Nerve Repair/Neuroengineering
Michigan has been at the forefront of neurotechnology since the 1970s. Today a cluster of innovative, accomplished faculty is driving the field forward, working side-by-side with clinicians in the U-M Medical School to focus on translational applications to improve the lives of patients.
Researchers
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Carlos AguilarEngineering -
Mohammed AkaabouneLSA -
Steven BuchmanMedicine -
Paul CedernaMedicine -
Catherine CollinsLSA -
Keith DuncanMedicine -
Sean EdwardsDentistry
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Eva FeldmanMedicine -
Jianping FuEngineering -
Roman GigerMedicine -
Dan GoldmanMedicine -
Lori IsomMedicine -
Shigeki IwaseMedicine -
Stephen KempMedicine
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Jinsang KimEngineering
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Joerg LahannEngineering -
Lisa LarkinMedicine -
Paul LeeMedicine
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Jack ParentMedicine -
Rajesh RaoMedicine -
Lonnie SheaEngineering -
Gary D. SmithMedicine
Select Publications
Aguilar CA et al. Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma. Stem Cell Reports. 2016.
Aguilar CA et al. Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury. Cell Death Discov. 2018.
Aguilar CA et al. Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. J Immunology. 2020.
Aguilar CA et al. Dissecting murine muscle stem cell aging through integrative genomic analysis. Cell Rep. 2020.
Aguilar CA et al. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight. 2020.
Aguilar CA et al. Engineered Tools to Study Intercellular Communication. Adv Sci (Weinh). 2021.
Aguilar et al. Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Commun Biol. 2020.
Akaaboune M et al. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science. 1999.
Akaaboune M et al. Neurotransmitter Receptor Dynamics Studied in vivo by Reversible Photo-Unbinding of Fluorescent Ligands. Neuron. 2002.
Akaaboune M et al. Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin. J Cell Biol. 2011.
Akaaboune M et al. AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic Membrane of NMJs in Living Mice. J Neurosci. 2016.
Akaaboune M et al. The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice. Mol Metab. 2020.
Alford AI et al. Intersite reliability of vertebral bone marrow lipidomics-derived lipid composition among children with varying degrees of bone fragility undergoing routine orthopedic surgery. Bone. 2021.
Alford AI et al. Masquelet’s induced membrane technique: Review of current concepts and future directions. J Orthop Res. 2021.
Besirli et al. Surgical repair of primary non-complex rhegmatogenous retinal detachment in the modern era of small-gauge vitrectomy. BMJ Open Opthalmology 2021.
Besirli et al. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis. Sci Rep. 2020.
Besirli et al. Cryotherapy for the management of refractory hypotony secondary to post-goniotomy cyclodialysis cleft. Am J Ophthalmol Case Rep. 2020.
Besirli et al. Novel TMEM98, MFRP, PRSS56 variants in a large United States high hyperopia and nanophthalmos cohort. Sci Rep. 2020.
Besirli et al. Autophagy activation and photoreceptor survival in retinal detachment. Exp Eye Res. 2021.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. A Simplified Approach to Myelomeningocele Defect Repair. Ann Plast Surg. 2021.
Buchman SR et al. Achieving the Optimal Aesthetic Benefit While Correcting Midface Deficiency: Utilizing A High Winged Le Fort I in Cleft and Craniofacial Patients. J Craniofac Surg. 2021.
Cederna PS et al. Chronic Recording of Hand Prosthesis Control Signals Via a Regenerative Peripheral In a Rhesus Macaque. J Neural Eng. 2016.
Cederna PS et al. The Regenerative Peripheral Nerve Interface for Neuroma Management. JAMA Surg. 2018.
Cederna PS et al. Prosthetic Rehabilitation and Vascularized Composite Allotransplantation Following Upper Limb Loss. Plast Reconstr Surg. 2019.
Cederna PS et al. Prophylactic Regenerative Peripheral Nerve Interfaces (RPNIs) to Prevent Postamputation Pain. Plast Reconstr Surg. 2019.
Cederna PS et al. A Regenerative Peripheral Nerve Interface Allows Real-Time Control of an Artificial Hand In Upper Limb Amputees. Sci Transl Med. 2020.
Cederna PS et al. Reinventing Extremity Amputation in the Era of Functional Limb Restoration. Ann Surg. 2021.
Cederna PS et al. Developing Strategies for Targeted Improvement of Perioperative Education for Postbariatric Surgery Body-Contouring Patients. Ann Plast Surg. 2021.
Cederna PS et al. Commentary on: Trends and challenges of telehealth in an academic institution: The unforeseen benefits of the COVID-19 global pandemic. Aesthet Surg J. 2021.
Cederna PS et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Cederna PS et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Collins CA et al. Mitochondrial fission, integrity and clearance require separable functions of Vps13D in Drosophila neurons. bioRxiv. 2020.
Collins CA et al. Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J Cell Biol. 2010.
Collins CA et al. The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol. 2012.
Collins CA et al. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. eLife. 2016.
Collins CA et al. Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104. Elife. 2017.
Duncan RK et al. The intrinsic electrophysiological properties of neurons derived from mouse embryonic stem cells overexpressing neurogenin-1. Am J Physiol Cell Physiol. 2010.
Duncan RK et al. Combining topographical and genetic cues to promote neuronal fate specification in stem cells. Biomacromolecules. 2012.
Duncan RK et al. Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium. Sci Rep. 2017.
Duncan RK et al. Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration. PLoS One. 2017.
Duncan RK et al. From Otic Induction to Hair Cell Production: Pax2-EGFP Cell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model. Stem Cell Dev. 2018.
Feldman EL et al. Human neural stem cell transplantation into the corpus callosum of Alzheimer’s mice. Ann Clin Transl Neurol. 2017.
Feldman EL et al. Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS. Ann Clin Transl Neurol. 2018.
Feldman EL et al. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep. 2018.
Feldman EL et al. Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials. Expert Opin Investig Drugs. 2019.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2020.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2021.
Feldman EL et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Feldman EL et al. Inclusion body myositis: small steps towards future advances. Lanc Rheum. 2021.
Feldman et al. Untargeted metabolomics yields insight into ALS disease mechanisms. J Neurol Neurosurg Psychiatry. 2020.
Feldman et al. Covid-19 and diabetes: A collision and collusion of two diseases. Diabetes. 2020.
Feldman et al.Differential effects of empagliflozin on microvascular complications in murine models of type 1 and type 2 diabetes. Biology (Basel). 2020
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Giger RJ et al. Neuroinflammation triggered by ß-glucan/dectin-1 signaling enables CNS axon regeneration. Proc Natl Acad Sci U S A. 2015.
Giger RJ et al. A new neutrophil subset promotes CNS neuron survival and axon regeneration. Nat Immunol. 2020.
Giger RJ et al. Analysis of the immune response to sciatic nerve injury identified efferocytosis as a key mechanism of nerve debridement. bioRxiv. 2020.
Goldman D et al. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci. 2006.
Goldman D et al. Ascl1a regulates Müller glia dedifferentiation and retina regeneration via a Lin-28-dependent, let-7 miRNA signaling pathway. Nat Cell Biol. 2010.
Goldman D et al. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012.
Goldman D et al. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Proc Natl Acad Sci U S A. 2013.
Goldman D et al. Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. Elife. 2020.
Green GE et al. A 3D-printed Lateral Skull Base Implant for Repair of Tegmen Defects. Otol Neurotol. 2020.
Isom et al.Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry. 2020
Isom et al.Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Ann Clin Transl Neurol. 2020
Isom LL et al. SCN1B-linked early infantile developmental and epileptic encephalopathy. Ann Clin Transl Neurol. 2019.
Isom LL et al. Voltage-gated sodium channel ß1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. J Biol Chem. 2020.
Isom LL et al. Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Sci Transl Med. 2020.
Isom LL et al. Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons. Brain. 2020.
Isom LL et al. Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Ann Clin Transl Neurol. 2020.
Iwase et al. Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation. Commun Biol. 2020.
Iwase et al.X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. J Clin Inveset. 2020
Iwase S et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylase. Cell. 2007.
Iwase S et al. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol. 2011.
Iwase S et al. Sequencing of first-strand cDNA library reveals full-length transcriptomes. Nat Commun. 2015.
Iwase S et al. RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling. Cell Rep. 2020.
Kemp et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Kemp SWP et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Kim et al. Observation of magneto-electric rectification at non-relativistic intensities. Nat Commun. 2020.
Kozloff KM et al. In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging. Bone. 2021.
Kushner et al. Interactions between atmospheric pressure plasmas and metallic catalyst particles in packed bed reactors. J. Phys. D: Appl. Phys. 2021.
Kushner et al. Propagation of atmospheric pressure plasmas through interconnected pores in dielectric materials. J Appl Phys. 2021.
Lahann et al. Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy. Nat Commun. 2020.
Lahann J et al. Cooperative Switching in Large‐Area Assemblies of Magnetic Janus Particles. Adv Funct Mater. 2020.
Lahann J et al. 3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures. Adv Mater. 2018.
Lahann J et al. Templated nanofiber synthesis via chemical vapor polymerization into liquid crystalline films. Science. 2018.
Lahann J et al. Engineered Fibrillar Fibronectin Networks as Three Dimensional Tissue Scaffolds. Adv Mater. 2019.
Lahann J et al. Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting. Macromol Rapid Commun. 2020.
Lahann J et al. Stepwise cell seeding on tessellated scaffolds to study sprouting blood vessels. J Vis Exp. 2021.
Lahann J et al. Performance Fabrics Obtained by In Situ Growth of Metal-Organic Frameworks in Electrospun Fibers. ACS Appl Mater Interfaces. 2021.
Lahann J et al. Targeting gliomas with STAT3-silencing nanoparticles. Mol Cell Onc. 2021.
Lempka et al. Quantitative Sensory Testing of Spinal Cord and Dorsal Root Ganglion Stimulation in Chronic Pain Patients. Neuromodulation. 2021.
Mishina Y et al. Human–chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Nat Genet. 2021.
Nör JE et al. mTOR Inhibition Ablates Cisplatin-Resistant Salivary Gland Cancer Stem Cells. J Dent Res. 2021.
Nör JE et al. VEGFR1 primes a unique cohort of dental pulp stem cells for vasculogenic differentiation. Eur Cell Mater. 2021.
Parent et al.Seizure-Induced Neurogenesis: 1 Out of 3 Ain’t Bad. Epilepsy Curr. 2020
Parent JM et al. Critical roles of ɑII spectrin in brain development and epileptic encephalopathy. J Clin Invest. 2018.
Parent JM et al. Modeling genetic epilepsies in a dish. Dev Dyn. 2020.
Parent JM et al. Altered synaptic drive onto birthdated dentate granule cells in experimental temporal lobe epilepsy. J Neurosci. 2019.
Parent JM et al. Multimodal analysis of STRADA function in brain Development. Front Cell Neurosci. 2020.
Parent JM et al. Variant-Specific Changes in Persistent or Resurgent Sodium Current in SCN8A-Related Epilepsy Patient-Derived Neurons. Brain. 2020.
Parkos CA et al. Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal Immunol. 2021.
Parkos CA et al. Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2. Mol Biol Cell. 2021.
Rao RC et al. Efficient serum-free derivation of oligodendrocyte precursors from neural stem cell-enriched cultures. Stem Cells. 2009.
Rao RC et al. Dynamic patterns of histone lysine methylation in the developing retina. Invest Ophthalmol Vis Sci. 2010.
Rao RC et al. Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1. Sci Rep. 2016.
Rao RC et al. Stem Cells for Retinal Disease: A Perspective on the Promise and Perils. Am J Ophthalmol. 2017.
Rao RC et al. p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Cell Rep. 2020.
Rao RC et al. The endangered physician-scientist and COVID-19. Cell Rep Med. 2021.
Scott et al. Iridium-Catalysed C−H Borylation of Heteroarenes: Balancing Steric and Electronic Regiocontrol. Angew Chem Int Ed Engl. 2021.
Scott et al. On the consensus nomenclature rules for radiopharmaceutical chemistry – Reconsideration of radiochemical conversion. Nucl Med Biol. 2021.
Scott et al. An updated synthesis of N1′-([11C]methyl)naltrindole for positron emission tomography imaging of the delta opioid receptor. J Labelled Comp Radiopharm. 2021.
Shea et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea LD et al. Microporous scaffolds support assembly and differentiation of pancreatic progenitors into ß-cell clusters. Acta Biomater. 2019.
Shea LD et al. Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2019.
Shea LD et al. Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes. Cancer Res. 2020.
Shea LD et al. Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. Tissue Eng Part A. 2020.
Shea LD et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea LD et al. An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides. J Control Release. 2021.
Shea LD et al. Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials. 2021.
Shea LD et al. Cargo-free immunomodulatory nanoparticles combined with anti-PD-1 antibody for treating metastatic breast cancer. Biomaterials. 2021.
Shtein et al. Kirigami-Based Compliant Mechanism for Multiaxis Optical Tracking and Energy-Harvesting Applications. Adv Eng Mat. 2021.
Si et al. Unicuspid Aortic Valve Repair Using Geometric Ring Annuloplasty. Ann Thorac Surg. 2021.
Si et al. Berlin Heart EXCOR and ACTION post-approval surveillance study report. J Heart Lung Transplant 2021.
Smith et al. Lipidomic markers of sperm cryotolerance in cattle. Sci Rep. 2020.
Smith GD et al. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes. J Mol Cell Cardiol. 2016.
Smith GD et al. Targeted reactivation of FMR1 transcription in fragile X syndrome embryonic stem cells. Front Mol Neurosci. 2018.
Smith GD et al. Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line. Stem Cell Res. 2019.
Smith GD et al. Histone acetyltransferase MOF regulates fatty acid oxidation and cellular metabolism in cell fate determination. Cell Stem Cell. 2020.
Smith GD et al. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020.
Weivoda MM et al. miRNAs in osteoclast biology. Bone. 2021.