kretzler et al.Transcriptome analysis of primary podocytes reveals novel calcium regulated regulatory networks. FASEB J. 2020
Liu AP et al. Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung. Stem Cells Transl Med. 2021.
Liu et al. Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells. J Biol Chem. 2022.
Liu et al. Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation. Angew Chem Int Ed Engl. 2023.
Liu et al. DLX6-AS1 regulates odonto/osteogenic differentiation in dental pulp cells under the control of BMP9 via the miR-128-3p/MAPK14 axis: A laboratory investigation. Int Endod J. 2024.
Liu et al. The Development and Application of KinomePro-DL: A Deep Learning Based Online Small Molecule Kinome Selectivity Profiling Prediction Platform. J Chem Inf Model. 2024.
Liu et al. Genetically Supported Drug Targets and Dental Traits: A Mendelian Randomization Study. J Dent Res. 2024.
Liu L et al. MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells. Stem Cells. 2012.
Liu L et al. Mesenchymal stem cells ameliorate Th1-induced pre-eclampsia-like symptoms in mice via the suppression of TNF-α expression. PLoS One. 2014.
Liu L et al. Improving cardiac reprogramming for heart regeneration. Curr Opin Organ Transplant. 2016.
Liu L et al. Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts. Cell Discov. 2016.
Liu L et al. Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. J Biol Chem. 2019.
Mishina et al. Dynamic patterns of histone lactylation during early tooth development in mice. J Mol Histol. 2023.
Mishina et al. Enhanced BMP signaling in Cathepsin K-positive tendon progenitors induces heterotopic ossification. Biochem Biophys Res Commun. 2023.
Mishina et al. Generation of a new mouse line with conditionally activated signaling through the BMP receptor, ACVR1: A tool to characterize pleiotropic roles of BMP functions. Genesis. 2021.
Mishina et al. Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses. Bone. 2021.
Mishina et al. Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background. Genesis. 2021.
Mishina et al. Expression of Cre recombinase in chondrocytes causes abnormal craniofacial and skeletal development. Transgenic Res. 2022.
Mishina et al. Roles of osteoclasts in alveolar bone remodeling. Genesis. 2022.
Mishina et al. Activation of AcvR1-Mediated Signaling Results in Semilunar Valve Defects. J Cardiovasc Dev Dis. 2022.
Mishina et al. Enhanced BMP signaling through ALK2 attenuates keratinocyte differentiation. Biochem Biophys Res Commun. 2022.
Mishina et al. Off-target activity of the 8 kb Dmp1-Cre results in the deletion of Tsc1 gene in mouse intestinal mesenchyme. Transgenic Res. 2023.
Mishina et al. HER2 as a potential therapeutic target on quiescent prostate cancer cells. Transl Oncol. 2023.
Mishina et al. Augmentation of BMP Signaling in Cranial Neural Crest Cells Leads to Premature Cranial Sutures Fusion through Endochondral Ossification in Mice. JBMR et al. 2023.
Mishina et al. Enhanced BMP signaling leads to enlarged nasal cartilage formation in mice. Biochem Biophys Res Commun. 2023.
Mishina et al. Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme. Development. 2023.
Mishina et al. Selective Inhibition of mTORC1 Signaling Supports the Development and Maintenance of Pluripotency. Stem Cells. 2024.
Mishina et al. Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts. Elife. 2024.
Mishina et al. Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology. Proc Natl Acad Sci U S A 2024.
Mishina Y et al. Quantification of three-dimensional morphology of craniofacial mineralized tissue defects in Tgfbr2/Osx-Cre mice. Oral Sci Int. 2021.
Mishina Y et al. Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation. Sci Signal. 2021.
Mishina Y et al. Quantification of three-dimensional morphology of craniofacial mineralized tissue defects in Tgfbr2/Osx-Cre mice. Oral Sci Int. 2021.
Mishina Y et al. BMP type I receptor inhibition prevents ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva. Nat Med. 2008.
Mishina Y et al. Augmented BMP signaling in neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. Development. 2015.
Mishina Y et al. Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation. Stem Cells. 2019.
Mishina Y et al. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway. J Biol Chem. 2019.
Mishina Y et al. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat Commun. 2020.
Mishina Y et al. Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes depending on anatomical positions of the bones in mice. Bone. 2020.
Mishina Y et al. Acvr1 deletion in osteoblasts impaired mandibular bone mass through compromised osteoblast differentiation and enhanced sRANKL-induced osteoclastogenesis. J Cell Physiol. 2021.
Mishina Y et al. ALK3 Is Not Required for the Embryonic Development, Homeostasis, and Repopulation of Epidermal Langerhans Cells in Steady and Inflammatory States. J Invest Dermatol. 2021.
Mishina Y et al. Human–chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Nat Genet. 2021.
Mishina Y et al. Macropore design of tissue engineering scaffolds regulates mesenchymal stem cell differentiation fate. Biomaterials. 2021.
Mishina Y et al. mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways. Cell Rep. 2021.
Mistretta et al. The fungiform papilla is a complex, multimodal, oral sensory organ. Curr Opin Physiol. 2021.
Mistretta et al. Probing the multimodal fungiform papilla: complex peripheral nerve endings of chorda tympani taste and mechanosensitive fibers before and after Hedgehog pathway inhibition. Cell Tissue Res. 2022.
Mistretta et al. Unique lingual expression of the Hedgehog pathway antagonist Hedgehog-interacting protein in filiform papillae during homeostasis and ectopic expression in fungiform papillae during Hedgehog signaling inhibition. Dev Dyn. 2022.
Mistretta et al. Correction to: Probing the multimodal fungiform papilla: complex peripheral nerve endings of chorda tympani taste and mechanosensitive fibers before and after Hedgehog pathway inhibition (Cell and Tissue Research, (2022), 387, 2, (225-247), 10.1007/s00441-021-03561-1). Cell Tissue Res. 2022.
Mistretta et al. High-sucrose diet exposure is associated with selective and reversible alterations in the rat peripheral taste system. Curr Biol. 2022.
Mistretta et al. Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis. PLoS One. 2024.
Mycek et al. Noninvasive Optical Assessment of Implanted Tissue-Engineered Construct Success in Situ. Tissue Eng Part C Methods. 2021.
Nör et al. Propolis reduces the stemness of head and neck squamous cell carcinoma. Arch Oral Biol. 2021.
Ono et al. The diverse origin of bone-forming osteoblasts. J Bone Miner Res. 2021.
Ono et al. Diverse stem cells for periodontal tissue formation and regeneration. Genesis. 2022.
Ono N et al. Diverse contribution of Col2a1-expressing cells to the craniofacial skeletal cell lineages. Orthod Craniofac Res. 2017.
Ono N et al. Msx2 Marks Spatially Restricted Populations of Mesenchymal Precursors. J Dent Res. 2018.
Ono N et al. Resting zone of the growth plate houses a unique class of skeletal stem cells. Nature. 2018.
Ono N et al. Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells. J Bone Miner Res. 2019.
Ono N et al. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nat Commun. 2020.
Ono N et al. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nat Commun. 2020.
Parent et al. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci. 2021.
Parent et al. Loss of POGZ alters neural differentiation of human embryonic stem cells. Mol Cell Neurosci. 2022.
Parent et al. Predictors of referral for long-term EEG monitoring for Medicare beneficiaries with drug-resistant epilepsy. Epilepsia Open. 2023.
Parent et al. Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 2023.
Parent et al. Sudden Unexpected Death in Epilepsy and Respiratory Defects in a Mouse Model of DEPDC5-Related Epilepsy. Ann Neurol. 2023.
Parent et al. Deriving early single-rosette brain organoids from human pluripotent stem cells. Stem Cell Reports. 2023.
Parent et al. The role of copy number variants in the genetic architecture of common familial epilepsies. Epilepsia. 2024.
Parent et al.Seizure-Induced Neurogenesis: 1 Out of 3 Ain’t Bad. Epilepsy Curr. 2020
Parent JM et al. Critical roles of ɑII spectrin in brain development and epileptic encephalopathy. J Clin Invest. 2018.
Parent JM et al. Modeling genetic epilepsies in a dish. Dev Dyn. 2020.
Parent JM et al. Altered synaptic drive onto birthdated dentate granule cells in experimental temporal lobe epilepsy. J Neurosci. 2019.
Parent JM et al. Multimodal analysis of STRADA function in brain Development. Front Cell Neurosci. 2020.
Parent JM et al. Variant-Specific Changes in Persistent or Resurgent Sodium Current in SCN8A-Related Epilepsy Patient-Derived Neurons. Brain. 2020.
Parent JM et al. STRADA-mutant human cortical organoids model megalencephaly and exhibit delayed neuronal differentiation. Dev Neurobiol. 2021.
Popova AP et al. Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014.
Popova AP et al. Tracheal Aspirate Levels of the Matricellular Protein SPARC Predict Development of Bronchopulmonary Dysplasia. PLoS One. 2015.
Popova AP et al. Hyperoxic Exposure of Immature Mice Increases the Inflammatory Response to Subsequent Rhinovirus Infection: Association with Danger Signals. J Immunol. 2016.
Popova AP et al. Gene Expression Signatures Point to a Male Sex-Specific Lung Mesenchymal Cell PDGF Receptor Signaling Defect in Infants Developing Bronchopulmonary Dysplasia. Sci Rep. 2018.
Popova AP et al. CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia. Front Immunol. 2020.
Popova et al. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res.
Popova et al. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022.
Popova et al. Daycare Attendance is Linked to Increased Risk of Respiratory Morbidities in Children Born Preterm with Bronchopulmonary Dysplasia. J Pediatr. 2022.
Popova et al. Validation of an outpatient questionnaire for bronchopulmonary dysplasia control. Pediatr Pulmnol. 2023.
Popova et al. Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses. Front Immunol. 2023.
Popova et al. Respiratory Outcomes for Ventilator-Dependent Children With Bronchopulmonary Dysplasia. Pediatrics. 2023.
Popova et al. Number of children in the household influences respiratory morbidities in children with bronchopulmonary dysplasia in the outpatient setting. Pediatr Pulmonol. 2024.
Popova et al. Neonatal Lung Mesenchymal Stromal Cells as Early Predictors of Post-prematurity Respiratory Disease. Am J Respir Cell Mol Biol. 2024.
Rao et al. Assessing patient perception of risk in ocular stem cell therapies. Stem Cell Reports. 2021.
Rao et al. Hyperoleon: Emulsified silicone oil in anterior chamber following repair of recurrent retinal detachments [Hyperoléon: huile de silicone émulsionnée dans la chambre antérieure après réparation de décollements récurrents de la rétine]. J Fr Ophtalmol. 2023.
Rao et al. p53 inactivation unmasks histone methylation-independent WDR5 functions that drive self-renewal and differentiation of pluripotent stem cells. Stem Cell Reports. 2021.
Rao et al. RHEGMATOGENOUS RETINAL DETACHMENT AFTER INITIATION OF PILOCARPINE HYDROCHLORIDE OPHTHALMIC SOLUTION 1.25% FOR TREATMENT OF PRESBYOPIA. Retin Cases Brief Rep. 2024.
Rao et al. Congenital Horner’s syndrome observed in an adult. Can J Ophthalmol. 2023.
Rao et al. Lessons learnt, and still to learn, in first in human stem cell trials. Stem Cell Reports. 2023.
Rao et al. The Cost of Standard and Complex Pars Plana Vitrectomy for Retinal Detachment Repair Exceeds Its Reimbursement. Ophthalmol Retina. 2023.
Rao et al. Posterior Uveitis in Ocular-Involving Chronic Lymphocytic Leukemia and the Utility of Negative MYD88 L265P Testing in the Diagnosis. Ocul Oncol Pathol. 2024.
Rao et al. Liquid Biopsy for Proliferative Diabetic Retinopathy: Single-Cell Transcriptomics of Human Vitreous Reveals Inflammatory T-Cell Signature. Ophthalmol Sci. 2024.
Rao et al. A novel interaction between RNA m6A methyltransferase METTL3 and RREB1. Biochem Biophys Res Commun. 2024.
Rao RC et al. Efficient serum-free derivation of oligodendrocyte precursors from neural stem cell-enriched cultures. Stem Cells. 2009.
Rao RC et al. Dynamic patterns of histone lysine methylation in the developing retina. Invest Ophthalmol Vis Sci. 2010.
Rao RC et al. Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1. Sci Rep. 2016.
Rao RC et al. Stem Cells for Retinal Disease: A Perspective on the Promise and Perils. Am J Ophthalmol. 2017.
Rao RC et al. p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Cell Rep. 2020.
Rao RC et al. The endangered physician-scientist and COVID-19. Cell Rep Med. 2021.
Rao RC et al. Ubiquitous Chromatin Modifiers in Congenital Retinal Diseases: Implications for Disease Modeling and Regenerative Medicine. Trends Mol Med. 2021.
Rao RC et al. Research Funding, Income, and Career Satisfaction Among Clinician-Scientists in Ophthalmology in the United States. Am J Ophthalmol. 2021.
Rao RC et al. Molecular characterization of a rare case of bilateral vitreoretinal t cell lymphoma through vitreous liquid biopsy. Int J Mol Sci. 2021.
Rao RC et al. Retinal haemorrhage as a complication of blastic plasmacytoid dendritic cell neoplasm. Lancet Haematol. 2021.
Rao RC et al. Comparative molecular analysis of primary central nervous system lymphomas and matched vitreoretinal lymphomas by vitreous liquid biopsy. Int J Mol Sci. 2021.
Rui et al. Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020.
Rui et al. Leptin induces epigenetic regulation of transient receptor potential melastatin 7 in rat adrenal pheochromocytoma cells. Am J Respir Cell Mol Biol. 2021.
Rui et al. Hepatic NF-κB-Inducing Kinase and Inhibitor of NF-κB Kinase Subunit α Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury. Hepatol Commun. 2021.
Rui et al. Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis. Blood. 2022.
Rui et al. Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson’s disease via promoting PLIN4 degradation. Redox Biol. 2022.
Rui et al. Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis. Nat Metab. 2022.
Rui et al. LepRb+ cell–specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice. J Clin Invest. 2023.
Rui et al. Adipose METTL14-Elicited N6-Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing β Adrenergic Signaling and Lipolysis. Adv Sci (Weinh). 2023.
Rui et al. Simultaneous targeting of POMC and AgRP neurons. Nat Metab. 2024.
Rui et al. Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice. Cell Rep. 2024.
Rui et al. Mammalian IRE1α dynamically and functionally coalesces with stress granules. Nat Cell Biol. 2024.
Rui L et al. Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun. 2018.
Rui L et al. Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice. J Clin Invest. 2019.
Rui L et al. Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice. Proc Natl Acad Sci U S A. 2019.
Rui L et al. Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020.
Rui L et al. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. J Clin Invest. 2020.
Shea LD et al. IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury. Biotechnol Bioeng. 2021.
Smith et al. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020.
Smith et al. Lipidomic markers of sperm cryotolerance in cattle. Sci Rep. 2020.
Smith et al. Mouse oocyte vitrification with and without dimethyl sulfoxide: influence on cryo-survival, development, and maternal imprinted gene expression. J Assist Reprod Genet. 2021.
Smith et al. Microfluidic systems for isolation of spermatozoa from testicular specimens of non-obstructive azoospermic men: Does/can it improve sperm yield?. J Clin Med. 2021.
Smith et al. The Future of IVF: The New Normal in Human Reproduction. Reprod Sci. 2022.
Smith et al. Non-invasive oocyte quality assessment. Biol Reprod. 2022.
Smith et al. Regional and developmental characteristics of human embryo mosaicism revealed by single cell sequencing. PLoS Genet. 2022.
Smith et al. Derivation of spinocerebellar ataxia type 3 human embryonic stem cell line UMICHe001-A/UM134-1. Stem Cell Res. 2022.
Smith et al. Human embryos donated for human embryonic stem cell derivation. Fertil Steril. 2023.
Smith GD et al. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes. J Mol Cell Cardiol. 2016.
Smith GD et al. Targeted reactivation of FMR1 transcription in fragile X syndrome embryonic stem cells. Front Mol Neurosci. 2018.
Smith GD et al. Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line. Stem Cell Res. 2019.
Smith GD et al. Histone acetyltransferase MOF regulates fatty acid oxidation and cellular metabolism in cell fate determination. Cell Stem Cell. 2020.
Smith GD et al. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020.
Spence et al. EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids. JCI Insight. 2023.
Spence et al. Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung. Stem Cells Transl Med. 2021.
Spence et al. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2021.
Spence et al. Mapping Development of the Human Intestinal Niche at Single-Cell Resolution. Cell Stem Cell. 2021.
Spence et al. Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk. Cell Stem Cell. 2021.
Spence et al. Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model. Nucleic Acids Res. 2021.
Spence et al. SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Sci Immunol. 2021.
Spence et al. NH2-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo. Am J Physiol Gastrointest Liver Physiol. 2021.
Spence et al. Charting human development using a multi-endodermal organ atlas and organoid models. Cell. 2021.
Spence et al. Biomarkers for the Prediction and Diagnosis of Fibrostenosing Crohn’s Disease: A Systematic Review. Clin Gastroenterol Hepatol. 2022.
Spence et al. TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Nat Commun. 2021.
Spence et al. Effect of ABT-263 on Intestinal Fibrosis in Human Myofibroblasts, Human Intestinal Organoids, and the Mouse Salmonella typhimurium Model. Inflamm Bowel Dis. 2022.
Spence et al. Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids. Nat Cell Biol. 2021.
Spence et al. Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for In Vivo Detection of Sessile Serrated Adenomas. Antioxid Redox Signal. 2022.
Spence et al. Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Proc Natl Acad Sci USA. 2021.
Spence et al. Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids. PLoS Pathog. 2021.
Spence et al. Perfusion System for Modification of Luminal Contents of Human Intestinal Organoids and Realtime Imaging Analysis of Microbial Populations. Micromachines (Basel). 2022.
Spence et al. Suspension culture promotes serosal mesothelial development in human intestinal organoids. Cell Rep. 2022.
Spence et al. RSV-induced changes in a 3-dimensional organoid model of human fetal lungs. PLoS One. 2022.
Spence et al. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Nature. 2022.
Spence et al. Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation. Stem Cell Reports. 2022.
Spence et al. Rapid establishment of human colonic organoid knockout lines. STAR Protoc. 2022.
Spence et al. Vertical sleeve gastrectomy induces enteroendocrine cell differentiation of intestinal stem cells through bile acid signaling. JCI Insight. 2022.
Spence et al. Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres. Adv Mater. 2022.
Spence et al. R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development. Dev Cell. 2022.
Spence et al. Organoids as tools for fundamental discovery and translation—a Keystone Symposia report. Ann N Y Acad Sci. 2022.
Spence et al. Human neutrophil IL1β directs intestinal epithelial cell extrusion during Salmonella infection. PLoS Pathog. 2022.
Spence et al. Approaches to benchmark and characterize in vitro human model systems. Development. 2022.
Spence et al. In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice. Nat Biotechnol. 2023.
Spence et al. Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis. Adv Sci (Weinh). 2023.
Spence et al. A human liver organoid screening platform for DILI risk prediction. J Hepatol. 2023.
Spence et al. FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells. Am J Physiol Lung Cell Mol Physiol. 2023.
Spence et al. A Pilot Study: Transcriptional Profiling, Functional Analysis, and Organoid Modeling of Intestinal Mucosa in Hirschsprung Disease. J Pediatr Surg. 2023.
Spence et al. Transplanted human intestinal organoids: a resource for modeling human intestinal development. Development. 2023.
Spence et al. Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lung. Proc Natl Acad Sci U S A. 2023.
Spence et al. IL-13–induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis. J Allergy Clin Immunol. 2023.
Spence et al. Near-Infrared Imaging of Colonic Adenomas In Vivo Using Orthotopic Human Organoids for Early Cancer Detection. Cancers (Basel). 2023.
Spence et al. TGFB1 induces fetal reprogramming and enhances intestinal regeneration. Cell Stem Cell. 2023.
Spence et al. Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon. Cell Stem Cell. 2023.
Spence et al. Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection. J Virol. 2023.
Spence et al. Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease. iScience. 2023.
Spence et al. A patterned human neural tube model using microfluidic gradients. Nature. 2024.
Spence et al. Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung. J Med Chem. 2024.
Spence et al. GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function. Mol Cancer Res. 2024.
Spence et al.The Lumen of Human Intestinal Organoids Poses Greater Stress to Bacteria Compared to the Germ-Free Mouse Intestine: Escherichia coli Deficient in RpoS as a Colonization Probe. mSphere. 2020
Spence et al.Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures. Front Cell Dev Biol. 2020
Wang CW Is periodontal phenotypic conversion therapy beneficial for patients receiving orthodontic treatment? An American Academy of Periodontology Best Evidence Review. J Periodontol. 2020.
Wang et al. Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation. Elife. 2021.
Wang et al. Liquid-like thermal conductivity in solid materials: Dynamic behavior of silver ions in argyrodites. Nano Energy. 2024.
Wang et al. High-order harmonics and the reverse of the squaring up process in the triangular-lattice magnet HoPdAl4Ge2. Phys Rev B. 2024.
Wang Z et al. HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction. EBioMedicine. 2019.
Wang Z et al. Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. J Biol Chem. 2019.
Wang Z et al. SWI/SNF component BAF250a coordinates OCT4 and WNT signaling pathway to control cardiac lineage differentiation. Front Cell Dev Biol. 2020.
Wang Z et al. Biodegradable nanofibrous temperature-responsive gelling microspheres for heart regeneration. Adv Funct Mater. 2020.
Wang Z et al. Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation. Physiol Rep. 2021.
Wang Z et al. Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via mediating histone acetylation. bioRxiv. 2019.
Yang B et al. Thoracic Endovascular Aortic Repair in the Setting of Compromised Distal Landing Zones. Ann Thorac Surg. 2021.
Yang B et al. Reply: Thoracic Endovascular Aortic Repair versus Fenestration/Stenting: both effective weapons for the same disease. J Thorac Cardiovasc Surg. 2021.