Diabetes
Diabetes is a very active area of research at Michigan, ranging from basic science investigations to clinical and translational research.
Researchers
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Mohammed AkaabouneLSA -
Brendon BakerMedicine -
Steven BuchmanMedicine -
Eugene ChenMedicine -
Cunming DuanLSA -
Eva FeldmanMedicine -
Katherine GallagherMedicine -
Dan GoldmanMedicine -
Jennifer HarderMedicine -
Jinsang KimEngineering -
David KohnDentistry -
James MoonPharmacy -
Andy PutnamEngineering -
Rajesh RaoMedicine -
Liangyou RuiMedicine -
Lonnie SheaEngineering -
Scott SoleimanpourMedicine
Select Publications
Akaaboune M et al. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science. 1999.
Akaaboune M et al. Neurotransmitter Receptor Dynamics Studied in vivo by Reversible Photo-Unbinding of Fluorescent Ligands. Neuron. 2002.
Akaaboune M et al. Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin. J Cell Biol. 2011.
Akaaboune M et al. AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic Membrane of NMJs in Living Mice. J Neurosci. 2016.
Akaaboune M et al. The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice. Mol Metab. 2020.
Baker BM et al. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017.
Baker BM et al. Cell force-mediated matrix reorganization underlies multicellular network assembly. Sci Rep. 2019.
Baker BM et al. Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration. Nat Commun. 2019.
Baker BM et al. Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Lab Chip. 2020.
Baker BM et al. Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis. Sci Adv. 2020.
Baker BM et al. Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices. Biomater Sci. 2021.
Baker BM et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.
Baker BM et al. Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform. Lab Chip. 2021.
Baker BM et al. New directions and dimensions for bioengineered models of fibrosis. Nat Review Mater. 2021.
Baker BM et al. Quantification and immunoprofiling of bladder cancer cell-derived extracellular vesicles with microfluidic chemiluminescent ELISA. Biosens Bioelectron: X. 2021.
Baker et al. Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation. Acta Biomater. 2021.
Baker et al. Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology. Adv Mater. 2021.
Baker et al. Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening. Acta Biomater. 2022.
Baker et al. Micropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting. Bioprinting. 2022.
Baker et al. Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D. Adv Sci (weinh). 2022.
Baker et al. The living interface between synthetic biology and biomaterial design. Nat Mater. 2022.
Buchman et al. Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. Int J Oral Maxillofac Surg. 2022.
Buchman et al. Impact of sleep-disordered breathing on behavior and quality of life in children aged 2 to 7 years with non-syndromic cleft lip and/or palate. Pediatr Pulmonol. 2021.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Buchman SR et al. A Simplified Approach to Myelomeningocele Defect Repair. Ann Plast Surg. 2021.
Buchman SR et al. Achieving the Optimal Aesthetic Benefit While Correcting Midface Deficiency: Utilizing A High Winged Le Fort I in Cleft and Craniofacial Patients. J Craniofac Surg. 2021.
Buchman SR et al. Sleep-related movement disorders and growing pains: differences in daytime and bedtime behavior in 2–6 year old children with cleft palate. Sleep Med. 2021.
Cederna PS et al. Impact of Human Epidermal Growth Factor on Tissue-Engineered Skeletal Muscle Structure and Function. Tissue Eng Part A. 2021.
Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.
Chen YE et al. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration. Biomaterials. 2015.
Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.
Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.
Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.
Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.
Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.
Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.
Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Coleman et al. Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies. Curr Rheumatol Rep. 2022.
Dressler et al. Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021.
Dressler et al. Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation. Cell Chem Biol. 2022.
Duan C et al. Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc Natl Acad Sci U S A. 2010.
Duan C et al. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 2014.
Duan C et al. Ca2+ concentration-dependent premature death of igfbp5a mutant zebrafish reveals a critical role of IGF signaling in adaptive epithelial growth. Sci Signal. 2018.
Duan C et al. Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. Elife. 2019.
Duan C et al. The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. Elife. 2020.
Duan et al. Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Front Cell Dev Biol. 2021.
Duan et al. IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. Gen Comp Endocrinol. 2021.
Duncan et al. The nematode C. elegans senses airborne sound. Neuron. 2021.
Duncan et al. Measurements From Ears With Endolymphatic Hydrops and 2-Hydroxypropyl-Beta-Cyclodextrin Provide Evidence That Loudness Recruitment Can Have a Cochlear Origin. Front Surg. 2021.
Duncan RK et al. Matrigel is required for efficient differentiation of isolated, stem cell-derived otic vesicles into inner ear organoids. Stem Cell Res. 2021.
Feldman EL et al. Human neural stem cell transplantation into the corpus callosum of Alzheimer’s mice. Ann Clin Transl Neurol. 2017.
Feldman EL et al. Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS. Ann Clin Transl Neurol. 2018.
Feldman EL et al. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease. Sci Rep. 2018.
Feldman EL et al. Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials. Expert Opin Investig Drugs. 2019.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2020.
Feldman EL et al. Magnetic resonance imaging of human neural stem cells in rodent and primate brain. Stem Cells Transl Med. 2021.
Feldman EL et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Feldman EL et al. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight 2021.
Feldman EL et al. Inclusion body myositis: small steps towards future advances. Lanc Rheum. 2021.
Feldman et al. Untargeted metabolomics yields insight into ALS disease mechanisms. J Neurol Neurosurg Psychiatry. 2020.
Feldman et al. Covid-19 and diabetes: A collision and collusion of two diseases. Diabetes. 2020.
Feldman et al.Differential effects of empagliflozin on microvascular complications in murine models of type 1 and type 2 diabetes. Biology (Basel). 2020
Giger RJ et al. THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes. Proc Natl Acad Sci USA. 2021.
Goldman D et al. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci. 2006.
Goldman D et al. Ascl1a regulates Müller glia dedifferentiation and retina regeneration via a Lin-28-dependent, let-7 miRNA signaling pathway. Nat Cell Biol. 2010.
Goldman D et al. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration. Dev Cell. 2012.
Goldman D et al. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Proc Natl Acad Sci U S A. 2013.
Goldman D et al. Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. Elife. 2020.
Harder JL et al. High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Cell Stem Cell. 2018.
Harder JL et al. Organoid single cell profiling identifies a transcriptional signature of glomerular disease. JCI Insight. 2020.
Harder JL et al. Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker. JCI Insight. 2020.
Harder JL et al. SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease. Kidney Int. 2020.
Heemskerk I et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Phys Biol. 2021.
Isom et al. Gastrointestinal Symptoms and Channelopathy-Associated Epilepsy. J Pediatr. 2021.
Isom et al. Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits. JCI Insight 2021.
Iwase et al. Soma-to-germline transformation in chromatin-linked neurodevelopmental disorders?. FEBS J. 2022.
Kim et al. Observation of magneto-electric rectification at non-relativistic intensities. Nat Commun. 2020.
Kohn DH et al. Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A. 2009.
Kohn DH et al. Gene delivery via DNA incorporation within a biomimetic apatite coating. Biomaterials. 2009.
Kohn DH et al. PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol. 2016.
Kohn DH et al. Dual-functioning peptides discovered by phage display increase the magnitude and specificity of BMSC attachment to mineralized biomaterials. Biomaterials. 2017.
Kohn DH et al. Cell and material-specific phage display peptides increase iPS-MSC mediated bone and vasculature formation in vivo. Adv Healthc Mater. 2019.
Kretzler et al. The clinical application of urine soluble CD163 in ANCA-associated vasculitis. J Am Soc Nephrol. 2021.
Kretzler et al. Nephrotic syndrome disease activity is proportional to its associated hypercoagulopathy. Thromb Res. 2021.
Kretzler et al. Rationale and design of the Kidney Precision Medicine Project. Kidney Int. 2021.
Kretzler et al. Patient perspectives and involvement in precision medicine research. Kidney Int. 2021.
Kretzler et al. Innovating and invigorating the clinical trial infrastructure for glomerular diseases. Kidney Int. 2021.
Kretzler et al. APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis. Pediatr Nephrol. 2021.
Kretzler et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 2021.
Kretzler et al. IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes. Diabetologia. 2021.
Kretzler et al. Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice. Clin Sci (Lond). 2021.
Kretzler et al. Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021.
Kretzler et al. Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building Meeting. Front Pharmacol. 2021.
Kretzler et al. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis. Kidney Int. 2021.
Kretzler et al. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. J Clin Invest. 2021.
Kretzler et al. Comprehensive search for novel circulating mirnas and axon guidance pathway proteins associated with risk of eskd in diabetes. J Am Soc Nephrol. 2021.
Kretzler et al. Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy. JCI Insight. 2021.
Kretzler et al. Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes. Am J Kidney Dis. 2022.
Kretzler et al. Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney. Am J Transplant. 2022.
Kretzler et al. Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants. Kidney Int. 2022.
Kretzler et al. Unsupervised machine learning for identifying important visual features through bag-of-words using histopathology data from chronic kidney disease. Sci Rep. 2022.
Kretzler et al. Micro-dissection and integration of long and short reads to create a robust catalog of kidney compartment-specific isoforms. PLoS Comput Biol. 2022.
Kretzler et al. Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. Nat Genet. 2021.
Larkin et al. Impact of Human Epidermal Growth Factor on Tissue-Engineered Skeletal Muscle Structure and Function. Tissue Eng Part A. 2021.
Mistretta et al. The fungiform papilla is a complex, multimodal, oral sensory organ. Curr Opin Physiol. 2021.
Mistretta et al. Probing the multimodal fungiform papilla: complex peripheral nerve endings of chorda tympani taste and mechanosensitive fibers before and after Hedgehog pathway inhibition. Cell Tissue Res. 2022.
Moon et al. Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome. Adv Drug Deliv Rev. 2021.
Moon et al. Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel. Nat Biomed Eng. 2021.
Moon JJ et al. Modularly Programmable Nanoparticle Vaccine Based on Polyethyleneimine for Personalized Cancer Immunotherapy. Adv Sci. 2021.
Moon JJ et al. Designer vaccine nanodiscs for personalized cancer immunotherapy. Nat Mater. 2017.
Moon JJ et al. Engineering strategies for personalized cancer immunotherapy: a paradigm shift. Nat Biomed Eng. 2019.
Moon JJ et al. Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome, and immune responses in colitis. Nat Mater. 2020.
Moon JJ et al. Multilamellar Vaccine Particle Elicits Potent Immune Activation with Protein Antigens and Protects Mice against Ebola Virus Infection. ACS Nano. 2019.
Moon JJ et al. Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice. J Clin Invest. 2021.
Moon JJ et al. Non-viral COVID-19 vaccine delivery systems. Adv Drug Deliv Rev. 2021.
Moon JJ et al. Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2. J Control Release. 2021.
Moon JJ et al. Modularly Programmable Nanoparticle Vaccine Based on Polyethyleneimine for Personalized Cancer Immunotherapy. Adv Sci (Weinh). 2021.
Moon JJ et al. Personalized combination nano-immunotherapy for robust induction and tumor infiltration of CD8+ T cells. Biomaterials. 2021.
Moon JJ et al. Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments. Front Pharmacol. 2021.
Moon JJ et al. Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates. J Control Release. 2021.
Moon JJ et al. Photothermal Therapy Combined with Neoantigen Cancer Vaccination for Effective Immunotherapy against Large Established Tumors and Distant Metastasis. Adv Ther (Weinh). 2021.
Moon JJ et al. Cancer nanomedicine for combination cancer immunotherapy. Nat Rev Mater. 2019.
Moon JJ et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Nör et al. Propolis reduces the stemness of head and neck squamous cell carcinoma. Arch Oral Biol. 2021.
Nor et al. Fabrication of Vascularized DPSC Constructs for Efficient Pulp Regeneration. J Dent Res. 2021.
Nor et al. A Member-Centric Association. J Dent Res. 2021.
Nör JE et al. mTOR Inhibition Ablates Cisplatin-Resistant Salivary Gland Cancer Stem Cells. J Dent Res. 2021.
Nör JE et al. VEGFR1 primes a unique cohort of dental pulp stem cells for vasculogenic differentiation. Eur Cell Mater. 2021.
Nör JE et al. Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells. Cell Death Dis. 2021.
Putnam AJ et al. Stromal Cell Identity Influences the In Vivo Functionality of Engineered Capillary Networks Formed by Co-Delivery of Endothelial Cells and Stromal Cells. Tissue Eng Part A. 2013.
Putnam AJ et al. Protease-Sensitive PEG Hydrogels Regulate Vascularization In Vitro and In Vivo. Macromol Biosci. 2014.
Putnam AJ et al. Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures. Sci Rep. 2018.
Putnam AJ et al. A Systems Mechanobiology Model to Predict Cardiac Reprogramming Outcomes on Different Biomaterials. Biomaterials. 2018.
Putnam AJ et al. Cell-mediated matrix stiffening accompanies capillary morphogenesis in ultrasoft amorphous hydrogels. Biomaterials. 2020.
Putnam AJ et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
Rao RC et al. Efficient serum-free derivation of oligodendrocyte precursors from neural stem cell-enriched cultures. Stem Cells. 2009.
Rao RC et al. Dynamic patterns of histone lysine methylation in the developing retina. Invest Ophthalmol Vis Sci. 2010.
Rao RC et al. Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1. Sci Rep. 2016.
Rao RC et al. Stem Cells for Retinal Disease: A Perspective on the Promise and Perils. Am J Ophthalmol. 2017.
Rao RC et al. p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Cell Rep. 2020.
Rao RC et al. The endangered physician-scientist and COVID-19. Cell Rep Med. 2021.
Rui et al. Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020.
Rui L et al. Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun. 2018.
Rui L et al. Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice. J Clin Invest. 2019.
Rui L et al. Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice. Proc Natl Acad Sci U S A. 2019.
Rui L et al. Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. Nat Commun. 2020.
Rui L et al. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. J Clin Invest. 2020.
Shea et al. Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering. Lancet Diabetes Endocrinol. 2021.
Shea et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea et al. Tolerance induced by antigen-loaded plg nanoparticles affects the phenotype and trafficking of transgenic cd4+ and cd8+ t cells. Cells. 2021.
Shea et al. Mechanistic contributions of Kupffer cells and liver sinusoidal endothelial cells in nanoparticle-induced antigen-specific immune tolerance. Biomaterials. 2022.
Shea et al. Neutrophil and natural killer cell imbalances prevent muscle stem cell-mediated regeneration following murine volumetric muscle loss. Proc Natl Acad Sci U S A. 2022.
Shea LD et al. Microporous scaffolds support assembly and differentiation of pancreatic progenitors into ß-cell clusters. Acta Biomater. 2019.
Shea LD et al. Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2019.
Shea LD et al. Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes. Cancer Res. 2020.
Shea LD et al. Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. Tissue Eng Part A. 2020.
Shea LD et al. Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis. Nat Commun. 2020.
Shea LD et al. An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides. J Control Release. 2021.
Shea LD et al. Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials. 2021.
Shea LD et al. Cargo-free immunomodulatory nanoparticles combined with anti-PD-1 antibody for treating metastatic breast cancer. Biomaterials. 2021.
Shea LD et al. IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury. Biotechnol Bioeng. 2021.
Soleimanpour SA et al. The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?. Trends Endocrinol Metab. 2013.
Soleimanpour SA et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014.
Soleimanpour SA et al. Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in beta cells. Diabetes. 2015.
Soleimanpour SA et al. Clec16a, Nrdp1, and USP8 form a ubiquitin-dependent tripartite complex that regulates beta cell mitophagy. Diabetes. 2018.
Soleimanpour SA et al. The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic beta cells and adipocytes. J Biol Chem. 2019.
Soleimanpour SA et al. Cell Cycle Regulation of the Pdx1 Transcription Factor in Developing Pancreas and Insulin-Producing β-Cells. Diabetes. 2021.
Soleimanpour SA et al. New aspects of diabetes research and therapeutic development. Pharmacol Rev. 2021.