Dental/Oral/Craniofacial
Reconstruction of dental, oral, and craniofacial tissues through tissue engineering and/or regenerative medicine is a major goal in dentistry. Research in this area includes the study of craniofacial/skeletal biology and disease including cancer and guided regenerative interventions for tissues lost due to disease or trauma.
Researchers
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Benjamin AllenMedicine -
Brendon BakerMedicine -
Marco BottinoDentistry -
Steven BuchmanMedicine -
Sally CamperMedicine -
Mark CohenMedicine -
Catherine CollinsLSA -
Cunming DuanLSA -
Sean EdwardsDentistry
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Mario FabiilliMedicine -
Stephen FeinbergDentistry -
Renny FranceschiDentistry -
Glenn GreenMedicine -
Kurt HankensonMedicine -
Nan HatchDentistry -
Darnell KaiglerDentistry
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David KohnDentistry -
Grant KrugerEngineering
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Joerg LahannEngineering -
Laurie McCauleyDentistry -
Yuji MishinaDentistry -
Mary-Ann MycekEngineering
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Jacques NörDentistry -
Noriaki OnoDentistry -
Andy PutnamEngineering -
Rajesh RaoMedicine -
Jan StegemannEngineering -
Homlay WangDentistry -
Jeff (Chin- Wei) WangDentistry -
Megan WeivodaDentistry -
David ZopfMedicine
Select Publications
Allen BL et al. Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 2014.
Allen BL et al. Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Biol Chem. 2015.
Allen BL et al. Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif. J Biol Chem. 2017.
Allen BL et al. Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib. Proc Natl Acad Sci U S A. 2017.
Allen BL et al. The Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development. Development. 2020.
Baker BM et al. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017.
Baker BM et al. Cell force-mediated matrix reorganization underlies multicellular network assembly. Sci Rep. 2019.
Baker BM et al. Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration. Nat Commun. 2019.
Baker BM et al. Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Lab Chip. 2020.
Baker BM et al. Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis. Sci Adv. 2020.
Bottino MC et al. A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics. J Biomed Mater Res B Appl Biomater. 2019.
Bottino MC et al. Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue. ACS Appl Mater Interfaces. 2020.
Bottino MC et al. Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration. Acta Biomater. 2020.
Bottino MC et al. Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection Ablation. Biomacromolecules. 2020.
Buchman SR et al. Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis. Ann Plast Surg. 2018.
Buchman SR et al. Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model. Ann Plast Surg. 2018.
Buchman SR et al. Nonvascularized Bone Graft Reconstruction of the Irradiated Murine Mandible: An Analogue of Clinical Head and Neck Cancer Treatment. J Craniofac Surg. 2019.
Buchman SR et al. The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. Plast Reconstr Sur. 2019.
Buchman SR et al. Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization. NPJ Regen Med. 2019.
Camper SA et al. Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era. Endocr Rev. 2016.
Camper SA et al. Next generation sequencing panel based on single molecule molecular inversion probes for detecting genetic variants in children with hypopituitarism. Mol Genet Genomic Med. 2018.
Camper SA et al. PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression. Endocrinology. 2020.
Camper SA et al. Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease. Hum Mol Genet. 2020.
Camper SA et al. Rathke’s cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors. J Clin Invest. 2020.
Collins CA et al. Mitochondrial fission, integrity and clearance require separable functions of Vps13D in Drosophila neurons. bioRxiv. 2020.
Collins CA et al. Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J Cell Biol. 2010.
Collins CA et al. The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol. 2012.
Collins CA et al. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. eLife. 2016.
Collins CA et al. Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104. Elife. 2017.
Duan C et al. Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc Natl Acad Sci U S A. 2010.
Duan C et al. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep. 2014.
Duan C et al. Ca2+ concentration-dependent premature death of igfbp5a mutant zebrafish reveals a critical role of IGF signaling in adaptive epithelial growth. Sci Signal. 2018.
Duan C et al. Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. Elife. 2019.
Duan C et al. The metalloproteinase Papp-aa controls epithelial cell quiescence to proliferation transition. Elife. 2020.
Fabiilli ML et al. Spatiotemporally-controlled transgene expression in hydroxyapatite-fibrin composite scaffolds using high intensity focused ultrasound. Biomaterials. 2019.
Fabiilli ML et al. Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation. Acta Biomater. 2019.
Fabiilli ML et al. Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds. Ultrason Sonochem. 2020.
Fabiilli ML et al. Spatially-directed cell migration in acoustically-responsive scaffolds via the controlled delivery of basic fibroblast growth factor. Acta Biomater. 2020.
Fabiilli ML et al. Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization. Soft Matter. 2020.
Feinberg SE et al. Tissue engineering of lips and muco-cutaneous junctions: in vitro development of tissue engineered constructs of oral mucosa and skin for lip reconstruction. Tissue Eng Part C Methods. 2012.
Feinberg SE et al. Intraoral grafting of tissue-engineered human oral mucosa. Int J Oral Maxillofac Implants. 2013.
Feinberg SE et al. Fabrication of Large Size Ex Vivo-Produced Oral Mucosal Equivalents for Clinical Application. Tissue Eng Part C Methods. 2015.
Feinberg SE et al. In Vitro Development of a Mucocutaneous Junction for Lip Reconstruction. J Oral Maxillofac Surg. 2016.
Feinberg SE et al. Soft Tissue Engineering. Oral Maxillofac Surg Clin North Am. 2017.
Franceschi RT et al. Discoidin Domain Receptor 2 Controls Bone Formation and Marrow Adipogenesis. J Bone Miner Res. 2016.
Franceschi RT et al. Control of the osteoblast lineage by mitogen-activated protein kinase signaling. Curr Mol Biol Rep. 2017.
Franceschi RT et al. Selective Role of Discoidin Domain Receptor 2 in Murine Temporomandibular Joint Development and Aging. J Dent Res. 2018.
Franceschi RT et al. Genetic inhibition of PPAR-gamma S112 phosphorylation reduces bone formation and stimulates marrow adipogenesis. Bone. 2018.
Green GE et al. Bioresorbable Airway Splint Created with a Three-Dimensional Printer. N Engl J Med. 2013.
Green GE et al. Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients. Sci Transl Med. 2015.
Green GE et al. Regulatory Considerations in the Design and Manufacturing of Implantable 3D-Printed Medical Devices. Clin Transl Sci. 2015.
Green GE et al. Co-culture of adipose-derived stem cells and chondrocytes on three-dimensionally printed bioscaffolds for craniofacial cartilage engineering. Laryngoscope. 2018.
Hankenson KD et al. Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regen Med. 2017.
Hankenson KD et al. R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Bone Res. 2018.
Hankenson KD et al. Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density. Nat Commun. 2019.
Hankenson KD et al. CTRP3 Regulates Endochondral Ossification and Bone Remodeling During Fracture Healing. J Orthop Res. 2020.
Hankenson KD et al. Canonical Notch signaling is required for bone morphogenetic protein-mediated human osteoblast differentiation. Stem Cells. 2020.
Hatch NE et al. Tissue-nonspecific Alkaline Phosphatase Deficiency Causes Abnormal Craniofacial Bone Development in the Alpl-/- Mouse Model of Infantile Hypophosphatasia. Bone. 2014.
Hatch NE et al. Microsphere controlled drug delivery for local control of tooth movement. Eur J Orthod. 2019.
Hatch NE et al. Tissue nonspecific alkaline phosphatase promotes calvarial progenitor cell cycle progression and cytokinesis via Erk1,2. Bone. 2019.
Hatch NE et al. Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2C342Y/+ mouse models of Crouzon syndrome. PLoS One. 2020.
Hatch NE et al. Genetic background dependent modifiers of craniosynostosis severity. J Struct Biol. 2020.
Kohn DH et al. Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A. 2009.
Kohn DH et al. Gene delivery via DNA incorporation within a biomimetic apatite coating. Biomaterials. 2009.
Kohn DH et al. PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol. 2016.
Kohn DH et al. Dual-functioning peptides discovered by phage display increase the magnitude and specificity of BMSC attachment to mineralized biomaterials. Biomaterials. 2017.
Kohn DH et al. Cell and material-specific phage display peptides increase iPS-MSC mediated bone and vasculature formation in vivo. Adv Healthc Mater. 2019.
Lahann et al. Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy. Nat Commun. 2020.
Lahann J et al. Cooperative Switching in Large‐Area Assemblies of Magnetic Janus Particles. Adv Funct Mater. 2020.
Lahann J et al. 3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures. Adv Mater. 2018.
Lahann J et al. Templated nanofiber synthesis via chemical vapor polymerization into liquid crystalline films. Science. 2018.
Lahann J et al. Engineered Fibrillar Fibronectin Networks as Three Dimensional Tissue Scaffolds. Adv Mater. 2019.
Lahann J et al. Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting. Macromol Rapid Commun. 2020.
McCauley LK et al. Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold. Biomaterials. 2017.
McCauley LK et al. Macrophages and skeletal health. Pharmacol Ther. 2017.
McCauley LK et al. Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone. J Clin Invest. 2018.
McCauley LK et al. Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide. FASEB J. 2018.
McCauley LK et al. Clodronate-loaded liposome treatment has site-specific skeletal effects. J Dent Res. 2019.
McCauley LK et al. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat Commun. 2020.
Mishina Y et al. BMP type I receptor inhibition prevents ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva. Nat Med. 2008.
Mishina Y et al. Augmented BMP signaling in neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. Development. 2015.
Mishina Y et al. Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation. Stem Cells. 2019.
Mishina Y et al. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway. J Biol Chem. 2019.
Mishina Y et al. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat Commun. 2020.
Mishina Y et al. Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes depending on anatomical positions of the bones in mice. Bone. 2020.
Mycek et al.Needle-compatible miniaturized optoelectronic sensor for pancreatic cancer detection. Sci Adv. 2020
Nör JE et al. Wnt/ß-catenin signaling determines the vasculogenic fate of post-natal mesenchymal stem cells. Stem Cells. 2016.
Nör JE et al. Animal models for stem cell-mediated de novo dental pulp regeneration: Foundation for human clinical applications. Tissue Eng Part B Rev. 2019.
Nör JE et al. VE-cadherin is required for differentiation and anastomosis of blood vessels formed by mesenchymal stem cells. J Dent Res. 2020.
Nör JE et al. Endothelial-initiated crosstalk regulate dental pulp stem cell self-renewal. J Dent Res. 2020.
Nör JE et al. SCF/c-Kit signaling regulates self-renewal of dental pulp stem cells. J Endod. 2020.
Ono N et al. Diverse contribution of Col2a1-expressing cells to the craniofacial skeletal cell lineages. Orthod Craniofac Res. 2017.
Ono N et al. Msx2 Marks Spatially Restricted Populations of Mesenchymal Precursors. J Dent Res. 2018.
Ono N et al. Resting zone of the growth plate houses a unique class of skeletal stem cells. Nature. 2018.
Ono N et al. Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells. J Bone Miner Res. 2019.
Ono N et al. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nat Commun. 2020.
Ono N et al. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nat Commun. 2020.
Putnam AJ et al. Stromal Cell Identity Influences the In Vivo Functionality of Engineered Capillary Networks Formed by Co-Delivery of Endothelial Cells and Stromal Cells. Tissue Eng Part A. 2013.
Putnam AJ et al. Protease-Sensitive PEG Hydrogels Regulate Vascularization In Vitro and In Vivo. Macromol Biosci. 2014.
Putnam AJ et al. Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures. Sci Rep. 2018.
Putnam AJ et al. A Systems Mechanobiology Model to Predict Cardiac Reprogramming Outcomes on Different Biomaterials. Biomaterials. 2018.
Putnam AJ et al. Cell-mediated matrix stiffening accompanies capillary morphogenesis in ultrasoft amorphous hydrogels. Biomaterials. 2020.
Putnam AJ et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
Rao RC et al. Efficient serum-free derivation of oligodendrocyte precursors from neural stem cell-enriched cultures. Stem Cells. 2009.
Rao RC et al. Dynamic patterns of histone lysine methylation in the developing retina. Invest Ophthalmol Vis Sci. 2010.
Rao RC et al. Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1. Sci Rep. 2016.
Rao RC et al. Stem Cells for Retinal Disease: A Perspective on the Promise and Perils. Am J Ophthalmol. 2017.
Rao RC et al. p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Cell Rep. 2020.
Stegemann JP et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
Wang CW Personalized Precision Integration of Augmentation and Implant Surgeries with Accelerated Adult Orthodontics for Synergized Interdisciplinary Care. Effective, Efficient and Personalized Orthodontics: Patient-centered Approaches and Innovations. Craniofacial Growth Series, Center for Human Growth and Development (Kim-Berman H, Franchi L, Ruellas A, eds). 2020.
Wang CW et al. Maresin 1 Accelerates Tooth Extraction Wound Healing and Bone Regeneration for Alveolar Ridge Preservation. J Dent Res. 2020.
Wang CW et al. Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis- A Randomized Controlled Clinical Trial. J Periodontol. 2020.
Wang H-L et al. Periodontal regeneration. J Periodontol. 2005.
Wang H-L et al. A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement surgery: I. Clinical and radiographic parameters. Clin Oral Implants Res. 2014.
Wang H-L et al. Protein and microbial biomarkers in peri-Implantitis. Clin Oral Implants Res. 2016.
Wang H-L et al. Comparison of Three Different Types of Fixed Partial Implant Prosthesis: A Long-Term Retrospective Study of Clinical Outcomes and Cost Effectiveness. Clin Oral Implants Res, 2019;30(4):295-305. Clin Oral Implants Res. 2019.
Wang H-L et al. Using Periodontal Staging and Grading System as a Prognostic Factor for Future Tooth Loss: A Long-Term Retrospective Study. J Periodontol. 2020.
Weivoda et al. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. Nat Commun. 2020.
Weivoda MM et al. Osteoclast TGF-ß receptor signaling induces Wnt1 secretion and couples bone resorption to bone formation. J Bone Miner Res. 2016.
Weivoda MM et al. Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife. 2015.
Weivoda MM et al. Targeting cellular senescence prevents age-related bone loss in mice. Nat Med. 2017.
Weivoda MM et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018.
Weivoda MM et al. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. Nat Commun. 2020.
Zopf DA et al. Bioresorbable airway splint created with a three-dimensional printer. N Engl J Med. 2013.
Zopf DA et al. Computer aided-designed, 3-dimensionally printed porous tissue bioscaffolds for craniofacial soft tissue reconstruction. Otolaryngol Head Neck Surg. 2014.
Zopf DA et al. A multidisciplinary international collaborative implementing low cost, high fidelity 3D printed airway models to enhance Ethiopian anesthesia resident emergency cricothyroidotomy skills. Int J Pediatr Otorhinolaryngol. 2018.
Zopf DA et al. Anatomic-Based Design, Manufacturing, and Preclinical Assessment of a Novel 3D-Printed Bioscaffold for Total Nasal Reconstruction. Facial Plast Surg Aesthet Med. 2020.
Zopf DA et al. Hybrid Three-Dimensional-Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications. Laryngoscope. 2020.