Organ Repair (liver, kidney, pancreas, etc.)

Select Publications

• Allen BL et al. Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 2014.

• Allen BL et al. Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Biol Chem. 2015.

• Allen BL et al. Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif. J Biol Chem. 2017.

• Allen BL et al. Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib. Proc Natl Acad Sci U S A. 2017.

• Allen BL et al. The Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. Development. 2020.

• Allen et al.Pancreatic Fibroblast Heterogeneity: From Development to Cancer. Cells. 2020

• Arvan et al. Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress. JCI Insight. 2021.

• Arvan et al. The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum. Diabetes. 2022.

• Arvan et al. Thyroidal Transcriptomic Profiles of Pathoadaptive Responses to Congenital Hypothyroidism in XB130 Knockout Mice. Cells. 2022.

• Arvan et al. GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. Nat Commun. 2020.

• Arvan et al. Normal and defective pathways in biogenesis and maintenance of the insulin storage pool. J Clin Invest. 2021.

• Arvan et al. Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size. JCI Insight. 2021.

• Arvan et al. Deficient endoplasmic reticulum translocon-associated protein complex limits the biosynthesis of proinsulin and insulin. Faseb J. 2021.

• Arvan et al. Thyroid hormone synthesis continues despite biallelic thyroglobulin mutation with cell death. JCI Insight 2021.

• Arvan et al. Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes. Diabetes. 2021.

• Arvan et al. Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus. Nat Rev Endocrinol. 2021.

• Arvan et al. Distinct states of proinsulin misfolding in MIDY. Cell Mol Life Sci. 2021.

• Arvan et al. XB130 Plays an Essential Role in Folliculogenesis Through Mediating Interactions Between Microfilament and Microtubule Systems in Thyrocytes. Thyroid. 2022.

• Arvan et al. The structure of natively iodinated bovine thyroglobulin. Acta Crystallogr D Struct Biol. 2021.

• Arvan et al. Erratum to: Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. (Diabetes (2021), 70, 2580–2594). Diabetes. 2022.

• Arvan et al. Maintaining the thyroid gland in mutant thyroglobulin–induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood. J Biol Chem. 2022.

• Arvan et al. Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity. Diabetes. 2022.

• Arvan et al. Proteasomal degradation of WT proinsulin in pancreatic beta cells. J Biol Chem. 2022.

• Arvan et al. IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cells. Proc Natl Acad Sci U S A. 2022.

• Arvan et al. Integration of ER protein quality-control mechanisms defines β cell function and ER architecture. J Clin Invest. 2023.

• Arvan et al. Defective Thyroglobulin: Cell Biology of Disease. Int J Mol Sci. 2022.

• Arvan et al. Nutrient-dependent regulation of β-cell proinsulin content. J Biol Chem. 2023.

• Arvan et al. Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland. JCI Insight. 2023.

• Arvan et al. SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells. Diabetologia. 2023.

• Arvan et al. Structural features of thyroglobulin linked to protein trafficking. Protein Sci. 2023.

• Arvan et al. Autophagy of the ER: the secretome finds the lysosome. FEBS J. 2023.

• Arvan et al. Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity. Mol Metab. 2024.

• Arvan et al. Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis. Protein Sci. 2024.

• Arvan et al. Upregulation of ryanodine receptor 1 is involved in ER stress-induced disruption of beta cell calcium homeostasis. Biophys J. 2023.

• Besirli et al. Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database. Eur J Ophthalmol. 2022.

• Besirli et al. Perifoveal Chorioretinal Atrophy after Subretinal Voretigene Neparvovec-rzyl for RPE65-Mediated Leber Congenital Amaurosis. Ophthalmol Retina. 2022.

• Besirli et al. Referable Macular Hemorrhage-A Clinically Meaningful Screening Target in Newborn Infants. Position Statement of the Association of Pediatric Retina Surgeons. Ophthalmic Surg Lasers Imaging Retina. 2022.

• Besirli et al. Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration. Nanomedicine. 2022.

• Besirli et al. Surgical repair of primary non-complex rhegmatogenous retinal detachment in the modern era of small-gauge vitrectomy. BMJ Open Opthalmology 2021.

• Besirli et al. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis. Sci Rep. 2020.

• Besirli et al. Coats-like Exudative Vitreoretinopathy in Retinitis Pigmentosa: Ocular Manifestations and Treatment Outcomes. Opthalmol Retina. 2021.

• Besirli et al. Cryotherapy for the management of refractory hypotony secondary to post-goniotomy cyclodialysis cleft. Am J Ophthalmol Case Rep. 2020.

• Besirli et al. Novel TMEM98, MFRP, PRSS56 variants in a large United States high hyperopia and nanophthalmos cohort. Sci Rep. 2020.

• Besirli et al. A novel OCT signature in leukemic papillopathy masquerading as autoimmune or infectious uveitis. Graefes Arch Clin Exp Opthalmol. 2021.

• Besirli et al. Autophagy activation and photoreceptor survival in retinal detachment. Exp Eye Res. 2021.

• Besirli et al. Outcomes of Baerveldt Glaucoma Drainage Devices in Pediatric Eyes. J Glaucoma. 2022.

• Besirli et al. Real-world outcomes of voretigene neparvovec treatment in pediatric patients with RPE65-associated Leber congenital amaurosis. Graefes Arch Clin Exp Ophthalmol. 2022.

• Besirli et al. Scleral Histopathologic Findings of Hurler-Scheie Syndrome with Refractory Glaucoma. JAMA Ophthalmol. 2022.

• Besirli et al. Late Vitreoretinal Complications of Regressed Retinopathy of Prematurity: Retinal Break, Vitreous Hemorrhage, and Retinal Detachment. Ophthalmol Retina. 2023.

• Besirli et al. Practice Patterns and Outcomes of Intravitreal Anti-VEGF Injection for Retinopathy of Prematurity: An International Multicenter Study. Ophthalmology. 2022.

• Besirli et al. A Caveat About Financial Incentives for Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Retinopathy. Am J Ophthalmol. 2022.

• Besirli et al. COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM AT PEDIATRIC AGE: Surgical Versus Conservative Approach. Retina. 2023.

• Besirli et al. Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity: A Multicenter Study. Ophthalmology. 2023.

• Besirli et al. Retinal Neovascularization in Posterior Polar Annular Choroidal Dystrophy. JAMA Ophthalmol. 2023.

• Besirli et al. Scleral Windows in the Treatment of Uveal Effusion Syndrome. Ophthalmic Surg Lasers Imaging Retina. 2022.

• Besirli et al. Quantitative analysis of tear angiogenic factors in retinopathy of prematurity: a pilot biomarker study. J AAPOS. 2023.

• Besirli et al. The impact of the COVID-19 lockdown on retinopathy of prematurity screening and management in the United States: a multicenter study. J AAPOS. 2023.

• Besirli et al. First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children With CNGB3-associated Achromatopsia. Am J Ophthalmol. 2023.

• Besirli et al. Flow cytometric method for the detection and quantification of retinal cell death and oxidative stress. Exp Eye Res. 2023.

• Besirli et al. Cataractous remnants form a free-floating cystic structure in a unicameral pediatric eye. Am J Ophthalmol Case Rep. 2023.

• Besirli et al. Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration. Cells. 2023.

• Besirli et al. Phase 1/2 AAV5-hRKp.RPGR (Botaretigene Sparoparvovec) Gene Therapy: Safety and Efficacy in RPGR-Associated X-Linked Retinitis Pigmentosa. Am J Ophthalmol. 2024.

• Besirli, et al. Characteristics of Retinal Detachment after Pediatric Open-Globe Injuries. Ophthalmol Retina. 2021.

• Buttitta et al. Monitoring Spontaneous Quiescence and Asynchronous Proliferation-Quiescence Decisions in Prostate Cancer Cells. Front Cell Dev Biol. 2021.

• Buttitta et al. Developing Future Biologists: developmental biology for undergraduates from underserved communities. Development. 2023.

• Buttitta et al. HER2 as a potential therapeutic target on quiescent prostate cancer cells. Transl Oncol. 2023.

• Buttitta et al. Transcriptional repression and enhancer decommissioning silence cell cycle genes in postmitotic tissues. G3 (Bethesda). 2024.

• Buttitta LA et al. Protein Phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015.

• Buttitta LA et al. Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Biol Open. 2016.

• Buttitta LA et al. Chromatin organization changes during the establishment and maintenance of the postmitotic state. Epigenetics Chromatin. 2017.

• Buttitta LA et al. Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells. PLoS Biol. 2019.

• Buttitta LA et al. Polyploidy in the adult Drosophila brain. Elife. 2020.

• Buttitta LA et al. Abscisic acid regulates dormancy of prostate cancer disseminated tumor cells in the bone marrow. Neoplasia. 2021.

• Buttitta LA et al. The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1. Proc Natl Acad Sci U S A. 2021.

• Chandrasekaran et al. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020.

• Chandrasekaran et al. Metabolic remodelling during early mouse embryo development. Nat Metab. 2021.

• Chandrasekaran et al. Metabolic signatures of regulation by phosphorylation and acetylation. iScience. 2022.

• Chandrasekaran et al. Machine learning to design antimicrobial combination therapies: Promises and pitfalls. Drug Discov Today. 2022.

• Chandrasekaran et al. TaxiBGC: a Taxonomy-Guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters and Secondary Metabolite Production Potential in Metagenomes. mSystems. 2022.

• Chandrasekaran et al. Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance. iScience. 2023.

• Chandrasekaran et al. Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis. iScience. 2024.

• Chandrasekaran S et al. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016.

• Chandrasekaran S et al. Comprehensive mapping of pluripotent stem cell metabolism using dynamic genome-scale network modeling. Cell Rep. 2017.

• Chandrasekaran S et al. Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors. Genome Biol. 2019.

• Chandrasekaran S et al. Dynamic Network Modeling of Stem Cell Metabolism, Methods in Molecular Biology: Computational Stem Cell Biology. Methods Mol Biol. 2019.

• Chandrasekaran S et al. Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling. Bioessays. 2020.

• Chandrasekaran S et al. Next-generation genome-scale metabolic modeling through integration of regulatory mechanisms. Metabolites. 2021.

• Chandrasekran et al. Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer. Clin Exp Metastasis. 2022.

• Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.

• Chen YE et al. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration. Biomaterials. 2015.

• Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.

• Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.

• Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.

• Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.

• Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.

• Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.

• Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.

• Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.

• Clines et al. Osteoblasts Generate Testosterone From DHEA and Activate Androgen Signaling in Prostate Cancer Cells. J Bone Miner Res. 2021.

• Clines et al. Clinical bone health among adults with cerebral palsy: moving beyond assessing bone mineral density alone. Dev Med Child Neurol. 2022.

• Clines et al. Ca2+-independent phospholipase A2β-derived PGE2 contributes to osteogenesis. Prostaglandins Other Lipid Mediat. 2022.

• Clines et al. Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2023.

• Clines et al. Perspective: A multi-trait integrative approach to understanding the structural basis of bone fragility for pediatric conditions associated with abnormal bone development. Bone. 2023.

• Clines GA et al. Dura promotes metastatic potential in prostate cancer through the CXCR2 pathway. J Neurooncol. 2021.

• Cohen et al. A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro. Surgery. 2021.

• Cohen et al. Early biochemical response to parathyroidectomy for primary hyperparathyroidism and its predictive value for recurrent hypercalcemia and recurrent primary hyperparathyroidism. Surgery. 2021.

• Collins CA et al. Regulation of longevity by depolarization-induced activation of PLC-β-IP 3 R signaling in neurons. Proc Natl Acad Sci U S A. 2021.

• Collins CA et al. An NAD+/NMN balancing act by SARM1 and NMNAT2 controls axonal degeneration. J Neuron. 2021.

• Collins et al. DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses. Cell Rep. 2024.

• Duan C et al. Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc Natl Acad Sci U S A. 2010.

• Duan C et al. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 2014.

• Duan C et al. Ca2+ concentration-dependent premature death of igfbp5a mutant zebrafish reveals a critical role of IGF signaling in adaptive epithelial growth. Sci Signal. 2018.

• Duan C et al. Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. Elife. 2019.

• Duan C et al. The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. Elife. 2020.

• Duan et al. Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Front Cell Dev Biol. 2021.

• Duan et al. IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. Gen Comp Endocrinol. 2021.

• Duan et al. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Proc Natl Acad Sci U S A. 2023.

• Fabiili et al. Real-time spatiotemporal characterization of mechanics and sonoporation of acoustic droplet vaporization in acoustically responsive scaffolds. Appl Phys Lett. 2023.

• Fabiilli et al. Release of basic fibroblast growth factor from acoustically-responsive scaffolds promotes therapeutic angiogenesis in the hind limb ischemia model. J Control Release. 2021.

• Fabiilli et al. Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds. Acta Biomater. 2021.

• Fabiilli et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.

• Fabiilli et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.

• Fabiilli et al. Slow-Flow Ultrasound Localization Microscopy Using Recondensation of Perfluoropentane Nanodroplets. Ultrasound Med Biol. 2022.

• Fabiilli et al. Multi-time scale characterization of acoustic droplet vaporization and payload release of phase-shift emulsions using high-speed microscopy. Ultrason Sonochem. 2022.

• Fabiilli et al. Pressure Measurement in a Bladder Phantom Using Contrast-Enhanced Ultrasonography – A Path to a Catheter-Free Voiding Cystometrogram. Invest Radiol. 2023.

• Fabiilli et al. Ultrasound Contrast Stability for Urinary Bladder Pressure Measurement. Ultrasound Med Biol. 2023.

• Fabiilli et al. Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber Model In Vivo. Tissue Eng Part C Methods. 2024.

• Fabiilli et al. The radial dynamics and acoustic emissions of phase-shift droplets are impacted by mechanical properties of tissue-mimicking hydrogels. Ultrason Sonochem. 2024.

• Fabiilli et al. Acoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery. J Control Release. 2024.

• Fabiilli et al. Charge balanced aggregation: A universal approach to aqueous organic nanocrystals. J Control Release. 2024.

• Fabiilli ML et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.

• Fabilli et al. Ultra-high-speed dynamics of acoustic droplet vaporization in soft biomaterials: Effects of viscoelasticity, frequency, and bulk boiling point. Ultrason Sonochem. 2024.

• Feldman EL et al. Diabetic neuropathy in children and youth: New and emerging risk factors. Pediatr Diabetes. 2021.

• Feldman EL et al. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron. 2021.

• Feldman EL et al. Lessons for clinical trial design in Friedreich’s ataxia. Lancet Neurol. 2021.

• Feldman EL et al. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. Faseb J. 2021.

• Feldman EL et al. Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes. Ann Clin Transl Neurol. 2021.

• Feldman EL et al. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight 2021.

• Feldman et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.

• Feldman et al. Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact. Neurosci Biobehav Rev. 2021.

• Feldman et al. Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis. JAMA Neurol. 2021.

• Feldman et al. Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology. Obesity (Silver Spring). 2021.

• Feldman et al. Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy. Dis Model Mech. 2021.

• Feldman et al. Nox, Nox, Are You There? the Role of NADPH Oxidases in the Peripheral Nervous System. Antioxid Redox Signal. 2022.

• Feldman et al. Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts. Brain. 2022.

• Feldman et al. A Role for Fatty Acids in Peripheral Neuropathy Associated with Type 2 Diabetes and Prediabetes. Antioxid Redox Signal. 2022.

• Feldman et al. Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis. Front Immunol. 2022.

• Feldman et al. Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. Lancet Neurol. 2022.

• Feldman et al. Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis. Lancet Neurol. 2022.

• Feldman et al. Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infection. Neurobiol Dis. 2022.

• Feldman et al. Glial-neuron crosstalk in health and disease: A focus on metabolism, obesity, and cognitive impairment. Neurobiok Dis. 2022.

• Feldman et al. Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes. Ann Clin Transl Neurol. 2022.

• Feldman et al. The Impact of the COVID-19 Pandemic on Ethnic Minority Groups With Diabetes. Diabetes Care. 2023.

• Feldman et al. Amyotrophic lateral sclerosis from genotoxins alone? – Authors’ reply. Lancet Neurol. 2022.

• Feldman et al. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments. Lancet Neurol. 2022.

• Feldman et al. miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis. Hum Mol Genet. 2023.

• Feldman et al. Diabetes and dementia: Clinical perspective, innovation, knowledge gaps. J Diabetes Complications. 2022.

• Feldman et al. The conundrum of diabetic neuropathies—Past, present, and future. J Diabetes Complications. 2022.

• Feldman et al. Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles. Muscle Nerve. 2023.

• Feldman et al. Patient and health care provider knowledge of diabetes and diabetic microvascular complications: a comprehensive literature review. Rev Endocr Metab Disord. 2023.

• Feldman et al. ISPAD Clinical Practice Consensus Guidelines 2022: Microvascular and macrovascular complications in children and adolescents with diabetes. Pediatr Diabetes. 2022.

• Feldman et al. Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice. Immun Ageing. 2022.

• Feldman et al. Disrupted axon-glia communication leads to neurodegeneration in metabolic diseases. Neurobiol Dis. 2023.

• Feldman et al. A roadmap to ALS prevention: Strategies and priorities. J Neurol Neurosurg Psychiatry. 2023.

• Feldman et al. The determinants of complication trajectories in American Indians with type 2 diabetes. JCI Insight. 2023.

• Feldman et al. Treatment-induced neuropathy of diabetes: an underdiagnosed entity – Authors’ reply. Lancet Neurol. 2023.

• Feldman et al. Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity. iScience. 2023.

• Feldman et al. The effect of surgical weight loss on diabetes complications in individuals with class II/III obesity. Diabetologia. 2023.

• Feldman et al. Advances in diagnosis and management of distal sensory polyneuropathies. J Neurol Neurosurg Psychitry. 2023.

• Feldman et al. New perspectives in diabetic neuropathy. Neuron. 2023.

• Feldman et al. Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells. Ann Clin Transl Neurol. 2023.

• Feldman et al. Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination. J Neurochem. 2023.

• Feldman et al. Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementias. Cell Genom. 2023.

• Feldman et al. Association between brain health outcomes and metabolic risk factors in persons with diabetes. Ann Clin Transl Neurol. 2023.

• Feldman et al. The amyotrophic lateral sclerosis exposome: recent advances and future directions. Nat Rev Neurol. 2023.

• Feldman et al. Gut microbiome correlates with plasma lipids in amyotrophic lateral sclerosis. Brain. 2024.

• Feldman et al. Cost and utilization of healthcare services for persons with diabetes. Diabetes Res Clin Pract. 2023.

• Feldman et al. Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer’s disease. J Extracell Vesicles. 2023.

• Feldman et al. Non-invasive in vivo measurements of metabolic alterations in the type 2 diabetic brain by 1H magnetic resonance spectroscopy. J Neurochem. 2024.

• Feldman et al. The Effect of Surgical Weight Loss on Cognition in Individuals with Class II/III Obesity. J Nutr Health Aging. 2023.

• Feldman et al. Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study. J Neurol Sci. 2024.

• Feldman et al. Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions. Ann Neurol. 2024.

• Feldman et al. Professional Experiences and Career Trajectories of Mid- to Senior-Career Women Clinician-Scientists: A Qualitative Study. JAMA Netw Open. 2024.

• Feldman et al. Peripheral Immune Profiles Predict ALS Progression in an Age- and Sex-Dependent Manner. Neurol Neuroimmunol Neuroinflamm. 2024.

• Feldman et al. Prevalence and Risk Factors of Distal Symmetric Polyneuropathy Among Predominantly Non-Hispanic Black, Low-Income Patients. Neurology. 2024.

• Feldman et al. Indirect effects of the COVID-19 pandemic on diagnosing, monitoring, and prescribing in people with diabetes and strategies for diabetes service recovery internationally. Diabetes Res Clin Pract. 2024.

• Feldman et al. High-Intensity Interval Training, Caloric Restriction, or Their Combination Have Beneficial Effects on Metabolically Acquired Peripheral Neuropathy. Diabetes. 2024.

• Feldman et al. Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank. J Neurol. 2024.

• Feldman et al. Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis. EBioMedicine. 2024.

• Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.

• Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.

• Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.

• Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.

• Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.

• Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.

• Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.

• Giger et al. DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses. Cell Rep. 2024.

• Giger et al. Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration. Cell Rep. 2024.

• Giger RJ et al. THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes. Proc Natl Acad Sci USA. 2021.

• Goldman D et al. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci. 2006.

• Goldman D et al. Ascl1a regulates Müller glia dedifferentiation and retina regeneration via a Lin-28-dependent, let-7 miRNA signaling pathway. Nat Cell Biol. 2010.

• Goldman D et al. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012.

• Goldman D et al. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Proc Natl Acad Sci U S A. 2013.

• Goldman D et al. Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. Elife. 2020.

• Hammer GD et al. Mouse models of adrenocortical tumors. Mol Cell Endocrinol. 2016.

• Hammer GD et al. 5th International ACC Symposium: Introduction. Horm Cancer. 2016.

• Hammer GD et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016.

• Hammer GD et al. Molecular Heterogeneity in Aldosterone-Producing Adenomas. J Clin Endocrinol Metab. 2016.

• Hammer GD et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016.

• Hammer GD et al. Stem cell function and plasticity in the normal physiology of the adrenal cortex. Mol Cell Endocrinol. 2021.

• Hammer GD et al. β-catenin in adrenal zonation and disease. Mol Cell Endocrinol. 2021.

• Hammoud et al. Regulation of meiotic progression by Sertoli-cell androgen signaling. Mol Biol Cell. 2020.

• Harder JL et al. High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Cell Stem Cell. 2018.

• Harder JL et al. Organoid single cell profiling identifies a transcriptional signature of glomerular disease. JCI Insight. 2020.

• Harder JL et al. Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker. JCI Insight. 2020.

• Harder JL et al. SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease. Kidney Int. 2020.

• Heemskerk et al. Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types. Development. 2022.

• Heemskerk I Full of potential: Pluripotent stem cells for the systems biology of embryonic patterning. Dev Biol. 2020.

• Heemskerk I et al. Tissue cartography: compressing bio-image data by dimensional reduction. Nat Methods. 2015.

• Heemskerk I et al. Differential growth triggers mechanical feedback that elevates Hippo signaling. Proc Natl Acad Sci U S A. 2016.

• Heemskerk I et al. Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells. Elife. 2019.

• Heemskerk I et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Phys Biol. 2021.

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• Zopf et al. Clinical Characteristics of Primary Snoring vs Mild Obstructive Sleep Apnea in Children Analysis of the Pediatric Adenotonsillectomy for Snoring (PATS) Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2024.

• Zopf et al. Webbed Neck Deformity Reconstruction in Patients with Turner Syndrome: Technical Considerations in Treating Congenital Pterygium Colli. Facial Plast Surg Aesthet Med. 2024.

• Zopf et al. Experience with trametinib in a pediatric patient with MAP2K1-related cervicofacial arteriovenous malformation. Pediatr Blood Cancer. 2024.

• Zopf et al. Incorporating a Three-Dimensional Printed Airway into a Pediatric Flexible Bronchoscopy Curriculum. AnnalsATS. 2024.

• Zopf et al. Current use of 3D printing in plastic surgery. Annals of 3D Printed Medicine. 2023.

• Zopf et al. Citric Acid Conditioning as an Alternative to EDTA for Growth Factors Release and Stem Cell Response in Regenerative Endodontics: A Systematic Review of In Vitro Studies. J Endod. 2024.