Organ Repair (liver, kidney, pancreas, etc.)

Select Publications

• Allen BL et al. Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 2014.

• Allen BL et al. Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Biol Chem. 2015.

• Allen BL et al. Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif. J Biol Chem. 2017.

• Allen BL et al. Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib. Proc Natl Acad Sci U S A. 2017.

• Allen BL et al. The Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. Development. 2020.

• Allen et al.Pancreatic Fibroblast Heterogeneity: From Development to Cancer. Cells. 2020

• Arvan et al. Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress. JCI Insight. 2021.

• Arvan et al. The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum. Diabetes. 2022.

• Arvan et al. Thyroidal Transcriptomic Profiles of Pathoadaptive Responses to Congenital Hypothyroidism in XB130 Knockout Mice. Cells. 2022.

• Arvan et al. GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. Nat Commun. 2020.

• Arvan et al. Normal and defective pathways in biogenesis and maintenance of the insulin storage pool. J Clin Invest. 2021.

• Arvan et al. Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size. JCI Insight. 2021.

• Arvan et al. Deficient endoplasmic reticulum translocon-associated protein complex limits the biosynthesis of proinsulin and insulin. Faseb J. 2021.

• Arvan et al. Thyroid hormone synthesis continues despite biallelic thyroglobulin mutation with cell death. JCI Insight 2021.

• Arvan et al. Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes. Diabetes. 2021.

• Arvan et al. Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus. Nat Rev Endocrinol. 2021.

• Arvan et al. Distinct states of proinsulin misfolding in MIDY. Cell Mol Life Sci. 2021.

• Arvan et al. XB130 Plays an Essential Role in Folliculogenesis Through Mediating Interactions Between Microfilament and Microtubule Systems in Thyrocytes. Thyroid. 2022.

• Arvan et al. The structure of natively iodinated bovine thyroglobulin. Acta Crystallogr D Struct Biol. 2021.

• Arvan et al. Erratum to: Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. (Diabetes (2021), 70, 2580–2594). Diabetes. 2022.

• Besirli et al. Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database. Eur J Ophthalmol. 2022.

• Besirli et al. Perifoveal Chorioretinal Atrophy after Subretinal Voretigene Neparvovec-rzyl for RPE65-Mediated Leber Congenital Amaurosis. Ophthalmol Retina. 2022.

• Besirli et al. Referable Macular Hemorrhage-A Clinically Meaningful Screening Target in Newborn Infants. Position Statement of the Association of Pediatric Retina Surgeons. Ophthalmic Surg Lasers Imaging Retina. 2022.

• Besirli et al. Surgical repair of primary non-complex rhegmatogenous retinal detachment in the modern era of small-gauge vitrectomy. BMJ Open Opthalmology 2021.

• Besirli et al. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis. Sci Rep. 2020.

• Besirli et al. Coats-like Exudative Vitreoretinopathy in Retinitis Pigmentosa: Ocular Manifestations and Treatment Outcomes. Opthalmol Retina. 2021.

• Besirli et al. Cryotherapy for the management of refractory hypotony secondary to post-goniotomy cyclodialysis cleft. Am J Ophthalmol Case Rep. 2020.

• Besirli et al. Novel TMEM98, MFRP, PRSS56 variants in a large United States high hyperopia and nanophthalmos cohort. Sci Rep. 2020.

• Besirli et al. A novel OCT signature in leukemic papillopathy masquerading as autoimmune or infectious uveitis. Graefes Arch Clin Exp Opthalmol. 2021.

• Besirli et al. Autophagy activation and photoreceptor survival in retinal detachment. Exp Eye Res. 2021.

• Besirli et al. Scleral Histopathologic Findings of Hurler-Scheie Syndrome with Refractory Glaucoma. JAMA Ophthalmol. 2022.

• Besirli, et al. Characteristics of Retinal Detachment after Pediatric Open-Globe Injuries. Ophthalmol Retina. 2021.

• Buttitta et al. Monitoring Spontaneous Quiescence and Asynchronous Proliferation-Quiescence Decisions in Prostate Cancer Cells. Front Cell Dev Biol. 2021.

• Buttitta LA et al. Protein Phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015.

• Buttitta LA et al. Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Biol Open. 2016.

• Buttitta LA et al. Chromatin organization changes during the establishment and maintenance of the postmitotic state. Epigenetics Chromatin. 2017.

• Buttitta LA et al. Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells. PLoS Biol. 2019.

• Buttitta LA et al. Polyploidy in the adult Drosophila brain. Elife. 2020.

• Buttitta LA et al. Abscisic acid regulates dormancy of prostate cancer disseminated tumor cells in the bone marrow. Neoplasia. 2021.

• Buttitta LA et al. The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1. Proc Natl Acad Sci U S A. 2021.

• Chandrasekaran et al. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020.

• Chandrasekaran et al. Metabolic remodelling during early mouse embryo development. Nat Metab. 2021.

• Chandrasekaran et al. Metabolic signatures of regulation by phosphorylation and acetylation. iScience. 2022.

• Chandrasekaran S et al. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016.

• Chandrasekaran S et al. Comprehensive mapping of pluripotent stem cell metabolism using dynamic genome-scale network modeling. Cell Rep. 2017.

• Chandrasekaran S et al. Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors. Genome Biol. 2019.

• Chandrasekaran S et al. Dynamic Network Modeling of Stem Cell Metabolism, Methods in Molecular Biology: Computational Stem Cell Biology. Methods Mol Biol. 2019.

• Chandrasekaran S et al. Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling. Bioessays. 2020.

• Chandrasekaran S et al. Next-generation genome-scale metabolic modeling through integration of regulatory mechanisms. Metabolites. 2021.

• Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.

• Chen YE et al. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration. Biomaterials. 2015.

• Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.

• Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.

• Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.

• Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.

• Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.

• Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.

• Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.

• Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.

• Clines et al. Osteoblasts Generate Testosterone From DHEA and Activate Androgen Signaling in Prostate Cancer Cells. J Bone Miner Res. 2021.

• Clines et al. Clinical bone health among adults with cerebral palsy: moving beyond assessing bone mineral density alone. Dev Med Child Neurol. 2022.

• Clines et al. Ca2+-independent phospholipase A2β-derived PGE2 contributes to osteogenesis. Prostaglandins Other Lipid Mediat. 2022.

• Clines GA et al. Dura promotes metastatic potential in prostate cancer through the CXCR2 pathway. J Neurooncol. 2021.

• Cohen et al. A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro. Surgery. 2021.

• Cohen et al. Early biochemical response to parathyroidectomy for primary hyperparathyroidism and its predictive value for recurrent hypercalcemia and recurrent primary hyperparathyroidism. Surgery. 2021.

• Collins CA et al. Regulation of longevity by depolarization-induced activation of PLC-β-IP 3 R signaling in neurons. Proc Natl Acad Sci U S A. 2021.

• Collins CA et al. An NAD+/NMN balancing act by SARM1 and NMNAT2 controls axonal degeneration. J Neuron. 2021.

• Duan C et al. Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc Natl Acad Sci U S A. 2010.

• Duan C et al. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 2014.

• Duan C et al. Ca2+ concentration-dependent premature death of igfbp5a mutant zebrafish reveals a critical role of IGF signaling in adaptive epithelial growth. Sci Signal. 2018.

• Duan C et al. Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. Elife. 2019.

• Duan C et al. The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. Elife. 2020.

• Duan et al. Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Front Cell Dev Biol. 2021.

• Duan et al. IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. Gen Comp Endocrinol. 2021.

• Fabiilli et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.

• Fabiilli et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.

• Fabiilli et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.

• Fabiilli et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.

• Fabiilli ML et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.

• Feldman EL et al. Diabetic neuropathy in children and youth: New and emerging risk factors. Pediatr Diabetes. 2021.

• Feldman EL et al. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron. 2021.

• Feldman EL et al. Lessons for clinical trial design in Friedreich’s ataxia. Lancet Neurol. 2021.

• Feldman EL et al. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. Faseb J. 2021.

• Feldman EL et al. Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes. Ann Clin Transl Neurol. 2021.

• Feldman EL et al. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight 2021.

• Feldman et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.

• Feldman et al. Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact. Neurosci Biobehav Rev. 2021.

• Feldman et al. Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis. JAMA Neurol. 2021.

• Feldman et al. Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology. Obesity (Silver Spring). 2021.

• Feldman et al. Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy. Dis Model Mech. 2021.

• Feldman et al. Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis. Front Immunol. 2022.

• Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.

• Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.

• Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.

• Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.

• Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.

• Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.

• Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.

• Giger RJ et al. THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes. Proc Natl Acad Sci USA. 2021.

• Goldman D et al. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci. 2006.

• Goldman D et al. Ascl1a regulates Müller glia dedifferentiation and retina regeneration via a Lin-28-dependent, let-7 miRNA signaling pathway. Nat Cell Biol. 2010.

• Goldman D et al. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012.

• Goldman D et al. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Proc Natl Acad Sci U S A. 2013.

• Goldman D et al. Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. Elife. 2020.

• Hammer GD et al. Mouse models of adrenocortical tumors. Mol Cell Endocrinol. 2016.

• Hammer GD et al. 5th International ACC Symposium: Introduction. Horm Cancer. 2016.

• Hammer GD et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016.

• Hammer GD et al. Molecular Heterogeneity in Aldosterone-Producing Adenomas. J Clin Endocrinol Metab. 2016.

• Hammer GD et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016.

• Hammer GD et al. Stem cell function and plasticity in the normal physiology of the adrenal cortex. Mol Cell Endocrinol. 2021.

• Hammer GD et al. β-catenin in adrenal zonation and disease. Mol Cell Endocrinol. 2021.

• Hammoud et al. Regulation of meiotic progression by Sertoli-cell androgen signaling. Mol Biol Cell. 2020.

• Harder JL et al. High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Cell Stem Cell. 2018.

• Harder JL et al. Organoid single cell profiling identifies a transcriptional signature of glomerular disease. JCI Insight. 2020.

• Harder JL et al. Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker. JCI Insight. 2020.

• Harder JL et al. SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease. Kidney Int. 2020.

• Heemskerk I Full of potential: Pluripotent stem cells for the systems biology of embryonic patterning. Dev Biol. 2020.

• Heemskerk I et al. Tissue cartography: compressing bio-image data by dimensional reduction. Nat Methods. 2015.

• Heemskerk I et al. Differential growth triggers mechanical feedback that elevates Hippo signaling. Proc Natl Acad Sci U S A. 2016.

• Heemskerk I et al. Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells. Elife. 2019.

• Heemskerk I et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Phys Biol. 2021.

• Herron et al. Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes. Sci Rep. 2020.

• Herron et al. In vitro model of ischemic heart failure using human induced pluripotent stem cell–derived cardiomyocytes. JCI Insight. 2021.

• Herron et al.Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations. Regul Toxicol Pharmacol. 2020

• Herron TJ Stiffness triggers non-coding RNA pathology. Nat Biomed Eng. 2019.

• Herron TJ et al. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes. J Mol Cell Cardiol. 2016.

• Herron TJ et al. hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen. Sci Rep. 2017.

• Herron TJ et al. Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors. Nat Commun. 2019.

• Herron TJ et al. Detection of Drug-Induced Torsades de Pointes Arrhythmia Mechanisms Using hiPSC-CM Syncytial Monolayers in a High-Throughput Screening Voltage Sensitive Dye Assay. Toxicol Sci. 2020.

• Kohn DH et al. Translating Dental, Oral, and Craniofacial Regenerative Medicine Innovations to the Clinic through Interdisciplinary Commercial Translation Architecture. J Dent Res. 2021.

• Kretzler et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat Commun. 2020.

• Kretzler et al. A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project. Physiol Genomics. 2021.

• Kretzler et al. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Lab Invest. 2021.

• Kretzler et al. Development and evaluation of deep learning–based segmentation of histologic structures in the kidney cortex with multiple histologic stains. Kidney Int. 2021.

• Kretzler et al.Transcriptome analysis of primary podocytes reveals novel calcium regulated regulatory networks. FASEB J. 2020

• Kruger et al. Acupressure for cancer-fatigue in ovarian cancer survivor (The AcuOva Study): A community-based clinical trial study protocol examining the impact of self-acupressure on persistent cancer related fatigue in ovarian cancer survivors. Contemp Clin Trials. 2021.

• Kruger et al. Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study. J Urol. 2022.

• Kruger et al. Reply by Authors. J Urol. 2022.

• Kushner et al. Positive charging of grains in an afterglow plasma is enhanced by ions drifting in an electric field. Phys Plasmas. 2021.

• Kushner et al. Scaling of atomic layer etching of SiO2in fluorocarbon plasmas: Transient etching and surface roughness. J. Vac. Sci. Technol. 2021.

• Kushner et al. Interactions between atmospheric pressure plasmas and metallic catalyst particles in packed bed reactors. J. Phys. D: Appl. Phys. 2021.

• Kushner et al. Electric field reversals resulting from voltage waveform tailoring in Ar/O2capacitively coupled plasmas sustained in asymmetric systems. Plasma Sources Sci. Technol. 2021.

• Kushner et al. Propagation of atmospheric pressure plasmas through interconnected pores in dielectric materials. J Appl Phys. 2021.

• Lempka et al. The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation. Neuromodulation. 2021.

• Lempka et al. Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action. J Pain. 2022.

• Lempka et al. Neural Recruitment During Conventional, Burst, and 10-kHz Spinal Cord Stimulation for Pain. J Pain. 2022.

• Lempka et al. Augmented Transcutaneous Stimulation Using an Injectable Electrode: A Computational Study. Front Bioeng Biotechnol. 2021.

• McCauley et al. Anabolic actions of PTH in murine models: two decades of insights. J Bone Miner Res. 2021.

• McCauley et al. Cross Talk Between Macrophages and Cancer Cells in the Bone Metastatic Environment. Front Endocrinol (Lausanne). 2021.

• Mehta G et al. Personalized Medicine–Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids. Clin Cancer Res. 2017.

• Mehta G et al. Integrated cancer tissue engineering models for precision medicine. PLoS One. 2019.

• Mehta G et al. Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance. Neoplasia. 2019.

• Mehta G et al. Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments. J Immunother Cancer. 2019.

• Mehta G et al. Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor. Cancers (Basel). 2020.

• Mistretta et al. The fungiform papilla is a complex, multimodal, oral sensory organ. Curr Opin Physiol. 2021.

• Mistretta et al. Probing the multimodal fungiform papilla: complex peripheral nerve endings of chorda tympani taste and mechanosensitive fibers before and after Hedgehog pathway inhibition. Cell Tissue Res. 2022.

• Mycek et al. Noninvasive Optical Assessment of Implanted Tissue-Engineered Construct Success in Situ. Tissue Eng Part C Methods. 2021.

• Nagrath D et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017.

• Nagrath D et al. Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism. Cell Metab. 2019.

• Nagrath D et al. Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours. Nat Metab. 2020.

• Nagrath D et al. Corrigendum to ‘Synthetic lethality: a step forward for personalized medicine in cancer’ [Drug Discov. Today 25 (2020) 305–320] (Drug Discovery Today (2020) 25(2) (305–320), (S1359644619304568), (10.1016/j.drudis.2019.11.014)). Drug Discov Today. 2021.

• Nagrath et al. Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma. Nat Commun. 2020.

• Nagrath et al. ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment. Nat Commun. 2020.

• Nagrath et al. Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel. Nat Biomed Eng. 2021.

• Nagrath et al. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. Sci Transl Med. 2021.

• Parent et al.Seizure-Induced Neurogenesis: 1 Out of 3 Ain’t Bad. Epilepsy Curr. 2020

• Parent JM et al. Critical roles of ɑII spectrin in brain development and epileptic encephalopathy. J Clin Invest. 2018.

• Parent JM et al. Modeling genetic epilepsies in a dish. Dev Dyn. 2020.

• Parent JM et al. Altered synaptic drive onto birthdated dentate granule cells in experimental temporal lobe epilepsy. J Neurosci. 2019.

• Parent JM et al. Multimodal analysis of STRADA function in brain Development. Front Cell Neurosci. 2020.

• Parent JM et al. Variant-Specific Changes in Persistent or Resurgent Sodium Current in SCN8A-Related Epilepsy Patient-Derived Neurons. Brain. 2020.

• Parkos CA et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med. 2007.

• Parkos CA et al. Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis. Immunity. 2012.

• Parkos CA et al. Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation. Mucosal Immunol. 2014.

• Parkos CA et al. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nat Commun. 2019.

• Parkos CA et al. Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal Immunol. 2020.

• Parkos CA et al. Dysregulation of intestinal epithelial CFTR-dependent Cl− ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice. Mucosal Ummunol. 2021.

• Putnam AJ et al. Resonant acoustic rheometry for non-contact characterization of viscoelastic biomaterials. Biomaterials. 2021.

• Putnam AJ et al. Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform. Lab Chip. 2021.

• Putnam et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.

• Putnam et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.

• Putnam et al. Phenotypic, trophic, and regenerative properties of mesenchymal stem cells from different osseous tissues. Cell Tissue Res. 2022.

• Putnam, et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.

• Rajapakse I et al. On Emerging Nuclear order. J Cell Biol. 2011.

• Rajapakse I et al. Dynamics and control of state-dependent networks for probing genomic organization. Proc Natl Acad Sci U S A. 2011.

• Rajapakse I et al. Functional organization of the human 4D Nucleome. Proc Natl Acad Sci U S A. 2015.

• Rajapakse I et al. Emergence of function from coordinated cells in a tissue. Proc Natl Acad Sci U S A. 2017.

• Rajapakse I et al. An Algorithm for Cellular Reprogramming. Proc Natl Acad Sci U S A. 2017.

• Rao et al. Assessing patient perception of risk in ocular stem cell therapies. Stem Cell Reports. 2021.

• Rao et al. p53 inactivation unmasks histone methylation-independent WDR5 functions that drive self-renewal and differentiation of pluripotent stem cells. Stem Cell Reports. 2021.

• Rao RC et al. Ubiquitous Chromatin Modifiers in Congenital Retinal Diseases: Implications for Disease Modeling and Regenerative Medicine. Trends Mol Med. 2021.

• Rao RC et al. Research Funding, Income, and Career Satisfaction Among Clinician-Scientists in Ophthalmology in the United States. Am J Ophthalmol. 2021.

• Rao RC et al. Molecular characterization of a rare case of bilateral vitreoretinal t cell lymphoma through vitreous liquid biopsy. Int J Mol Sci. 2021.

• Rao RC et al. Retinal haemorrhage as a complication of blastic plasmacytoid dendritic cell neoplasm. Lancet Haematol. 2021.

• Rao RC et al. Comparative molecular analysis of primary central nervous system lymphomas and matched vitreoretinal lymphomas by vitreous liquid biopsy. Int J Mol Sci. 2021.

• Ross et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem 2022.

• Rui et al. Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020.

• Rui L et al. Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun. 2018.

• Rui L et al. Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice. J Clin Invest. 2019.

• Rui L et al. Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKŒ± pathway shapes autoimmunity and liver and lung homeostasis in mice. Proc Natl Acad Sci U S A. 2019.

• Rui L et al. Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020.

• Rui L et al. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. J Clin Invest. 2020.

• Samuelson et al.A year of challenge and change. Physiology (Bethesda). 2020

• Samuelson LC et al. Notch Signaling Modulates Proliferation and Differentiation of Intestinal Crypt Base Columnar Stem Cells. Development. 2012.

• Samuelson LC et al. Notch Signaling Regulates Gastric Antral LGR5 Stem Cell Function. EMBO J. 2015.

• Samuelson LC et al. Genome toxicity and impaired stem cell function after conditional activation of CreERT2 in the intestine. Stem Cell Reports. 2018.

• Samuelson LC et al. Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response after Irradiation Injury. Cell Mol Gastroenterol Hepatol. 2020.

• Samuelson LC et al. Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition. Stem Cell Reports. 2020.

• Scott et al. Iridium-Catalysed C−H Borylation of Heteroarenes: Balancing Steric and Electronic Regiocontrol. Angew Chem Int Ed Engl. 2021.

• Scott et al. On the consensus nomenclature rules for radiopharmaceutical chemistry – Reconsideration of radiochemical conversion. Nucl Med Biol. 2021.

• Scott et al. An updated synthesis of N1′-([11C]methyl)naltrindole for positron emission tomography imaging of the delta opioid receptor. J Labelled Comp Radiopharm. 2021.

• Scott et al. Radiofluorination of oxazole-carboxamides for preclinical PET neuroimaging of GSK-3. J Fluor Chem. 2021.

• Scott et al. A Comprehensive Assessment of 68Ga-PSMA-11 PET in Biochemically Recurrent Prostate Cancer: Results from a Prospective Multicenter Study on 2,005 Patients. J Nucl Med. 2022.

• Scott et al. Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971. Eur J Nucl Med Mol Imaging. 2021.

• Scott et al. Potential Applications of Artificial Intelligence and Machine Learning in Radiochemistry and Radiochemical Engineering. PET Clin. 2021.

• Scott et al. Preliminary Evaluations of [11C]Verubulin: Implications for Microtubule Imaging With PET. Front Neurosci. 2021.

• Scott et al. Nuclear Medicine and Artificial Intelligence: Best Practices for Algorithm Development. J Nucl Med. 2022.

• Scott et al. Synthesis and Evaluation of a Fluorine-18 Radioligand for Imaging Huntingtin Aggregates by Positron Emission Tomographic Imaging. Front Neurosci. 2021.

• Scott et al. Synthesis of 68Ga-radiopharmaceuticals using both generator-derived and cyclotron-produced 68Ga as exemplified by [68Ga]Ga-PSMA-11 for prostate cancer PET imaging. Nat Protoc. 2022.

• Scott et al. No Dopamine Agonist Modulation of Brain [18F]FEOBV Binding in Parkinson’s Disease. Mol Pharm. 2022.

• Smith et al. Mouse oocyte vitrification with and without dimethyl sulfoxide: influence on cryo-survival, development, and maternal imprinted gene expression. J Assist Reprod Genet. 2021.

• Smith et al. Microfluidic systems for isolation of spermatozoa from testicular specimens of non-obstructive azoospermic men: Does/can it improve sperm yield?. J Clin Med. 2021.

• Smith et al. The Future of IVF: The New Normal in Human Reproduction. Reprod Sci. 2022.

• Smith et al. Non-invasive oocyte quality assessment. Biol Reprod. 2022.

• Soleimanpour SA et al. The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?. Trends Endocrinol Metab. 2013.

• Soleimanpour SA et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014.

• Soleimanpour SA et al. Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in beta cells. Diabetes. 2015.

• Soleimanpour SA et al. Clec16a, Nrdp1, and USP8 form a ubiquitin-dependent tripartite complex that regulates beta cell mitophagy. Diabetes. 2018.

• Soleimanpour SA et al. The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic beta cells and adipocytes. J Biol Chem. 2019.

• Spence et al. Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung. Stem Cells Transl Med. 2021.

• Spence et al. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2021.

• Spence et al. Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model. Nucleic Acids Res. 2021.

• Spence et al.The Lumen of Human Intestinal Organoids Poses Greater Stress to Bacteria Compared to the Germ-Free Mouse Intestine: Escherichia coli Deficient in RpoS as a Colonization Probe. mSphere. 2020

• Spence et al.Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures. Front Cell Dev Biol. 2020

• Stegemann et al. Aseptic and septic prosthetic joint loosening: Impact of biomaterial wear on immune cell function, inflammation, and infection. Biomaterials. 2021.

• Stegemann et al. Controlled growth factor delivery and cyclic stretch induces a smooth muscle cell-like phenotype in adipose-derived stem cells. Cells. 2021.

• Stegemann JP et al. Resonant acoustic rheometry for non-contact characterization of viscoelastic biomaterials. Biomaterials. 2021.

• Wang et al. The psychobiological links between chronic stress-related diseases, periodontal/peri-implant diseases, and wound healing. Periodontol 2000. 2021.

• Wang et al. Digital fixed complete-arch rehabilitation: From virtual articulator mounting to clinical delivery. J Prosthet Dent. 2022.

• Wang et al. Dual Digitally Guided Crown Lengthening in Esthetic Area Compromised by Disharmonic Implant Crown. Clin Adv Periodontics. 2022.

• Wang et al. Trueness and Precision of Economical Smartphone-Based Virtual Facebow Records. J Prosthodont. 2022.

• Wang et al. Resolution of peri-implantitis by means of implantoplasty as adjunct to surgical therapy: A retrospective study. J Periodontol. 2022.

• Wang et al. Long term comparison of the prognostic performance of PerioRisk, periodontal risk assessment, periodontal risk calculator, and staging and grading systems. J Periodontol. 2022.

• Wang et al. Three-Dimensional Cell Printed Lock-Key Structure for Oral Soft and Hard Tissue Regeneration. Tissue Eng Part A. 2022.

• Wang et al. Prognostic performance of the 2017 World Workshop classification on staging and grading of periodontitis compared with the British Society of Periodontology’s implementation. J Periodontol. 2022.

• Wang et al. External validation and comparison of the predictive performance of 10 different tooth-level prognostic systems. J Clin Periodontol. 2021.

• Wang et al. Agreement among international periodontal experts using the 2017 World Workshop classification of periodontitis. J Periodontol. 2021.

• Wang et al. Intraoral scanning reduces procedure time and improves patient comfort in fixed prosthodontics and implant dentistry: a systematic review. Clin Oral Investig. 2021.

• Wang et al. Risk of early implant failure in grafted and non-grafted sites: A systematic review and meta-analysis. Int J Oral Implantol (Berl). 2022.

• Wang et al. Prognostic factors associated with implant loss, disease progression or favorable outcomes after peri-implantitis surgical therapy. Clin Implant Dent Relat Res. 2022.

• Wang H-L et al. Creating a virtual patient for completely edentulous computer-aided implant surgery: A dental technique. J Prosthet Dent. 2021.

• Wang H-L et al. Influence of bone density, drill diameter, drilling speed, and irrigation on temperature changes during implant osteotomies: an in vitro study. Clin Oral Investig. 2021.

• Wang H-L et al. Suppuration as diagnostic criterium of peri-implantitis. J Periodontol. 2021.

• Wang H-L et al. Acellular dermal matrix for root coverage procedures: 9-year assessment of treated isolated gingival recessions and their adjacent untreated sites. J Periodontol. 2021.

• Wang H-L et al. Laser-assisted regenerative surgical therapy for peri-implantitis: A randomized controlled clinical trial. J Periodontol. 2021.

• Wang H-L et al. Indirect Digital Workflow for Virtual Cross-Mounting of Fixed Implant-Supported Prostheses to Create a 3D Virtual Patient. J Prosthodont. 2021.

• Wang H-L et al. Influence of restorative design on the progression of peri-implant bone loss: A retrospective study. J Periodontol. 2021.

• Wang H-L et al. The influence of the interaction between staging, grading and extent on tooth loss due to periodontitis. J Clin Periodontol. 2021.

• Wang H-L et al. Intra-osseous heat generation during implant bed preparation with static navigation: Multi-factor in vitro study. Clin Oral Implants Res. 2021.

• Wang H-L et al. Treatment of periimplantitis with electrolytic cleaning versus mechanical and electrolytic cleaning: 18-month results from a randomized controlled clinical trial. J Clin Med. 2021.

• Wang HL et al. Efficacy of platelet-rich fibrin on socket healing after mandibular third molar extractions. J Oral and Maxillofac Surg. 2021.

• Yang B et al. Surgical explantation of transcatheter aortic bioprostheses: Results and clinical implications. J Thorac Cardiovasc Surg. 2021.

• Yang B et al. Type A Aortic Dissection With Cerebral Malperfusion: New Insights. Ann Thorac Surg. 2021.

• Yang B et al. Reply from the author: respect mother nature-aortic root repair in acute type A aortic dissection. J Thorac Cardiovasc Surg. 2021.

• Yang B et al. Reduced Echocardiographic Inotropy Index after Cardiopulmonary Bypass Is Associated With Complications After Cardiac Surgery: An Institutional Outcomes Study. J Cardiothorac Vasc Anesth. 2021.

• Yang B et al. A Y Incision and Rectangular Patch to Enlarge the Aortic Annulus by Three Valve Sizes. Ann Thorac Surg. 2021.

• Yang B et al. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021.

• Yang B. et al. Impact of Chronic Renal Failure on Surgical Outcomes in Patients With Infective Endocarditis. Ann Thorac Surg. 2021.

• Yang B. et al. Is hemiarch replacement adequate in acute type A aortic dissection repair in patients with arch branch vessel dissection without cerebral malperfusion?. J Thorac Cardiovasc Surg. 2021.

• Yang B. et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.

• Yang et al. Root abscess in the setting of infectious endocarditis: Short- and long-term outcomes. J Thorac Cardiovasc Surg. 2021.

• Yang et al. Gait speed is a preoperative indicator of postoperative events after elective proximal aortic surgery. J Thorac Cardiovasc Surg. 2022.

• Yang et al. Aortic progression and reintervention in patients with pathogenic variants after a thoracic aortic dissection. J Thorac Cardiovasc Surg. 2021.

• Yang et al. Commentary: Does the STABILISE technique stabilize the aneurysm in chronic dissection?. J Thorac Cardiovasc Surg. 2021.

• Yang et al. Surgical Explantation of Transcatheter Aortic Bioprostheses: Balloon vs Self-Expandable Devices. Ann Thorac Surg. 2022.

• Yang et al. The Clinical Impact of Implementation of a Multidisciplinary Endocarditis Team. Ann Thorac Surg. 2022.

• Yang et al. Open Repair of Aortic Arch Mycotic Pseudoaneurysms With Distal Perfusion. Ann Thorac Surg. 2022.

• Zemans et al. Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and proinflammatory immune reprogramming. Am J Physiol Lung Cell Mol Physiol. 2021.

• Zopf DA et al. Bioresorbable airway splint created with a three-dimensional printer. N Engl J Med. 2013.

• Zopf DA et al. Computer aided-designed, 3-dimensionally printed porous tissue bioscaffolds for craniofacial soft tissue reconstruction. Otolaryngol Head Neck Surg. 2014.

• Zopf DA et al. A multidisciplinary international collaborative implementing low cost, high fidelity 3D printed airway models to enhance Ethiopian anesthesia resident emergency cricothyroidotomy skills. Int J Pediatr Otorhinolaryngol. 2018.

• Zopf DA et al. Anatomic-Based Design, Manufacturing, and Preclinical Assessment of a Novel 3D-Printed Bioscaffold for Total Nasal Reconstruction. Facial Plast Surg Aesthet Med. 2020.

• Zopf DA et al. Multi-institutional Comparison of Temporal Bone Models: A Collaboration of the AAO-HNSF 3D-Printed Temporal Bone Working Group. Otolaryngol Head Neck Surg. 2021.

• Zopf DA et al. Hybrid Three-Dimensional-Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications. Laryngoscope. 2020.

• Zopf et al. Preclinical assessment of clinically streamlined, 3D-printed, biocompatible single- and two-stage tissue scaffolds for ear reconstruction. J Biomed Mater Res B Appl Biomater. 2021.

• Zopf et al. Development of a novel mandibular distraction osteogenesis simulator using Computer Aided Design and 3D printing. Int J Pediatr Otorhinolaryngol. 2021.

• Zopf et al. Adoption of Telemedicine for Multidisciplinary Care in Pediatric Otolaryngology. Ann Otol Rhinol Laryngol. 2021.

• Zopf et al. Early preclinical evaluation of a novel, computer aided designed, 3D printed, bioresorbable posterior cricoid scaffold. Int J Pediatr Otorhinolaryngol. 2021.

• Zopf et al. Starting a medical 3D printing lab for otolaryngology-head and neck surgery collaboration. Am J Otolaryngol. 2022.