Nerve Repair/Neuroengineering

Michigan has been at the forefront of neurotechnology since the 1970s. Today a cluster of innovative, accomplished faculty is driving the field forward, working side-by-side with clinicians in the U-M Medical School to focus on translational applications to improve the lives of patients.

Join Our Research

Researchers

Carlos Aguilar

Engineering
Mohammed Akaaboune

LSA
Steven Buchman

Medicine
Paul Cederna

Medicine
Catherine Collins

LSA
Keith Duncan

Medicine
Sean Edwards

Dentistry
Joshua Emrick

Dentistry
Eva Feldman

Medicine
Jianping Fu

Engineering
Deanna Gates

LSA
Roman Giger

Medicine
Dan Goldman

Medicine
Lori Isom

Medicine
Shigeki Iwase

Medicine
Stephen Kemp

Medicine
Jinsang Kim

Engineering
Joerg Lahann

Engineering
Lisa Larkin

Medicine
Paul Lee

Medicine
Aaron Morris

Engineering
Jack Parent

Medicine
Rajesh Rao

Medicine
Lonnie Shea

Engineering
Gary D. Smith

Medicine

View our research

Select Publications

Aguilar CA et al. Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma. Stem Cell Reports. 2016.
Aguilar CA et al. Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury. Cell Death Discov. 2018.
Aguilar CA et al. Tuning Macrophage Phenotype to Mitigate Skeletal Muscle Fibrosis. J Immunology. 2020.
Aguilar CA et al. Dissecting murine muscle stem cell aging through integrative genomic analysis. Cell Rep. 2020.
Aguilar CA et al. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight. 2020.
Aguilar CA et al. Engineered Tools to Study Intercellular Communication. Adv Sci (Weinh). 2021.
Aguilar CA et al. Metabolipidomic profiling reveals an age-related deficiency of skeletal muscle pro-resolving mediators that contributes to maladaptive tissue remodeling. Aging Cell. 2021.
Aguilar CA et al. Sestrins regulate muscle stem cell metabolic homeostasis. Stem Cell Reports. 2021.
Aguilar et al. Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss. Commun Biol. 2020.
Aguilar et al. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci U S A. 2022.
Aguilar et al. Three-dimensional chromatin re-organization during muscle stem cell aging. Aging Cell. 2023.
Aguilar et al. Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss. JCI Insight. 2023.
Akaaboune et al. Distinct roles of the dystrophin-glycoprotein complex: α-dystrobrevin and α-syntrophin in the maintenance of the postsynaptic apparatus of the neuromuscular synapse. Hum Mol Genet. 2022.
Akaaboune M et al. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science. 1999.
Akaaboune M et al. Neurotransmitter Receptor Dynamics Studied in vivo by Reversible Photo-Unbinding of Fluorescent Ligands. Neuron. 2002.
Akaaboune M et al. Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin. J Cell Biol. 2011.
Akaaboune M et al. AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic Membrane of NMJs in Living Mice. J Neurosci. 2016.
Akaaboune M et al. The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice. Mol Metab. 2020.
Alford AI et al. Intersite reliability of vertebral bone marrow lipidomics-derived lipid composition among children with varying degrees of bone fragility undergoing routine orthopedic surgery. Bone. 2021.
Alford AI et al. Masquelet’s induced membrane technique: Review of current concepts and future directions. J Orthop Res. 2021.
Alford et al. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts. Bone. 2021.
Arruda et al. Investigation of Fiber-Driven Mechanical Behavior of Human and Porcine Bladder Tissue Tested Under Identical Conditions. J Biomech Eng. 2021.
Arruda et al. The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review. J Biomech Eng. 2022.
Arruda et al. Ogden material calibration via magnetic resonance cartography, parameter sensitivity and variational system identification. Philos Trans A Math Phys Eng Sci. 2022.
Arruda et al. Topological transformability and reprogrammability of multistable mechanical metamaterials. Proc Natl Acad Sci U S A. 2022.
Arruda et al. Constitutive modeling of the anterior cruciate ligament bundles and patellar tendon with full-field methods. J Mech Phys Solids. 2021.
Arruda et al. Inference of deformation mechanisms and constitutive response of soft material surrogates of biological tissue by full-field characterization and data-driven variational system identification. J Mech A Solid 2021.
Arruda et al. Fractional topological solitons in nonlinear viscoelastic ribbons with tunable speed. Extreme Mech Lett. 2023.
Besirli et al. Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database. Eur J Ophthalmol. 2022.
Besirli et al. Perifoveal Chorioretinal Atrophy after Subretinal Voretigene Neparvovec-rzyl for RPE65-Mediated Leber Congenital Amaurosis. Ophthalmol Retina. 2022.
Besirli et al. Referable Macular Hemorrhage-A Clinically Meaningful Screening Target in Newborn Infants. Position Statement of the Association of Pediatric Retina Surgeons. Ophthalmic Surg Lasers Imaging Retina. 2022.
Besirli et al. Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration. Nanomedicine. 2022.
Besirli et al. Surgical repair of primary non-complex rhegmatogenous retinal detachment in the modern era of small-gauge vitrectomy. BMJ Open Opthalmology 2021.
Besirli et al. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis. Sci Rep. 2020.
Besirli et al. Coats-like Exudative Vitreoretinopathy in Retinitis Pigmentosa: Ocular Manifestations and Treatment Outcomes. Opthalmol Retina. 2021.
Besirli et al. Cryotherapy for the management of refractory hypotony secondary to post-goniotomy cyclodialysis cleft. Am J Ophthalmol Case Rep. 2020.
Besirli et al. Novel TMEM98, MFRP, PRSS56 variants in a large United States high hyperopia and nanophthalmos cohort. Sci Rep. 2020.
Besirli et al. A novel OCT signature in leukemic papillopathy masquerading as autoimmune or infectious uveitis. Graefes Arch Clin Exp Opthalmol. 2021.
Besirli et al. Autophagy activation and photoreceptor survival in retinal detachment. Exp Eye Res. 2021.
Besirli et al. Outcomes of Baerveldt Glaucoma Drainage Devices in Pediatric Eyes. J Glaucoma. 2022.
Besirli et al. Real-world outcomes of voretigene neparvovec treatment in pediatric patients with RPE65-associated Leber congenital amaurosis. Graefes Arch Clin Exp Ophthalmol. 2022.
Besirli et al. Scleral Histopathologic Findings of Hurler-Scheie Syndrome with Refractory Glaucoma. JAMA Ophthalmol. 2022.
Besirli et al. Late Vitreoretinal Complications of Regressed Retinopathy of Prematurity: Retinal Break, Vitreous Hemorrhage, and Retinal Detachment. Ophthalmol Retina. 2023.
Besirli et al. Practice Patterns and Outcomes of Intravitreal Anti-VEGF Injection for Retinopathy of Prematurity: An International Multicenter Study. Ophthalmology. 2022.
Besirli et al. A Caveat About Financial Incentives for Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Retinopathy. Am J Ophthalmol. 2022.
Besirli et al. COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM AT PEDIATRIC AGE: Surgical Versus Conservative Approach. Retina. 2023.
Besirli et al. Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity: A Multicenter Study. Ophthalmology. 2023.
Besirli et al. Retinal Neovascularization in Posterior Polar Annular Choroidal Dystrophy. JAMA Ophthalmol. 2023.
Besirli et al. Scleral Windows in the Treatment of Uveal Effusion Syndrome. Ophthalmic Surg Lasers Imaging Retina. 2022.
Besirli et al. Quantitative analysis of tear angiogenic factors in retinopathy of prematurity: a pilot biomarker study. J AAPOS. 2023.
Besirli et al. The impact of the COVID-19 lockdown on retinopathy of prematurity screening and management in the United States: a multicenter study. J AAPOS. 2023.
Besirli et al. Flow cytometric method for the detection and quantification of retinal cell death and oxidative stress. Exp Eye Res. 2023.
Besirli et al. Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration. Cells. 2023.
Besirli, et al. Characteristics of Retinal Detachment after Pediatric Open-Globe Injuries. Ophthalmol Retina. 2021.
Buchman et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Buchman et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Buchman et al. Institutional trends in opioid prescribing and utilization after primary cleft lip and palate repair. Plast Reconstr Surg. 2022.
Buchman et al. Reply: Management of Calcified Cephalohematoma of Infancy: The University of Michigan 25-Year Experience. Plast Reconstr Surg. 2022.
Buchman et al. Surgical Timing and Neurocognitive Development among Patients with Craniosynostosis: Analysis of Confounders. Plast Reconstr Surg. 2023.
Buchman et al. Managing the Soft-Tissue Envelope in Facial Feminization Surgery: Filling and Tightening Surgical Approaches. Plast Reconstr Surg. 2023.
Buchman et al. Longitudinal Assessment of Neurodevelopment in Patients With Nonsyndromic Single-Suture Craniosynostosis: A Retrospective Review of 66 Patients. J Craniofac Surg. 2023.
Buchman et al. Adipose-Derived Stem Cells Enhance Graft Incorporation and Mineralization in a Murine Model of Irradiated Mandibular Nonvascularized Bone Grafting. Ann Plast Surg. 2023.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. A Simplified Approach to Myelomeningocele Defect Repair. Ann Plast Surg. 2021.
Buchman SR et al. Achieving the Optimal Aesthetic Benefit While Correcting Midface Deficiency: Utilizing A High Winged Le Fort I in Cleft and Craniofacial Patients. J Craniofac Surg. 2021.
Buchman SR et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Cederna et al. Commentary on: Resident Exposure to Aesthetic Surgical and Nonsurgical Procedures during Canadian Residency Program Training. Aesthet Surg J. 2021.
Cederna et al. Comparison of Outcomes of Spinal Accessory to Suprascapular Nerve Transfer Versus Nerve Grafting for Neonatal Brachial Plexus Injury. Orthopedics. 2022.
Cederna et al. The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals. J Vis Exp. 2022.
Cederna et al. Meshach Haskell (Hack) Newman, M.S., M.D., 1937 to 2021. Plast Reconstr Surg. 2022.
Cederna et al. Aesthetic Surgery in Plastic Surgery Academia. Aesthet Surg J. 2021.
Cederna et al. Regenerative Peripheral Nerve Interfaces for Advanced Control of Upper Extremity Prosthetic Devices. Hand Clin. 2021.
Cederna et al. Neuroma, Neural Interface, and Prosthetics. Hand Clin. 2021.
Cederna et al. Gender Affirming Mastectomy Improves Quality of Life in Transmasculine Patients: A Single-center Prospective Study. Ann Surg. 2023.
Cederna et al. Impact of Cell Seeding Density and Cell Confluence on Human Tissue Engineered Skeletal Muscle. Tissue Eng Part A. 2022.
Cederna et al. “Decreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)”. Ann Vasc Surg. 2022.
Cederna et al. The Current State of Fat Grafting in the Hand: A Systematic Review for Hand Diseases. Hand (N Y). 2023.
Cederna et al. Reply: Facial Transplantation: A Dilemma of the Four Basic Medical Ethics Principles. Plast Reconstr Surg. 2022.
Cederna et al. Sensory nerve regeneration and reinnervation in muscle following peripheral nerve injury. Musle Nerve. 2022.
Cederna et al. Pathophysiological and Neuroplastic Changes in Postamputation and Neuropathic Pain: Review of the Literature. Plast Reconstr Surg Glob Open. 2022.
Cederna et al. From Here to There: A Celebration of the Life and Contributions of Reed O. Dingman. J Craniofac Surg. 2023.
Cederna et al. Ultrasound appearance of regenerative peripheral nerve interface with clinical correlation. Skeletal Radiol. 2023.
Cederna et al. Upper limb prostheses: bridging the sensory gap. J Hand Surg Eur Vol. 2023.
Cederna et al. Dermal Sensory Regenerative Peripheral Nerve Interface for Reestablishing Sensory Nerve Feedback in Peripheral Afferents in the Rat. Plast Reconstr Surg. 2023.
Cederna et al. Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes. J Neural Eng. 2023.
Cederna et al. Regenerative Peripheral Nerve Interface Surgery: Anatomic and Technical Guide. Plast Reconstr Surg Glob Open. 2023.
Cederna PS et al. Chronic Recording of Hand Prosthesis Control Signals Via a Regenerative Peripheral In a Rhesus Macaque. J Neural Eng. 2016.
Cederna PS et al. The Regenerative Peripheral Nerve Interface for Neuroma Management. JAMA Surg. 2018.
Cederna PS et al. Prosthetic Rehabilitation and Vascularized Composite Allotransplantation Following Upper Limb Loss. Plast Reconstr Surg. 2019.
Cederna PS et al. Prophylactic Regenerative Peripheral Nerve Interfaces (RPNIs) to Prevent Postamputation Pain. Plast Reconstr Surg. 2019.
Cederna PS et al. A Regenerative Peripheral Nerve Interface Allows Real-Time Control of an Artificial Hand In Upper Limb Amputees. Sci Transl Med. 2020.
Cederna PS et al. Reinventing Extremity Amputation in the Era of Functional Limb Restoration. Ann Surg. 2021.
Cederna PS et al. Developing Strategies for Targeted Improvement of Perioperative Education for Postbariatric Surgery Body-Contouring Patients. Ann Plast Surg. 2021.
Cederna PS et al. Commentary on: Trends and challenges of telehealth in an academic institution: The unforeseen benefits of the COVID-19 global pandemic. Aesthet Surg J. 2021.
Cederna PS et al. Impact of Human Epidermal Growth Factor on Tissue-Engineered Skeletal Muscle Structure and Function. Tissue Eng Part A. 2021.
Cederna PS et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Cederna PS et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Chen et al. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovasc Drugs Ther. 2021.
Chen et al. Impact of donor blood type on outcomes after prolonged allograft ischemic times. J Thorac Cardiovasc Surg. 2022.
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen et al. Risk factors for heart transplant survival with greater than 5 h of donor heart ischemic time. J Card Surg. 2021.
Chen et al. Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31/FIH1/HIF-1α pathway. J Mol Cell Cardiol. 2022.
Chen et al. RNA sequencing reveals perivascular adipose tissue plasticity in response to angiotensin II. Pharmacol Res. 2022.
Chen et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. Redox Biol. 2022.
Chen et al. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. J Clin Invest. 2022.
Chen et al. Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis. Cells. 2022.
Chen et al. Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Adv Sci (Weinh). 2023.
Chen et al. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates. Cell Metab. 2023.
Chen et al. PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm. JCI Insight. 2023.
Chen et al. Circular RNA as Therapeutic Targets in Atherosclerosis: Are We Running in Circles?. J Clin Med. 2023.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Chen YE et al. Translating Cardiovascular Genomics to Clinical Practice. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Improving the genome assembly of rabbits with long-read sequencing. Genomics. 2021.
Chen YE et al. Biomimetic tubular scaffold with heparin conjugation for rapid degradation in in situ regeneration of a small diameter neoartery. Biomaterials. 2021.
Chen YE et al. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm. Am J Hum Genet. 2021.
Coleman et al. Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies. Curr Rheumatol Rep. 2022.
Collins CA et al. Mitochondrial fission, integrity and clearance require separable functions of Vps13D in Drosophila neurons. bioRxiv. 2020.
Collins CA et al. Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J Cell Biol. 2010.
Collins CA et al. The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol. 2012.
Collins CA et al. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. eLife. 2016.
Collins CA et al. Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104. Elife. 2017.
Duncan RK et al. The intrinsic electrophysiological properties of neurons derived from mouse embryonic stem cells overexpressing neurogenin-1. Am J Physiol Cell Physiol. 2010.
Duncan RK et al. Combining topographical and genetic cues to promote neuronal fate specification in stem cells. Biomacromolecules. 2012.
Duncan RK et al. Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium. Sci Rep. 2017.
Duncan RK et al. Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration. PLoS One. 2017.
Duncan RK et al. From Otic Induction to Hair Cell Production: Pax2-EGFP Cell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model. Stem Cell Dev. 2018.
Feldman EL et al. Human neural stem cell transplantation into the corpus callosum of Alzheimer’s mice. Ann Clin Transl Neurol. 2017.
Feldman EL et al. Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS. Ann Clin Transl Neurol. 2018.
Feldman EL et al. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep. 2018.
Feldman EL et al. Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials. Expert Opin Investig Drugs. 2019.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2020.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2021.
Feldman EL et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Feldman EL et al. Inclusion body myositis: small steps towards future advances. Lanc Rheum. 2021.
Feldman et al. Untargeted metabolomics yields insight into ALS disease mechanisms. J Neurol Neurosurg Psychiatry. 2020.
Feldman et al. Covid-19 and diabetes: A collision and collusion of two diseases. Diabetes. 2020.
Feldman et al.Differential effects of empagliflozin on microvascular complications in murine models of type 1 and type 2 diabetes. Biology (Basel). 2020
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Giger RJ et al. Neuroinflammation triggered by ß-glucan/dectin-1 signaling enables CNS axon regeneration. Proc Natl Acad Sci U S A. 2015.
Giger RJ et al. A new neutrophil subset promotes CNS neuron survival and axon regeneration. Nat Immunol. 2020.
Giger RJ et al. Analysis of the immune response to sciatic nerve injury identified efferocytosis as a key mechanism of nerve debridement. bioRxiv. 2020.
Goldman D et al. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci. 2006.
Goldman D et al. Ascl1a regulates Müller glia dedifferentiation and retina regeneration via a Lin-28-dependent, let-7 miRNA signaling pathway. Nat Cell Biol. 2010.
Goldman D et al. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012.
Goldman D et al. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Proc Natl Acad Sci U S A. 2013.
Goldman D et al. Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. Elife. 2020.
Green GE et al. A 3D-printed Lateral Skull Base Implant for Repair of Tegmen Defects. Otol Neurotol. 2020.
Isom et al. Gastrointestinal Symptoms and Channelopathy-Associated Epilepsy. J Pediatr. 2021.
Isom et al. Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress. Epilepsia. 2022.
Isom et al. Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit. J Biol Chem. 2022.
Isom et al. Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules. Pharmacol Rev. 2022.
Isom et al. DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models. PLoS Biol. 2023.
Isom et al.Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry. 2020
Isom et al.Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Ann Clin Transl Neurol. 2020
Isom LL et al. SCN1B-linked early infantile developmental and epileptic encephalopathy. Ann Clin Transl Neurol. 2019.
Isom LL et al. Voltage-gated sodium channel ß1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. J Biol Chem. 2020.
Isom LL et al. Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Sci Transl Med. 2020.
Isom LL et al. Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons. Brain. 2020.
Isom LL et al. Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Ann Clin Transl Neurol. 2020.
Iwase et al. Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nat Commun. 2022.
Iwase et al. Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation. Commun Biol. 2020.
Iwase et al. Soma-to-germline transformation in chromatin-linked neurodevelopmental disorders?. FEBS J. 2022.
Iwase et al. Sexually Dimorphic Alterations in the Transcriptome and Behavior with Loss of Histone Demethylase KDM5C. Cells. 2023.
Iwase et al. Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression. Biochem Soc Trans. 2023.
Iwase et al. Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity. J Cell Biol. 2023.
Iwase et al.X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. J Clin Inveset. 2020
Iwase S et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylase. Cell. 2007.
Iwase S et al. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol. 2011.
Iwase S et al. Sequencing of first-strand cDNA library reveals full-length transcriptomes. Nat Commun. 2015.
Iwase S et al. RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling. Cell Rep. 2020.
Kemp et al. Comparison of Outcomes of Spinal Accessory to Suprascapular Nerve Transfer Versus Nerve Grafting for Neonatal Brachial Plexus Injury. Orthopedics. 2022.
Kemp et al. The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals. J Vis Exp. 2022.
Kemp et al. Regenerative peripheral nerve interface free muscle graft mass and function. Muscle Nerve. 2021.
Kemp et al. “Decreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)”. Ann Vasc Surg. 2022.
Kemp et al. Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-Dimension, Cuff-Less Microneedle Electrode Array. Small. 2022.
Kemp et al. Pathophysiological and Neuroplastic Changes in Postamputation and Neuropathic Pain: Review of the Literature. Plast Reconstr Surg Glob Open. 2022.
Kemp et al. Ultrasound appearance of regenerative peripheral nerve interface with clinical correlation. Skeletal Radiol. 2023.
Kemp et al. Dermal Sensory Regenerative Peripheral Nerve Interface for Reestablishing Sensory Nerve Feedback in Peripheral Afferents in the Rat. Plast Reconstr Surg. 2023.
Kemp et al. Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes. J Neural Eng. 2023.
Kemp SWP et al.The clinical significance of a swollen neuroma: A meaningful distinction or an incidental finding? Ann Palliat Med. 2020
Kim et al. Observation of magneto-electric rectification at non-relativistic intensities. Nat Commun. 2020.
Kozloff et al. Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts. Bone. 2021.
Kozloff et al. Systemic administration of recombinant irisin accelerates fracture healing in mice. Int J Mol Sci. 2021.
Kozloff et al. Position-Specific Physical Workload Intensities in American Collegiate Football Training. J Strength Cond Res. 2022.
Kozloff et al. Tibial nerve stimulation increases vaginal blood perfusion and bone mineral density and yield load in ovariectomized rat menopause model. Int Urogynecol J. 2022.
Kozloff et al. Matrix/mineral ratio and domain size variation with bone tissue age: A photothermal infrared study. J Struct Biol. 2022.
Kozloff KM et al. In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging. Bone. 2021.
Kozloff KM et al. Altered collagen chemical compositional structure in osteopenic women with past fractures: A case-control Raman spectroscopic study. Bone. 2021.
Kozloff KM et al. The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo. Photoacoustics. 2021.
Kushner et al. Pulsed power to control growth of silicon nanoparticles in low temperature flowing plasmas. J Appl Phys. 2022.
Kushner et al. Positive charging of grains in an afterglow plasma is enhanced by ions drifting in an electric field. Phys Plasmas. 2021.
Kushner et al. Comparison of glancing-angle scatterings on different materials in a high aspect ratio plasma etching process using molecular dynamics simulation. J Vac Sci Technol. 2022.
Kushner et al. Scaling of atomic layer etching of SiO2in fluorocarbon plasmas: Transient etching and surface roughness. J. Vac. Sci. Technol. 2021.
Kushner et al. Interactions between atmospheric pressure plasmas and metallic catalyst particles in packed bed reactors. J. Phys. D: Appl. Phys. 2021.
Kushner et al. Plasma breakdown in bubbles passing between two pin electrodes. J Phys D. 2022.
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