Biomechanics

Biomechanics is a central theme in regenerative medicine where research explores biological processes and mechanics, ranging from the molecular to organism levels. This knowledge is leveraged to improve outcomes of tissue regeneration and restoration.

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Researchers

Andrea Alford

Medicine
Brendon Baker

Medicine
Paul Cederna

Medicine
Rhima Coleman

Engineering
Cheri Deng

Engineering
Sean Edwards

Dentistry
Mario Fabiilli

Medicine
Renny Franceschi

Dentistry
Jianping Fu

Engineering
Deanna Gates

LSA
Idse Heemskerk

Medicine
Evan Keller

Medicine
Stephen Kemp

Medicine
Megan Killian

Medicine
David Kohn

Dentistry
Ken Kozloff

Medicine
Andy Putnam

Engineering
David Zopf

Medicine

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Abraham A et al. Cell lineage tracing and functional assessment of supraspinatus tendon healing in an acute repair murine model. J Orthop Res. 2021.
Abraham et al. Physical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels. Adv Funct Mater. 2022.
Abraham et al. The role of loading in murine models of rotator cuff disease. J Orthop Res. 2022.
Abraham et al. Comparison of Distal Spine Anchors and Distal Pelvic Anchors in Children with Hypotonic Neuromuscular Scoliosis Treated with Growth-friendly Instrumentation. J Pediatr Orthop. 2023.
Abraham et al. Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice. Sci Adv. 2023.
Abraham et al. A role for TGFβ signaling in Gli1+ tendon and enthesis cells. FASEB J. 2024.
Abraham et al. Nuclear factor κB overactivation in the intervertebral disc leads to macrophage recruitment and severe disc degeneration. Sci Adv. 2024.
Abraham et al. Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle. FASEB J. 2024.
Alford AI et al. Two molecular weight species of thrombospondin-2 are present in bone and differentially modulated in fractured and nonfractured tibiae in a murine model of bone healing. Calcif Tissue Int. 2012.
Alford AI et al. Thrombospondin-2 facilitates assembly of a type-I collagen rich matrix in marrow stromal cells undergoing osteoblastic differentiation. Connect Tissue Res. 2013.
Alford AI et al. Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype. J Appl Physiol. 1985.
Alford AI et al. TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro. Connect Tissue Res. 2019.
Alford AI et al. Evaluation of global gene expression in regenerate tissues during Masquelet treatment. J Orthop Res. 2020.
Alford AI et al. Intersite reliability of vertebral bone marrow lipidomics-derived lipid composition among children with varying degrees of bone fragility undergoing routine orthopedic surgery. Bone. 2021.
Alford AI et al. Pattern of bone marrow lipid composition measures along the vertebral column: A descriptive study of adolescents with idiopathic scoliosis. Bone. 2021.
Alford AI et al. Masquelet’s induced membrane technique: Review of current concepts and future directions. J Orthop Res. 2021.
Alford et al. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts. Bone. 2021.
Alford et al. Comparison of true blood loss between short and long cephalomedullary nail fixation of geriatric hip fractures, a retrospective cohort study. Eur J Orthop Surg Traumatol. 2023.
Alford et al. Thrombospondins modulate cell function and tissue structure in the skeleton. Semin Cell Dev Biol. 2024.
Arruda et al. Investigation of Fiber-Driven Mechanical Behavior of Human and Porcine Bladder Tissue Tested Under Identical Conditions. J Biomech Eng. 2021.
Arruda et al. The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review. J Biomech Eng. 2022.
Arruda et al. Ogden material calibration via magnetic resonance cartography, parameter sensitivity and variational system identification. Philos Trans A Math Phys Eng Sci. 2022.
Arruda et al. Topological transformability and reprogrammability of multistable mechanical metamaterials. Proc Natl Acad Sci U S A. 2022.
Arruda et al. Cartilage thickness mismatches in patellar osteochondral allograft transplants affect local cartilage stresses. J Orthop Res. 2023.
Arruda et al. Constitutive modeling of the anterior cruciate ligament bundles and patellar tendon with full-field methods. J Mech Phys Solids. 2021.
Arruda et al. Inference of deformation mechanisms and constitutive response of soft material surrogates of biological tissue by full-field characterization and data-driven variational system identification. J Mech A Solid 2021.
Arruda et al. Free vibration of thin, creased elastic plates: Optimization and scaling laws. Thin-Walled Struct. 2024.
Arruda et al. Fractional topological solitons in nonlinear viscoelastic ribbons with tunable speed. Extreme Mech Lett. 2023.
Baker BM et al. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017.
Baker BM et al. Cell force-mediated matrix reorganization underlies multicellular network assembly. Sci Rep. 2019.
Baker BM et al. Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration. Nat Commun. 2019.
Baker BM et al. Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Lab Chip. 2020.
Baker BM et al. Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis. Sci Adv. 2020.
Baker BM et al. Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices. Biomater Sci. 2021.
Baker BM et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.
Baker BM et al. Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform. Lab Chip. 2021.
Baker BM et al. New directions and dimensions for bioengineered models of fibrosis. Nat Review Mater. 2021.
Baker BM et al. Quantification and immunoprofiling of bladder cancer cell-derived extracellular vesicles with microfluidic chemiluminescent ELISA. Biosens Bioelectron: X. 2021.
Baker et al. Physical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels. Adv Funct Mater. 2022.
Baker et al. Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation. Acta Biomater. 2021.
Baker et al. Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology. Adv Mater. 2021.
Baker et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Baker et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.
Baker et al. Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D. Adv Sci (weinh). 2022.
Baker et al. The living interface between synthetic biology and biomaterial design. Nat Mater. 2022.
Baker et al. Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel. Acta Biomater. 2023.
Baker et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022.
Baker et al. A data-driven computational model for engineered cardiac microtissues. Acta Biomater. 2023.
Baker et al. Mechanical Intercellular Communication via Matrix-Borne Cell Force Transmission During Vascular Network Formation. Adv Sci (Weinh). 2024.
Baker et al. Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease. iScience. 2023.
Baker et al. Sulfide oxidation promotes hypoxic angiogenesis and neovascularization. Nat Chem Biol. 2024.
Baker et al. MicroBundleCompute: Automated segmentation, tracking, and analysis of subdomain deformation in cardiac microbundles. PLoS One. 2024.
Baker et al. A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses. Adv Funct Mater. 2024.
Baker et al. Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites. Adv Healthc Mater. 2024.
Cederna et al. Commentary on: Resident Exposure to Aesthetic Surgical and Nonsurgical Procedures during Canadian Residency Program Training. Aesthet Surg J. 2021.
Cederna et al. Comparison of Outcomes of Spinal Accessory to Suprascapular Nerve Transfer Versus Nerve Grafting for Neonatal Brachial Plexus Injury. Orthopedics. 2022.
Cederna et al. The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals. J Vis Exp. 2022.
Cederna et al. Meshach Haskell (Hack) Newman, M.S., M.D., 1937 to 2021. Plast Reconstr Surg. 2022.
Cederna et al. Aesthetic Surgery in Plastic Surgery Academia. Aesthet Surg J. 2021.
Cederna et al. Regenerative Peripheral Nerve Interfaces for Advanced Control of Upper Extremity Prosthetic Devices. Hand Clin. 2021.
Cederna et al. Neuroma, Neural Interface, and Prosthetics. Hand Clin. 2021.
Cederna et al. Gender Affirming Mastectomy Improves Quality of Life in Transmasculine Patients: A Single-center Prospective Study. Ann Surg. 2023.
Cederna et al. Impact of Cell Seeding Density and Cell Confluence on Human Tissue Engineered Skeletal Muscle. Tissue Eng Part A. 2022.
Cederna et al. “Decreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)”. Ann Vasc Surg. 2022.
Cederna et al. The Current State of Fat Grafting in the Hand: A Systematic Review for Hand Diseases. Hand (N Y). 2023.
Cederna et al. Reply: Facial Transplantation: A Dilemma of the Four Basic Medical Ethics Principles. Plast Reconstr Surg. 2022.
Cederna et al. Sensory nerve regeneration and reinnervation in muscle following peripheral nerve injury. Musle Nerve. 2022.
Cederna et al. Pathophysiological and Neuroplastic Changes in Postamputation and Neuropathic Pain: Review of the Literature. Plast Reconstr Surg Glob Open. 2022.
Cederna et al. From Here to There: A Celebration of the Life and Contributions of Reed O. Dingman. J Craniofac Surg. 2023.
Cederna et al. Ultrasound appearance of regenerative peripheral nerve interface with clinical correlation. Skeletal Radiol. 2023.
Cederna et al. Upper limb prostheses: bridging the sensory gap. J Hand Surg Eur Vol. 2023.
Cederna et al. Dermal Sensory Regenerative Peripheral Nerve Interface for Reestablishing Sensory Nerve Feedback in Peripheral Afferents in the Rat. Plast Reconstr Surg. 2023.
Cederna et al. Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes. J Neural Eng. 2023.
Cederna et al. Technical Precision with Autologous Fat Grafting for Facial Rejuvenation: A Review of the Evolving Science. Plast Reconstr Surg. 2024.
Cederna et al. Augmenting Medical and Surgical Education with Virtual Reality. Plast Reconstr Surg. 2023.
Cederna et al. Regenerative Peripheral Nerve Interface Surgery: Anatomic and Technical Guide. Plast Reconstr Surg Glob Open. 2023.
Cederna et al. Realizing Upper Extremity Bionic Limbs: Leveraging Neuroprosthetic Control Strategies. Plast Reconstr Surg. 2024.
Cederna et al. REGENERATIVE PERIPHERAL NERVE INTERFACE (RPNI) SURGERY FOR MITIGATION OF NEUROMA AND POSTAMPUTATION PAIN. JBJS Essent Surg Tech. 2024.
Cederna et al. Merging humans and neuroprosthetics through regenerative peripheral nerve interfaces. Semin Plast Surg. 2024.
Cederna et al. Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain. J Vis Exp. 2024.
Cederna et al. Integration of Virtual and Traditional Medical Education: Scholarship Pivots from the COVID-19 Pandemic. Plast Reconstr Surg Glob Open. 2024.
Cederna et al. Transparency in Plastic Surgery Program Accreditation. J Grad Med Educ. 2024.
Cederna et al. Amputation Surgery: Review of New and Emerging Techniques. Phys Med Rehabil Clin N Am. 2024.
Cederna PS et al. Chronic Recording of Hand Prosthesis Control Signals Via a Regenerative Peripheral In a Rhesus Macaque. J Neural Eng. 2016.
Cederna PS et al. The Regenerative Peripheral Nerve Interface for Neuroma Management. JAMA Surg. 2018.
Cederna PS et al. Prosthetic Rehabilitation and Vascularized Composite Allotransplantation Following Upper Limb Loss. Plast Reconstr Surg. 2019.
Cederna PS et al. Prophylactic Regenerative Peripheral Nerve Interfaces (RPNIs) to Prevent Postamputation Pain. Plast Reconstr Surg. 2019.
Cederna PS et al. A Regenerative Peripheral Nerve Interface Allows Real-Time Control of an Artificial Hand In Upper Limb Amputees. Sci Transl Med. 2020.
Cederna PS et al. Developing Strategies for Targeted Improvement of Perioperative Education for Postbariatric Surgery Body-Contouring Patients. Ann Plast Surg. 2021.
Cederna PS et al. Commentary on: Trends and challenges of telehealth in an academic institution: The unforeseen benefits of the COVID-19 global pandemic. Aesthet Surg J. 2021.
Cederna PS et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Cederna PS et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Coleman et al. Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies. Curr Rheumatol Rep. 2022.
Coleman et al. Cartilage thickness mismatches in patellar osteochondral allograft transplants affect local cartilage stresses. J Orthop Res. 2023.
Coleman et al. Osteoporosis GWAS-implicated DNM3 locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels. JBMR Plus. 2024.
Deng CX et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
Deng CX et al. Microscale Characterization of the Viscoelastic Properties of Hydrogel Biomaterials using Ultrasound Technique. Biomaterials. 2016.
Deng CX et al. Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation. Biomaterials. 2017.
Deng CX et al. Multimode Ultrasound Viscoelastography for Three-Dimensional Interrogation of Microscale Mechanical Properties in Heterogeneous Biomaterials. Biomaterials. 2018.
Deng CX et al. Acoustic actuation of integrin-bound microbubbles for mechanical phenotyping during differentiation and morphogenesis of human embryonic stem cells. Small. 2018.
Deng CX et al. Integrin-targeted Cyclic Forces Accelerate Neural Tube-like Rosette Formation from Human Embryonic Stem Cells. Adv Biosyst. 2019.
Deng CX et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Deng CX et al. Resonant acoustic rheometry for non-contact characterization of viscoelastic biomaterials. Biomaterials. 2021.
Deng CX et al. High Frequency Spectral Ultrasound Imaging Detects Early Heterotopic Ossification in Rodents. Stem Cells Dev. 2021.
Deng et al. Crossover of surface waves and capillary-viscous-elastic transition in soft biomaterials detected by resonant acoustic rheometry. Biomaterials. 2023.
Deng et al. Metabolic-Glycoengineering-Enabled Molecularly Specific Acoustic Tweezing Cytometry for Targeted Mechanical Stimulation of Cell Surface Sialoglycans. Angew Chem Int Ed Engl. 2024.
Deng et al. Brown Adipose Tissue as a Unique Niche for Islet Organoid Transplantation: Insights From In Vivo Imaging. Transplant Direct. 2024.
Edwards et al. Dental students’ OMFS-related experiences and interest in OMFS careers: An exploration. J Dent Educ. 2021.
Edwards et al. Squamous Cell Carcinoma of the Tongue in Young Patients: A Case Series and Literature Review. J Oral Maxillofac Surg. 2021.
Edwards et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Edwards et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Edwards et al. Clinical Practice Trends and Postoperative Outcomes in Primary Cleft Rhinoplasty. Cleft Palate Craniofac J. 2022.
Edwards et al. Resolution of mandibular fibrous dysplasia following imatinib therapy in Noonan syndrome. Pediatr Blood Cancer. 2023.
Edwards et al. Oral maxillofacial surgery resident, faculty and practitioner role models and dental students’ interest in oral maxillofacial surgery careers: Does gender matter?. J Dent Educ. 2023.
Edwards et al. Pediatric Mandibular Reconstruction. Atlas Oral Maxillofac Surg Clin North Am. 2023.
Fabiili et al. Real-time spatiotemporal characterization of mechanics and sonoporation of acoustic droplet vaporization in acoustically responsive scaffolds. Appl Phys Lett. 2023.
Fabiilli et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.
Fabiilli et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.
Fabiilli et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Fabiilli et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.
Fabiilli et al. Slow-Flow Ultrasound Localization Microscopy Using Recondensation of Perfluoropentane Nanodroplets. Ultrasound Med Biol. 2022.
Fabiilli et al. Multi-time scale characterization of acoustic droplet vaporization and payload release of phase-shift emulsions using high-speed microscopy. Ultrason Sonochem. 2022.
Fabiilli et al. Pressure Measurement in a Bladder Phantom Using Contrast-Enhanced Ultrasonography – A Path to a Catheter-Free Voiding Cystometrogram. Invest Radiol. 2023.
Fabiilli et al. Ultrasound Contrast Stability for Urinary Bladder Pressure Measurement. Ultrasound Med Biol. 2023.
Fabiilli et al. Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber Model In Vivo. Tissue Eng Part C Methods. 2024.
Fabiilli et al. The radial dynamics and acoustic emissions of phase-shift droplets are impacted by mechanical properties of tissue-mimicking hydrogels. Ultrason Sonochem. 2024.
Fabiilli et al. Acoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery. J Control Release. 2024.
Fabiilli et al. Charge balanced aggregation: A universal approach to aqueous organic nanocrystals. J Control Release. 2024.
Fabiilli ML et al. Spatiotemporally-controlled transgene expression in hydroxyapatite-fibrin composite scaffolds using high intensity focused ultrasound. Biomaterials. 2019.
Fabiilli ML et al. Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation. Acta Biomater. 2019.
Fabiilli ML et al. Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds. Ultrason Sonochem. 2020.
Fabiilli ML et al. Spatially-directed cell migration in acoustically-responsive scaffolds via the controlled delivery of basic fibroblast growth factor. Acta Biomater. 2020.
Fabiilli ML et al. Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization. Soft Matter. 2020.
Fabiilli ML et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.
Fabilli et al. Ultra-high-speed dynamics of acoustic droplet vaporization in soft biomaterials: Effects of viscoelasticity, frequency, and bulk boiling point. Ultrason Sonochem. 2024.
Franceschi et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.
Franceschi et al. Role of Runx2 in prostate development and stem cell function. Prostate. 2021.
Franceschi et al. Role of Discoidin Domain Receptor 2 in Craniofacial Bone Regeneration. J Dent Res. 2021.
Franceschi et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Franceschi et al. Expression of Beta-Catenin, Cadherins and P-Runx2 in Fibro-Osseous Lesions of the Jaw: Tissue Microarray Study. Biomolecules. 2022.
Franceschi et al. Cranial Base Synchondrosis: Chondrocytes at the Hub. Int J Mol Sci. 2022.
Franceschi et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022.
Franceschi et al. Control of Craniofacial Development by the Collagen Receptor, Discoidin Domain Receptor 2. Elife. 2023.
Franceschi et al. Acoustic droplet vaporization for on-demand modulation of microporosity in smart hydrogels. Acta Biomater. 2023.
Franceschi et al. Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells. Acta Biomater. 2023.
Franceschi et al. Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis. J Pathol. 2024.
Franceschi RT et al. Advanced BMP gene therapies for temporal and spatial control of bone regeneration. J Dent Res. 2013.
Franceschi RT et al. Discoidin Domain Receptor 2 Controls Bone Formation and Marrow Adipogenesis. J Bone Miner Res. 2016.
Franceschi RT et al. Control of the osteoblast lineage by mitogen-activated protein kinase signaling. Curr Mol Biol Rep. 2017.
Franceschi RT et al. Selective Role of Discoidin Domain Receptor 2 in Murine Temporomandibular Joint Development and Aging. J Dent Res. 2018.
Franceschi RT et al. Genetic inhibition of PPAR-gamma S112 phosphorylation reduces bone formation and stimulates marrow adipogenesis. Bone. 2018.
Franceschi RT et al. Patient perceptions of SARS-CoV-2 exposure risk and association with continuity of ophthalmic care. JAMA Opthalmol. 2021.
Franceschi RT et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.
Fu et al. Branching development of early post-implantation human embryonic-like tissues in 3D stem cell culture. Biomaterials. 2021.
Fu et al. Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation. Nano Today. 2021.
Fu et al. Elucidating the behavior of trophectoderm derivatives in mouse implantation. Dev Cell. 2022.
Fu et al. Engineering multiscale structural orders for high-fidelity embryoids and organoids. Cell Stem Cell. 2022.
Fu et al. In vitro germ cell induction from fertile and infertile monozygotic twin research participants. Cell Rep Med. 2022.
Fu et al. Modeling development using microfluidics: bridging gaps to foster fundamental and translational research. Curr Opin Genet Dev. 2023.
Fu et al. Why researchers should use human embryo models with caution. Nature. 2023.
Fu et al. A Definition of Neuromodulation and Classification of Implantable Electrical Modulation for Chronic Pain. Neuromodulation. 2024.
Fu et al. Changing the public perception of human embryology. Nat Cell Bio. 2023.
Fu et al. The role of copy number variants in the genetic architecture of common familial epilepsies. Epilepsia. 2024.
Fu et al. A patterned human neural tube model using microfluidic gradients. Nature. 2024.
Fu et al. Metabolic-Glycoengineering-Enabled Molecularly Specific Acoustic Tweezing Cytometry for Targeted Mechanical Stimulation of Cell Surface Sialoglycans. Angew Chem Int Ed Engl. 2024.
Fu et al. Toward developing human organs via embryo models and chimeras. Cell. 2024.
Fu et al. Criteria for the standardization of stem-cell-based embryo models. Nat Cell Biol. 2024.
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Fu J et al. Stem-cell-based embryo models for fundamental research and translation. Nat Mater. 2021.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Heemskerk et al. Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types. Development. 2022.
Heemskerk I Full of potential: Pluripotent stem cells for the systems biology of embryonic patterning. Dev Biol. 2020.
Heemskerk I et al. Tissue cartography: compressing bio-image data by dimensional reduction. Nat Methods. 2015.
Heemskerk I et al. Differential growth triggers mechanical feedback that elevates Hippo signaling. Proc Natl Acad Sci U S A. 2016.
Heemskerk I et al. Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells. Elife. 2019.
Heemskerk I et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Phys Biol. 2021.
Heemskert et al. The many dimensions of germline competence. Curr Opin Cell Biol. 2023.
Heemskert et al. Mapping morphogenesis and mechanics in embryo models. Nat Methods. 2023.
Kemp et al. Comparison of Outcomes of Spinal Accessory to Suprascapular Nerve Transfer Versus Nerve Grafting for Neonatal Brachial Plexus Injury. Orthopedics. 2022.
Kemp et al. The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals. J Vis Exp. 2022.
Kemp et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Kemp et al. “Decreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)”. Ann Vasc Surg. 2022.
Kemp et al. Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-Dimension, Cuff-Less Microneedle Electrode Array. Small. 2022.
Kemp et al. Pathophysiological and Neuroplastic Changes in Postamputation and Neuropathic Pain: Review of the Literature. Plast Reconstr Surg Glob Open. 2022.
Kemp et al. Ultrasound appearance of regenerative peripheral nerve interface with clinical correlation. Skeletal Radiol. 2023.
Kemp et al. Dermal Sensory Regenerative Peripheral Nerve Interface for Reestablishing Sensory Nerve Feedback in Peripheral Afferents in the Rat. Plast Reconstr Surg. 2023.
Kemp et al. Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes. J Neural Eng. 2023.
Kemp et al. Michigan special issue: 60 years of Michigan plastic surgery. Semin Plast Surg. 2024.
Kemp et al. Merging humans and neuroprosthetics through regenerative peripheral nerve interfaces. Semin Plast Surg. 2024.
Kemp SWP et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Killian et al. Overload in a Rat In Vivo Model of Synergist Ablation Induces Tendon Multiscale Structural and Functional Degeneration. J Biomech Eng. 2023.
Killian et al. Physical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels. Adv Funct Mater. 2022.
Killian et al. Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments. Dev Dyn.
Killian et al. Growth and mechanobiology of the tendon-bone enthesis. Semin Cell Dev Biol. 2022.
Killian et al. Maize brace root mechanics vary by whorl, genotype and reproductive stage. Ann Bot. 2022.
Killian et al. Targeted deletion of Fgf9 in tendon disrupts mineralization of the developing enthesis. FASEB J. 2023.
Killian et al. Overload in a Rat In Vivo Model of Synergist Ablation Induces Tendon Multiscale Structural and Functional Degeneration. J Biomech Eng. 2023.
Killian et al. Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death. Dev Dyn. 2023.
Killian et al. Equitable hiring strategies towards a diversified faculty. Nat Biomed Eng. 2023.
Killian et al. Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle. FASEB J. 2024.
Killian et al. Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice. Sci Adv. 2023.
Killian ML et al. Effects of imbalanced muscle loading on hip joint development and maturation. J Orthop Res. 2017.
Killian ML et al. Partial-width injuries of the rat rotator cuff heal with fibrosis. Connect Tissue Res. 2018.
Killian ML et al. Novel model for the induction of postnatal murine hip deformity. J Orthop Res. 2019.
Killian ML et al. Photobiomodulation does not influence maturation and mildly improves functional healing of mouse achilles tendons. J Orthop Res. 2020.
Killian ML et al. Optogenetic activation of muscle contraction in vivo. Connect Tissue Res. 2020.
Killian ML et al. Optogenetic activation of muscle contraction in vivo. Connect Tissue Res. 2021.
Kim et al. Highly sensitive and quantitative biodetection with lipid-polymer hybrid nanoparticles having organic room-temperature phosphorescence. Biosens Bioelectron. 2022.
Kohn DH et al. Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A. 2009.
Kohn DH et al. Gene delivery via DNA incorporation within a biomimetic apatite coating. Biomaterials. 2009.
Kohn DH et al. PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol. 2016.
Kohn DH et al. Dual-functioning peptides discovered by phage display increase the magnitude and specificity of BMSC attachment to mineralized biomaterials. Biomaterials. 2017.
Kohn DH et al. Cell and material-specific phage display peptides increase iPS-MSC mediated bone and vasculature formation in vivo. Adv Healthc Mater. 2019.
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