Cell Therapy
Cell therapy harnesses the innate and engineered ability of transplanted cells to direct tissue regeneration or restoration in a controlled manner. Research endeavors include techniques to modify cell functionality as well as approaches to engineer its microenvironment to promote tissue healing.
Researchers
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Carlos AguilarEngineering -
Andrea AlfordMedicine -
Steven BuchmanMedicine -
Rhima ColemanEngineering -
Joseph DeckerDentistry -
Gregory DresslerMedicine -
Mario FabiilliMedicine -
Stephen FeinbergDentistry -
Eva FeldmanMedicine -
Renny FranceschiDentistry -
Jianping FuEngineering -
Katherine GallagherMedicine -
Kurt HankensonMedicine -
Todd HerronMedicine -
Darnell KaiglerDentistry -
David KohnDentistry -
Liu LiuMedicine -
Isabelle LombaertDentistry -
Yuji MishinaDentistry -
Aaron MorrisEngineering -
Jacques NörDentistry -
Jack ParentMedicine -
Andy PutnamEngineering -
Indika RajapakseMedicine -
Rajesh RaoMedicine -
Lonnie SheaEngineering -
Ariella ShikanovEngineering -
Scott SoleimanpourMedicine -
Lauren SurfaceDentistry -
Zhong WangMedicine
Select Publications
Aguilar CA et al. Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma. Stem Cell Reports. 2016.
Aguilar CA et al. Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury. Cell Death Discov. 2018.
Aguilar CA et al. Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. J Immunology. 2020.
Aguilar CA et al. Dissecting murine muscle stem cell aging through integrative genomic analysis. Cell Rep. 2020.
Aguilar CA et al. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight. 2020.
Aguilar CA et al. Engineered Tools to Study Intercellular Communication. Adv Sci (Weinh). 2021.
Aguilar CA et al. Metabolipidomic profiling reveals an age-related deficiency of skeletal muscle pro-resolving mediators that contributes to maladaptive tissue remodeling. Aging Cell. 2021.
Aguilar CA et al. Sestrins regulate muscle stem cell metabolic homeostasis. Stem Cell Reports. 2021.
Aguilar et al. Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Commun Biol. 2020.
Aguilar et al. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci U S A. 2022.
Aguilar et al. Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma. Ann Surg. 2023.
Aguilar et al. Three-dimensional chromatin re-organization during muscle stem cell aging. Aging Cell. 2023.
Aguilar et al. Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss. JCI Insight. 2023.
Alford AI et al. Two molecular weight species of thrombospondin-2 are present in bone and differentially modulated in fractured and nonfractured tibiae in a murine model of bone healing. Calcif Tissue Int. 2012.
Alford AI et al. Thrombospondin-2 facilitates assembly of a type-I collagen rich matrix in marrow stromal cells undergoing osteoblastic differentiation. Connect Tissue Res. 2013.
Alford AI et al. Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype. J Appl Physiol. 1985.
Alford AI et al. TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro. Connect Tissue Res. 2019.
Alford AI et al. Evaluation of global gene expression in regenerate tissues during Masquelet treatment. J Orthop Res. 2020.
Alford AI et al. Intersite reliability of vertebral bone marrow lipidomics-derived lipid composition among children with varying degrees of bone fragility undergoing routine orthopedic surgery. Bone. 2021.
Alford AI et al. Pattern of bone marrow lipid composition measures along the vertebral column: A descriptive study of adolescents with idiopathic scoliosis. Bone. 2021.
Alford AI et al. Masquelet’s induced membrane technique: Review of current concepts and future directions. J Orthop Res. 2021.
Alford et al. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts. Bone. 2021.
Alford et al. Comparison of true blood loss between short and long cephalomedullary nail fixation of geriatric hip fractures, a retrospective cohort study. Eur J Orthop Surg Traumatol. 2023.
Alford et al. Thrombospondins modulate cell function and tissue structure in the skeleton. Semin Cell Dev Biol. 2024.
Besirli et al. Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database. Eur J Ophthalmol. 2022.
Besirli et al. Perifoveal Chorioretinal Atrophy after Subretinal Voretigene Neparvovec-rzyl for RPE65-Mediated Leber Congenital Amaurosis. Ophthalmol Retina. 2022.
Besirli et al. Referable Macular Hemorrhage-A Clinically Meaningful Screening Target in Newborn Infants. Position Statement of the Association of Pediatric Retina Surgeons. Ophthalmic Surg Lasers Imaging Retina. 2022.
Besirli et al. Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration. Nanomedicine. 2022.
Besirli et al. Surgical repair of primary non-complex rhegmatogenous retinal detachment in the modern era of small-gauge vitrectomy. BMJ Open Opthalmology 2021.
Besirli et al. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis. Sci Rep. 2020.
Besirli et al. Coats-like Exudative Vitreoretinopathy in Retinitis Pigmentosa: Ocular Manifestations and Treatment Outcomes. Opthalmol Retina. 2021.
Besirli et al. Cryotherapy for the management of refractory hypotony secondary to post-goniotomy cyclodialysis cleft. Am J Ophthalmol Case Rep. 2020.
Besirli et al. Novel TMEM98, MFRP, PRSS56 variants in a large United States high hyperopia and nanophthalmos cohort. Sci Rep. 2020.
Besirli et al. A novel OCT signature in leukemic papillopathy masquerading as autoimmune or infectious uveitis. Graefes Arch Clin Exp Opthalmol. 2021.
Besirli et al. Autophagy activation and photoreceptor survival in retinal detachment. Exp Eye Res. 2021.
Besirli et al. Outcomes of Baerveldt Glaucoma Drainage Devices in Pediatric Eyes. J Glaucoma. 2022.
Besirli et al. Real-world outcomes of voretigene neparvovec treatment in pediatric patients with RPE65-associated Leber congenital amaurosis. Graefes Arch Clin Exp Ophthalmol. 2022.
Besirli et al. Scleral Histopathologic Findings of Hurler-Scheie Syndrome with Refractory Glaucoma. JAMA Ophthalmol. 2022.
Besirli et al. Late Vitreoretinal Complications of Regressed Retinopathy of Prematurity: Retinal Break, Vitreous Hemorrhage, and Retinal Detachment. Ophthalmol Retina. 2023.
Besirli et al. Practice Patterns and Outcomes of Intravitreal Anti-VEGF Injection for Retinopathy of Prematurity: An International Multicenter Study. Ophthalmology. 2022.
Besirli et al. A Caveat About Financial Incentives for Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Retinopathy. Am J Ophthalmol. 2022.
Besirli et al. COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM AT PEDIATRIC AGE: Surgical Versus Conservative Approach. Retina. 2023.
Besirli et al. Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity: A Multicenter Study. Ophthalmology. 2023.
Besirli et al. Retinal Neovascularization in Posterior Polar Annular Choroidal Dystrophy. JAMA Ophthalmol. 2023.
Besirli et al. Scleral Windows in the Treatment of Uveal Effusion Syndrome. Ophthalmic Surg Lasers Imaging Retina. 2022.
Besirli et al. Quantitative analysis of tear angiogenic factors in retinopathy of prematurity: a pilot biomarker study. J AAPOS. 2023.
Besirli et al. The impact of the COVID-19 lockdown on retinopathy of prematurity screening and management in the United States: a multicenter study. J AAPOS. 2023.
Besirli et al. First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children With CNGB3-associated Achromatopsia. Am J Ophthalmol. 2023.
Besirli et al. Flow cytometric method for the detection and quantification of retinal cell death and oxidative stress. Exp Eye Res. 2023.
Besirli et al. Cataractous remnants form a free-floating cystic structure in a unicameral pediatric eye. Am J Ophthalmol Case Rep. 2023.
Besirli et al. Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration. Cells. 2023.
Besirli, et al. Characteristics of Retinal Detachment after Pediatric Open-Globe Injuries. Ophthalmol Retina. 2021.
Buchman et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Buchman et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Buchman et al. Institutional trends in opioid prescribing and utilization after primary cleft lip and palate repair. Plast Reconstr Surg. 2022.
Buchman et al. Reply: Management of Calcified Cephalohematoma of Infancy: The University of Michigan 25-Year Experience. Plast Reconstr Surg. 2022.
Buchman et al. Surgical Timing and Neurocognitive Development among Patients with Craniosynostosis: Analysis of Confounders. Plast Reconstr Surg. 2023.
Buchman et al. Managing the Soft-Tissue Envelope in Facial Feminization Surgery: Filling and Tightening Surgical Approaches. Plast Reconstr Surg. 2023.
Buchman et al. Longitudinal Assessment of Neurodevelopment in Patients With Nonsyndromic Single-Suture Craniosynostosis: A Retrospective Review of 66 Patients. J Craniofac Surg. 2023.
Buchman et al. Adipose-Derived Stem Cells Enhance Graft Incorporation and Mineralization in a Murine Model of Irradiated Mandibular Nonvascularized Bone Grafting. Ann Plast Surg. 2023.
Buchman et al. H vessel formation as a marker for enhanced bone healing in irradiated distraction osteogenesis. Semin Plast Surg. 2024.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Coleman et al. Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies. Curr Rheumatol Rep. 2022.
Coleman et al. Cartilage thickness mismatches in patellar osteochondral allograft transplants affect local cartilage stresses. J Orthop Res. 2023.
Dressler et al. Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021.
Dressler et al. Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation. Cell Chem Biol. 2022.
Dressler et al. Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease. Kidney Int. 2024.
Dressler et al. Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury. Am J Physiol Renal Physiol. 2024.
Fabiili et al. Real-time spatiotemporal characterization of mechanics and sonoporation of acoustic droplet vaporization in acoustically responsive scaffolds. Appl Phys Lett. 2023.
Fabiilli et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.
Fabiilli et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.
Fabiilli et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Fabiilli et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.
Fabiilli et al. Slow-Flow Ultrasound Localization Microscopy Using Recondensation of Perfluoropentane Nanodroplets. Ultrasound Med Biol. 2022.
Fabiilli et al. Multi-time scale characterization of acoustic droplet vaporization and payload release of phase-shift emulsions using high-speed microscopy. Ultrason Sonochem. 2022.
Fabiilli et al. Pressure Measurement in a Bladder Phantom Using Contrast-Enhanced Ultrasonography – A Path to a Catheter-Free Voiding Cystometrogram. Invest Radiol. 2023.
Fabiilli et al. Ultrasound Contrast Stability for Urinary Bladder Pressure Measurement. Ultrasound Med Biol. 2023.
Fabiilli et al. Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber Model In Vivo. Tissue Eng Part C Methods. 2024.
Fabiilli ML et al. Spatiotemporally-controlled transgene expression in hydroxyapatite-fibrin composite scaffolds using high intensity focused ultrasound. Biomaterials. 2019.
Fabiilli ML et al. Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation. Acta Biomater. 2019.
Fabiilli ML et al. Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds. Ultrason Sonochem. 2020.
Fabiilli ML et al. Spatially-directed cell migration in acoustically-responsive scaffolds via the controlled delivery of basic fibroblast growth factor. Acta Biomater. 2020.
Fabiilli ML et al. Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization. Soft Matter. 2020.
Fabilli et al. Ultra-high-speed dynamics of acoustic droplet vaporization in soft biomaterials: Effects of viscoelasticity, frequency, and bulk boiling point. Ultrason Sonochem. 2024.
Feinberg SE et al. Tissue engineering of lips and muco-cutaneous junctions: in vitro development of tissue engineered constructs of oral mucosa and skin for lip reconstruction. Tissue Eng Part C Methods. 2012.
Feinberg SE et al. Intraoral grafting of tissue-engineered human oral mucosa. Int J Oral Maxillofac Implants. 2013.
Feinberg SE et al. Fabrication of Large Size Ex Vivo-Produced Oral Mucosal Equivalents for Clinical Application. Tissue Eng Part C Methods. 2015.
Feinberg SE et al. In Vitro Development of a Mucocutaneous Junction for Lip Reconstruction. J Oral Maxillofac Surg. 2016.
Feinberg SE et al. Soft Tissue Engineering. Oral Maxillofac Surg Clin North Am. 2017.
Feldman EL et al. Human neural stem cell transplantation into the corpus callosum of Alzheimer’s mice. Ann Clin Transl Neurol. 2017.
Feldman EL et al. Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS. Ann Clin Transl Neurol. 2018.
Feldman EL et al. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep. 2018.
Feldman EL et al. Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials. Expert Opin Investig Drugs. 2019.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2020.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2021.
Feldman EL et al. Diabetic neuropathy in children and youth: New and emerging risk factors. Pediatr Diabetes. 2021.
Feldman EL et al. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron. 2021.
Feldman EL et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Feldman EL et al. Amyotrophic Lateral Sclerosis Survival Associates With Neutrophils in a Sex-specific Manner. Neurol Neuroimmunol Neuroinflamm. 2021.
Feldman EL et al. Immune-mediated vincristine-induced neuropathy: Unlocking therapies. J Exp Med. 2021.
Feldman EL et al. Lessons for clinical trial design in Friedreich’s ataxia. Lancet Neurol. 2021.
Feldman EL et al. High dietary fat consumption impairs axonal mitochondrial function in Vivo. J Neurosci. 2021.
Feldman EL et al. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. Faseb J. 2021.
Feldman EL et al. Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes. Ann Clin Transl Neurol. 2021.
Feldman EL et al. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight 2021.
Feldman EL et al. The determinants of complication trajectories in American Indians with type 2 diabetes. JCI Insight. 2021.
Feldman EL et al. Inclusion body myositis: small steps towards future advances. Lanc Rheum. 2021.
Feldman et al. Untargeted metabolomics yields insight into ALS disease mechanisms. J Neurol Neurosurg Psychiatry. 2020.
Feldman et al. Covid-19 and diabetes: A collision and collusion of two diseases. Diabetes. 2020.
Feldman et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Feldman et al. Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact. Neurosci Biobehav Rev. 2021.
Feldman et al. Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis. JAMA Neurol. 2021.
Feldman et al. Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology. Obesity (Silver Spring). 2021.
Feldman et al. Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy. Dis Model Mech. 2021.
Feldman et al. Nox, Nox, Are You There? the Role of NADPH Oxidases in the Peripheral Nervous System. Antioxid Redox Signal. 2022.
Feldman et al. Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts. Brain. 2022.
Feldman et al. A Role for Fatty Acids in Peripheral Neuropathy Associated with Type 2 Diabetes and Prediabetes. Antioxid Redox Signal. 2022.
Feldman et al. Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis. Front Immunol. 2022.
Feldman et al. Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. Lancet Neurol. 2022.
Feldman et al. Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis. Lancet Neurol. 2022.
Feldman et al. Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infection. Neurobiol Dis. 2022.
Feldman et al. Glial-neuron crosstalk in health and disease: A focus on metabolism, obesity, and cognitive impairment. Neurobiok Dis. 2022.
Feldman et al. Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes. Ann Clin Transl Neurol. 2022.
Feldman et al. The Impact of the COVID-19 Pandemic on Ethnic Minority Groups With Diabetes. Diabetes Care. 2023.
Feldman et al. Amyotrophic lateral sclerosis from genotoxins alone? – Authors’ reply. Lancet Neurol. 2022.
Feldman et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022.
Feldman et al. miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis. Hum Mol Genet. 2023.
Feldman et al. Diabetes and dementia: Clinical perspective, innovation, knowledge gaps. J Diabetes Complications. 2022.
Feldman et al. The conundrum of diabetic neuropathies—Past, present, and future. J Diabetes Complications. 2022.
Feldman et al. Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles. Muscle Nerve. 2023.
Feldman et al. Patient and health care provider knowledge of diabetes and diabetic microvascular complications: a comprehensive literature review. Rev Endocr Metab Disord. 2023.
Feldman et al. ISPAD Clinical Practice Consensus Guidelines 2022: Microvascular and macrovascular complications in children and adolescents with diabetes. Pediatr Diabetes. 2022.
Feldman et al. Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice. Immun Ageing. 2022.
Feldman et al. Disrupted axon-glia communication leads to neurodegeneration in metabolic diseases. Neurobiol Dis. 2023.
Feldman et al. A roadmap to ALS prevention: Strategies and priorities. J Neurol Neurosurg Psychiatry. 2023.
Feldman et al. The determinants of complication trajectories in American Indians with type 2 diabetes. JCI Insight. 2023.
Feldman et al. Treatment-induced neuropathy of diabetes: an underdiagnosed entity – Authors’ reply. Lancet Neurol. 2023.
Feldman et al. The effect of surgical weight loss on diabetes complications in individuals with class II/III obesity. Diabetologia. 2023.
Feldman et al. Advances in diagnosis and management of distal sensory polyneuropathies. J Neurol Neurosurg Psychitry. 2023.
Feldman et al. New perspectives in diabetic neuropathy. Neuron. 2023.
Feldman et al. Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells. Ann Clin Transl Neurol. 2023.
Feldman et al. Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination. J Neurochem. 2023.
Feldman et al. Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementias. Cell Genom. 2023.
Feldman et al. Association between brain health outcomes and metabolic risk factors in persons with diabetes. Ann Clin Transl Neurol. 2023.
Feldman et al. The amyotrophic lateral sclerosis exposome: recent advances and future directions. Nat Rev Neurol. 2023.
Feldman et al. Gut microbiome correlates with plasma lipids in amyotrophic lateral sclerosis. Brain. 2024.
Feldman et al. Cost and utilization of healthcare services for persons with diabetes. Diabetes Res Clin Pract. 2023.
Feldman et al. Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer’s disease. J Extracell Vesicles. 2023.
Feldman et al. The Effect of Surgical Weight Loss on Cognition in Individuals with Class II/III Obesity. J Nutr Health Aging. 2023.
Feldman et al. Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study. J Neurol Sci. 2024.
Feldman et al.Differential effects of empagliflozin on microvascular complications in murine models of type 1 and type 2 diabetes. Biology (Basel). 2020
Franceschi et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.
Franceschi et al. Role of Runx2 in prostate development and stem cell function. Prostate. 2021.
Franceschi et al. Role of Discoidin Domain Receptor 2 in Craniofacial Bone Regeneration. J Dent Res. 2021.
Franceschi et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Franceschi et al. Expression of Beta-Catenin, Cadherins and P-Runx2 in Fibro-Osseous Lesions of the Jaw: Tissue Microarray Study. Biomolecules. 2022.
Franceschi et al. Cranial Base Synchondrosis: Chondrocytes at the Hub. Int J Mol Sci. 2022.
Franceschi et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022.
Franceschi et al. Control of Craniofacial Development by the Collagen Receptor, Discoidin Domain Receptor 2. Elife. 2023.
Franceschi et al. Acoustic droplet vaporization for on-demand modulation of microporosity in smart hydrogels. Acta Biomater. 2023.
Franceschi et al. Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells. Acta Biomater. 2023.
Franceschi RT et al. Advanced BMP gene therapies for temporal and spatial control of bone regeneration. J Dent Res. 2013.
Franceschi RT et al. Discoidin Domain Receptor 2 Controls Bone Formation and Marrow Adipogenesis. J Bone Miner Res. 2016.
Franceschi RT et al. Control of the osteoblast lineage by mitogen-activated protein kinase signaling. Curr Mol Biol Rep. 2017.
Franceschi RT et al. Selective Role of Discoidin Domain Receptor 2 in Murine Temporomandibular Joint Development and Aging. J Dent Res. 2018.
Franceschi RT et al. Genetic inhibition of PPAR-gamma S112 phosphorylation reduces bone formation and stimulates marrow adipogenesis. Bone. 2018.
Franceschi RT et al. Patient perceptions of SARS-CoV-2 exposure risk and association with continuity of ophthalmic care. JAMA Opthalmol. 2021.
Franceschi RT et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.
Fu et al. Branching development of early post-implantation human embryonic-like tissues in 3D stem cell culture. Biomaterials. 2021.
Fu et al. Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation. Nano Today. 2021.
Fu et al. Elucidating the behavior of trophectoderm derivatives in mouse implantation. Dev Cell. 2022.
Fu et al. Engineering multiscale structural orders for high-fidelity embryoids and organoids. Cell Stem Cell. 2022.
Fu et al. In vitro germ cell induction from fertile and infertile monozygotic twin research participants. Cell Rep Med. 2022.
Fu et al. Modeling development using microfluidics: bridging gaps to foster fundamental and translational research. Curr Opin Genet Dev. 2023.
Fu et al. Why researchers should use human embryo models with caution. Nature. 2023.
Fu et al. A Definition of Neuromodulation and Classification of Implantable Electrical Modulation for Chronic Pain. Neuromodulation. 2024.
Fu et al. Changing the public perception of human embryology. Nat Cell Bio. 2023.
Fu et al. The role of copy number variants in the genetic architecture of common familial epilepsies. Epilepsia. 2024.
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Fu J et al. Stem-cell-based embryo models for fundamental research and translation. Nat Mater. 2021.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Hankenson et al. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts. Bone. 2021.
Hankenson et al. Constitutive bone marrow adipocytes suppress local bone formation. JCI Insight. 2022.
Hankenson et al. Stereochemistry Determines Immune Cellular Responses to Polylactide Implants. ACS Biomater Sci Eng. 2023.
Hankenson et al. The multifaceted role of mast cells in joint inflammation and arthritis. Osteoarthritis Cartilage. 2023.
Hankenson et al. Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing. Bone. 2023.
Hankenson et al. Comparison of true blood loss between short and long cephalomedullary nail fixation of geriatric hip fractures, a retrospective cohort study. Eur J Orthop Surg Traumatol. 2023.
Hankenson et al. Thrombospondins modulate cell function and tissue structure in the skeleton. Semin Cell Dev Biol. 2024.
Hankenson et al. Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming. Adv Sci (Weinh). 2023.
Hankenson et al. Silver-releasing bioactive glass nanoparticles for infected tissue regeneration. Biomater Adv. 2023.
Hankenson et al. Tailored Coatings for Enhanced Performance of Zinc-Magnesium Alloys in Absorbable Implants. ACS Biomater Sci Eng. 2024.
Hankenson et al. Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements. EBioMedicine. 2024.
Hankenson KD et al. Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regen Med. 2017.
Hankenson KD et al. R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Bone Res. 2018.
Hankenson KD et al. Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density. Nat Commun. 2019.
Hankenson KD et al. CTRP3 Regulates Endochondral Ossification and Bone Remodeling During Fracture Healing. J Orthop Res. 2020.
Hankenson KD et al. Thrombospondin-2 spatiotemporal expression in skeletal fractures. J Orthop Res. 2021.
Hankenson KD et al. Canonical Notch signaling is required for bone morphogenetic protein-mediated human osteoblast differentiation. Stem Cells. 2020.
Hankenson KD et al. Biological constraints on gwas snps at suggestive significance thresholds reveal additional bmi loci. Elife. 2021.
Hankenson KD et al. Silver-doped bioactive glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant Staphylococcus aureus (MRSA) inhibition. Mater Sci Eng C Mater Biol Appl. 2021.
Hankenson KD et al. CRISPR-Cas9–Mediated Genome Editing Confirms EPDR1 as an Effector Gene at the BMD GWAS-Implicated ‘STARD3NL’ Locus. JBMR Plus. 2021.
Hankerson et al. Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma. Ann Surg. 2023.
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