Cardiovascular
Cardiovascular disease is a class of diseases that involve the heart or blood vessels, and includes coronary artery diseases such as angina, myocardial infarction (commonly known as a heart attack), stroke, cardiomyopathy, heart arrhythmia, congenital heart disease, and many others, and the underlying mechanisms vary depending on the disease in question.
Researchers
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Brendon BakerMedicine -
Eugene ChenMedicine -
Mario FabiilliMedicine -
Jianping FuEngineering -
Idse HeemskerkMedicine -
Todd HerronMedicine -
Lori IsomMedicine -
David KohnDentistry -
Grant KrugerEngineering -
Joerg LahannEngineering -
Liu LiuMedicine
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Jacques NörDentistry -
Andy PutnamEngineering -
Brian RossMedicine
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Peter ScottMedicine
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Max ShteinEngineering -
Ming-Sing SiMedicine
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Gary D. SmithMedicine -
Jan StegemannEngineering -
Zhong WangMedicine -
Bo YangMedicine
Select Publications
Baker BM et al. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017.
Baker BM et al. Cell force-mediated matrix reorganization underlies multicellular network assembly. Sci Rep. 2019.
Baker BM et al. Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration. Nat Commun. 2019.
Baker BM et al. Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Lab Chip. 2020.
Baker BM et al. Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis. Sci Adv. 2020.
Baker BM et al. Microenvironmental determinants of organized iPSC-cardiomyocyte tissues on synthetic fibrous matrices. Biomater Sci. 2021.
Baker BM et al. Stable and transient bubble formation in acoustically-responsive scaffolds by acoustic droplet vaporization: theory and application in sequential release. Ultrason Sonochem. 2021.
Baker BM et al. Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform. Lab Chip. 2021.
Baker BM et al. New directions and dimensions for bioengineered models of fibrosis. Nat Review Mater. 2021.
Chen et al. MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Nat Commun. 2020.
Chen et al. Genetically Modified Rabbits for Cardiovascular Research. Front Genet. 2021.
Chen YE et al. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration. Biomaterials. 2015.
Chen YE et al. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun. 2016.
Chen YE et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016.
Chen YE et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors. Arterioscler Thromb Vasc Biol. 2018.
Chen YE et al. Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis. Antioxid Redox Signal. 2021.
Chen YE et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Chen YE et al. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021.
Chen YE et al. Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis. 2021.
Chen YE et al. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine. 2021.
Chen YE et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Chen YE et al. Translating Cardiovascular Genomics to Clinical Practice. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases. Cardiovasc Drugs Ther. 2021.
Chen YE et al. Biomimetic tubular scaffold with heparin conjugation for rapid degradation in in situ regeneration of a small diameter neoartery. Biomaterials. 2021.
Chen YE et al. Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport. J Control Rel. 2021.
Cohen et al. Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics. Ann Surg. 2021.
Dressler et al. Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021.
Duncan RK et al. Matrigel is required for efficient differentiation of isolated, stem cell-derived otic vesicles into inner ear organoids. Stem Cell Res. 2021.
Edwards et al. Dental students’ OMFS-related experiences and interest in OMFS careers: An exploration. J Dent Educ. 2021.
Edwards et al. Squamous Cell Carcinoma of the Tongue in Young Patients: A Case Series and Literature Review. J Oral Maxillofac Surg. 2021.
Fabiilli ML et al. Spatiotemporally-controlled transgene expression in hydroxyapatite-fibrin composite scaffolds using high intensity focused ultrasound. Biomaterials. 2019.
Fabiilli ML et al. Controlled delivery of basic fibroblast growth factor (bFGF) using acoustic droplet vaporization stimulates endothelial network formation. Acta Biomater. 2019.
Fabiilli ML et al. Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds. Ultrason Sonochem. 2020.
Fabiilli ML et al. Spatially-directed cell migration in acoustically-responsive scaffolds via the controlled delivery of basic fibroblast growth factor. Acta Biomater. 2020.
Fabiilli ML et al. Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization. Soft Matter. 2020.
Feldman EL et al. Diabetic neuropathy in children and youth: New and emerging risk factors. Pediatr Diabetes. 2021.
Feldman EL et al. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron. 2021.
Feldman EL et al. Amyotrophic Lateral Sclerosis Survival Associates With Neutrophils in a Sex-specific Manner. Neurol Neuroimmunol Neuroinflamm. 2021.
Feldman EL et al. Immune-mediated vincristine-induced neuropathy: Unlocking therapies. J Exp Med. 2021.
Feldman EL et al. Lessons for clinical trial design in Friedreich’s ataxia. Lancet Neurol. 2021.
Feldman EL et al. High dietary fat consumption impairs axonal mitochondrial function in Vivo. J Neurosci. 2021.
Feldman EL et al. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. Faseb J. 2021.
Feldman EL et al. Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes. Ann Clin Transl Neurol. 2021.
Feldman EL et al. NK cells associate with ALS in a sex- and age-dependent manner. JCI Insight 2021.
Feldman EL et al. The determinants of complication trajectories in American Indians with type 2 diabetes. JCI Insight. 2021.
Feldman et al. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021.
Fu J et al. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2017.
Fu J et al. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017.
Fu J et al. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nat Mater. 2018.
Fu J et al. Controlled modeling of human epiblast and amnion development using stem cells. Nature. 2019.
Fu J et al. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Sci Adv. 2019.
Fu J et al. Visualization and quantification of dynamic intercellular coupling in human embryonic stem cells using single cell sonoporation. Sci Rep. 2020.
Fu J et al. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021.
Hammer GD et al. What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics. Endocr Pathol. 2021.
Heemskerk I Full of potential: Pluripotent stem cells for the systems biology of embryonic patterning. Dev Biol. 2020.
Heemskerk I et al. Tissue cartography: compressing bio-image data by dimensional reduction. Nat Methods. 2015.
Heemskerk I et al. Differential growth triggers mechanical feedback that elevates Hippo signaling. Proc Natl Acad Sci U S A. 2016.
Heemskerk I et al. Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells. Elife. 2019.
Heemskerk I et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Phys Biol. 2021.
Herron et al. Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes. Sci Rep. 2020.
Herron et al. In vitro model of ischemic heart failure using human induced pluripotent stem cell–derived cardiomyocytes. JCI Insight. 2021.
Herron et al.Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations. Regul Toxicol Pharmacol. 2020
Herron TJ Stiffness triggers non-coding RNA pathology. Nat Biomed Eng. 2019.
Herron TJ et al. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes. J Mol Cell Cardiol. 2016.
Herron TJ et al. hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen. Sci Rep. 2017.
Herron TJ et al. Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors. Nat Commun. 2019.
Herron TJ et al. Detection of Drug-Induced Torsades de Pointes Arrhythmia Mechanisms Using hiPSC-CM Syncytial Monolayers in a High-Throughput Screening Voltage Sensitive Dye Assay. Toxicol Sci. 2020.
Isom LL et al. SCN1B-linked early infantile developmental and epileptic encephalopathy. Ann Clin Transl Neurol. 2019.
Isom LL et al. Voltage-gated sodium channel ß1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. J Biol Chem. 2020.
Isom LL et al. Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Sci Transl Med. 2020.
Isom LL et al. Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons. Brain. 2020.
Isom LL et al. Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Ann Clin Transl Neurol. 2020.
Kohn DH et al. Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proc Natl Acad Sci U S A. 2009.
Kohn DH et al. Gene delivery via DNA incorporation within a biomimetic apatite coating. Biomaterials. 2009.
Kohn DH et al. PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol. 2016.
Kohn DH et al. Dual-functioning peptides discovered by phage display increase the magnitude and specificity of BMSC attachment to mineralized biomaterials. Biomaterials. 2017.
Kohn DH et al. Cell and material-specific phage display peptides increase iPS-MSC mediated bone and vasculature formation in vivo. Adv Healthc Mater. 2019.
Kozloff KM et al. In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging. Bone. 2021.
Kozloff KM et al. Altered collagen chemical compositional structure in osteopenic women with past fractures: A case-control Raman spectroscopic study. Bone. 2021.
Lahann et al. Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy. Nat Commun. 2020.
Lahann J et al. Nanoparticle Tracking Analysis of Polymer Nanoparticles in Blood Plasma. Part Part Syst Charact. 2021.
Lahann J et al. Cooperative Switching in Large‐Area Assemblies of Magnetic Janus Particles. Adv Funct Mater. 2020.
Lahann J et al. 3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures. Adv Mater. 2018.
Lahann J et al. Templated nanofiber synthesis via chemical vapor polymerization into liquid crystalline films. Science. 2018.
Lahann J et al. Engineered Fibrillar Fibronectin Networks as Three Dimensional Tissue Scaffolds. Adv Mater. 2019.
Lahann J et al. Multifunctional Synthetic Protein Nanoparticles via Reactive Electrojetting. Macromol Rapid Commun. 2020.
Lahann J et al. Stepwise cell seeding on tessellated scaffolds to study sprouting blood vessels. J Vis Exp. 2021.
Lahann J et al. Performance Fabrics Obtained by In Situ Growth of Metal-Organic Frameworks in Electrospun Fibers. ACS Appl Mater Interfaces. 2021.
Lahann J et al. 3D jet writing of mechanically actuated tandem scaffolds. Sci Adv. 2021.
Lahann J et al. Targeting gliomas with STAT3-silencing nanoparticles. Mol Cell Onc. 2021.
Lee et al. Reduced Mammography Screening for Breast Cancer among Women with Visual Impairment. Opthalmology. 2021.
Liu AP et al. Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung. Stem Cells Transl Med. 2021.
Liu L et al. MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells. Stem Cells. 2012.
Liu L et al. Mesenchymal stem cells ameliorate Th1-induced pre-eclampsia-like symptoms in mice via the suppression of TNF-α expression. PLoS One. 2014.
Liu L et al. Improving cardiac reprogramming for heart regeneration. Curr Opin Organ Transplant. 2016.
Liu L et al. Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts. Cell Discov. 2016.
Liu L et al. Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. J Biol Chem. 2019.
Love et al. A meta-analysis of bone cement mediated antibiotic release: Overkill, but a viable approach to eradicate osteomyelitis and other infections tied to open procedures. Mater Sci Eng C Mater Biol Appl. 2021.
Nör JE et al. Wnt/ß-catenin signaling determines the vasculogenic fate of post-natal mesenchymal stem cells. Stem Cells. 2016.
Nör JE et al. Animal models for stem cell-mediated de novo dental pulp regeneration: Foundation for human clinical applications. Tissue Eng Part B Rev. 2019.
Nör JE et al. VE-cadherin is required for differentiation and anastomosis of blood vessels formed by mesenchymal stem cells. J Dent Res. 2020.
Nör JE et al. Endothelial-initiated crosstalk regulate dental pulp stem cell self-renewal. J Dent Res. 2020.
Nör JE et al. SCF/c-Kit signaling regulates self-renewal of dental pulp stem cells. J Endod. 2020.
Nör JE et al. Survival of salivary gland cancer stem cells requires mTOR signaling. Cell Death Dis. 2021.
Ono N et al. Intercellular Interactions of an Adipogenic CXCL12-Expressing Stromal Cell Subset in Murine Bone Marrow. J Bone Miner Res. 2021.
Putnam AJ et al. Stromal Cell Identity Influences the In Vivo Functionality of Engineered Capillary Networks Formed by Co-Delivery of Endothelial Cells and Stromal Cells. Tissue Eng Part A. 2013.
Putnam AJ et al. Protease-Sensitive PEG Hydrogels Regulate Vascularization In Vitro and In Vivo. Macromol Biosci. 2014.
Putnam AJ et al. Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures. Sci Rep. 2018.
Putnam AJ et al. A Systems Mechanobiology Model to Predict Cardiac Reprogramming Outcomes on Different Biomaterials. Biomaterials. 2018.
Putnam AJ et al. Cell-mediated matrix stiffening accompanies capillary morphogenesis in ultrasoft amorphous hydrogels. Biomaterials. 2020.
Putnam AJ et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
Rajapakse I et al. TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization. Neoplasia. 2021.
Rajapakse I et al. Network dynamics of hypothalamic feeding neurons. Proc Natl Acad Sci U S A. 2021.
Ross et al. Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution. Nat Commun. 2020.
Scott et al. In vitro binding affinity vs. in vivo site occupancy: A PET study of four diastereomers of dihydrotetrabenazine (DTBZ) in monkey brain. Nucl Med Biol. 2021.
Shtein M et al. Developable Rotationally Symmetric Kirigami-Based Structures as Sensor Platforms. Adv Mater. 2019.
Shtein M et al. Dynamic kirigami structures for integrated solar tracking. Nat Comm. 2017.
Shtein M et al. Printing of small molecular medicines from the vapor phase. Nat Comm. 2017.
Shtein M et al. An electric-eel-inspired soft power source from stacked hydrogels. Nature. 2017.
Shtein M et al. Chemical Vapor Jet Deposition of Parylene Polymer Films in Air. Macromolecules. 2015.
Si et al. Commentary: Aortic aneurysms are not created equal. J Thorac Cardiovasc Surg. 2020.
Si et al. Cost-effectiveness of implantable ventricular assist devices in older children with stable, inotrope-dependent dilated cardiomyopathy. Pediatr Transplant. 2021.
Smith et al. Lipidomic markers of sperm cryotolerance in cattle. Sci Rep. 2020.
Smith GD et al. Deficient cMyBP-C protein expression during cardiomyocyte differentiation underlies human hypertrophic cardiomyopathy cellular phenotypes in disease specific human ES cell derived cardiomyocytes. J Mol Cell Cardiol. 2016.
Smith GD et al. Targeted reactivation of FMR1 transcription in fragile X syndrome embryonic stem cells. Front Mol Neurosci. 2018.
Smith GD et al. Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line. Stem Cell Res. 2019.
Smith GD et al. Histone acetyltransferase MOF regulates fatty acid oxidation and cellular metabolism in cell fate determination. Cell Stem Cell. 2020.
Smith GD et al. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020.
Stegemann JP et al. Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo. Sci Rep. 2020.
Wang CW Is periodontal phenotypic conversion therapy beneficial for patients receiving orthodontic treatment? An American Academy of Periodontology Best Evidence Review. J Periodontol. 2020.
Wang Z et al. HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction. EBioMedicine. 2019.
Wang Z et al. Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. J Biol Chem. 2019.
Wang Z et al. SWI/SNF component BAF250a coordinates OCT4 and WNT signaling pathway to control cardiac lineage differentiation. Front Cell Dev Biol. 2020.
Wang Z et al. Biodegradable nanofibrous temperature-responsive gelling microspheres for heart regeneration. Adv Funct Mater. 2020.
Wang Z et al. Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via mediating histone acetylation. bioRxiv. 2019.
Yang B et al. Engineering vascular tissue with functional smooth muscle cells derived from human iPS cells and nanofibrous scaffolds. Biomaterials. 2014.
Yang B et al. Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves. EBioMedicine. 2016.
Yang B et al. Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage. Stem Cells. 2017.
Yang B et al. Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve. Nat Commun. 2017.
Yang B et al. In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2020.
Yang B et al. Thoracic Endovascular Aortic Repair in the Setting of Compromised Distal Landing Zones. Ann Thorac Surg. 2021.
Yang B et al. Reply from the author: respect mother nature-aortic root repair in acute type A aortic dissection. J Thorac Cardiovasc Surg. 2021.
Yang B et al. Reply from authors: Thoracic endocascular aortic repair versus fenestration/stenting: both effective weapons for the same disease. J Thorac Cardiovasc Surg. 2021.
Yang B et al. Reply: Thoracic Endovascular Aortic Repair versus Fenestration/Stenting: both effective weapons for the same disease. J Thorac Cardiovasc Surg. 2021.
Yang B. et al. Impact of Chronic Renal Failure on Surgical Outcomes in Patients With Infective Endocarditis. Ann Thorac Surg. 2021.
Yang B. et al. Is hemiarch replacement adequate in acute type A aortic dissection repair in patients with arch branch vessel dissection without cerebral malperfusion?. J Thorac Cardiovasc Surg. 2021.
Yang B. et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021.
Yang et al. Higher admission rates and in-hospital mortality for acute type A aortic dissection during Influenza season: a single center experience. Sci Rep. 2020.